Synthesis of cortistatins A, J, K and L was written by Flyer, Alec N.;Si, Chong;Myers, Andrew G.. And the article was included in Nature Chemistry in 2010.Product Details of 75476-83-4 The following contents are mentioned in the article:
The cortistatins are a recently identified class of marine natural products characterized by an unusual steroidal skeleton, which have been found to inhibit differentially the proliferation of various mammalian cells in culture by an unknown mechanism. We describe a comprehensive route for the synthesis of cortistatins from a common precursor, azide I, which in turn is assembled from two fragments of similar structural complexity. Cortistatins A and J, and for the first time K and L, have been synthesized in parallel processes from like intermediates prepared from a single compound With the identification of facile laboratory transformations linking intermediates in the cortistatin L synthetic series with corresponding intermediates to cortistatins A and J, we have been led to speculate that somewhat related paths might occur in nature, offering potential sequencing and chem. detail for cortistatin biosynthetic pathways. The antiproliferative activity of the cortistatins was tested against HUVECs. This study involved multiple reactions and reactants, such as 7-Iodoisoquinoline (cas: 75476-83-4Product Details of 75476-83-4).
7-Iodoisoquinoline (cas: 75476-83-4) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Product Details of 75476-83-4
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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem