Category: 86-51-1

Maddila, Surya N. published the artcileFacile One-pot Synthesis of Arylsulfonyl-4H-pyrans Catalyzed by Ru Loaded Fluorapatite, SDS of cas: 86-51-1, the main research area is arylsulfonyl pyran preparation green chem; aldehyde dimedone phenylsulfonyl acetonitrile three component reaction.

A novel ecofriendly cascade reaction for the synthesis of arylsulfonyl-4H-pyran derivatives by a three component fusion reaction of chosen aldehyde, dimedone and phenylsulfonyl acetonitrile at room temperature using ruthenia doped fluorapatite (RuO2/FAp) as recyclable catalyst is reported. Different percentages of RuO2/FAp materials were prepared and characterized by FT-IR, P-XRD, BET, SEM-EDX and TEM anal. Attractive features of the synthetic approach are operational simplicity, cost-effectiveness, short reaction time and excellent yields. Easily recoverable and reusable catalyst material without any deceptive loss of catalytic activity up to seven cycles is addnl. benefit.

ChemistrySelect published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, SDS of cas: 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Devi, Lagudu published the artcileA rapid, sustainable and environmental friendly protocol for the catalyst-free synthesis of 2-methyl-5-oxo-hexahydroquinoline-3-carboxylate via ultrasonic irradiation, Application In Synthesis of 86-51-1, the main research area is methyl oxo hexahydroquinoline carboxylate green preparation ultrasonic irradiation; benzaldehyde cyclohexanedione benzyl acetoacetate multicomponent.

A facile, economic, highly valuable and sustainable protocol for the synthesis of substituted 2-methyl-5-oxo-hexahydroquinoline-3-carboxylate derivatives I [R = 2-FC6H4, 2-BrC6H4, 4-N(Me)2C6H4, etc.] was developed via one-pot, the multicomponent reaction of various benzaldehydes, 1,3-cyclohexanedione, benzyl acetoacetate and ammonium acetate in EtOH under ultrasound irradiation at room temperature condition. Employment of green solvent and catalyst-free conditions made this approach very fascinating from cost-effective and eco-friendly viewpoints. Mainly, this protocol offered various benefits such as easy handling, cleaner reaction, operational simplicity, simple work-up system, excellent yields (92-98%), rapid reaction time and condensed environmental consequences.

Chemical Data Collections published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application In Synthesis of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Devi, Lagudu published the artcileA green, efficient protocol for the catalyst-free synthesis of tetrahydro-1H-pyrazolo-[3,4-b]-quinolin-5(4H)-ones supported by ultrasonic irradiation, Name: 2,3-Dimethoxybenzaldehyde, the main research area is amino phenylpyrazole benzaldehyde dimedone three component reaction green chem; diphenyl tetrahydropyrazoloquinolinone preparation ultrasonication.

A green and efficient protocol for the one-pot, multicomponent, catalyst-free synthesis of tetrahydro-1H-pyrazolo[3,4-b]quinolin-5(4H)-ones I [R = 2-hydroxyphenyl, 4-ethylphenyl, 3-nitrophenyl, etc.] from the reaction of 5-amino-3-methyl-1-phenylpyrazole, benzaldehydes and dimedone in ethanol as green solvent under ultrasound irradiation was described. This protocol offered several benefits such as simple handling, easy workup process, waste-free, milder reaction conditions, cleaner reaction, environment-friendly, short reaction times, absence of any tedious purification and excellent yields.

Chemical Data Collections published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Name: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lichitsky, Boris V. published the artcileBenzimidazolyl-pyrazolo[3,4-b]pyridinones – selective inhibitors of MOLT-4 leukemia cell growth and sea urchin embryo spiculogenesis: Target quest., Safety of 2,3-Dimethoxybenzaldehyde, the main research area is benzimidazolylpyrazolopyridinone preparation SAR human; MOLT4 leukemia cell growth spiculogenesis inhibitor; MOLT-4; benzimidazolyl-pyrazolo[3,4-b]pyridinone; cytotoxicity; sea urchin embryo; spiculogenesis.

1,3-Substituted pyrazolo[3,4-b]pyridinones were synthesized by a three-component condensation of Meldrum’s acid with aryl aldehydes and 1,3-substituted 5-aminopyrazoles. Their biol. activity was evaluated using the in vivo phenotypic sea urchin embryo assay and the in vitro cytotoxicity screen against human cancer cell lines. In the sea urchin embryo model, 1-benzimidazolyl-pyrazolo[3,4-b]pyridinones caused inhibition of hatching and spiculogenesis at submicromolar concentrations These compounds also selectively and potently inhibited growth of the MOLT-4 leukemia cell line. Subsequent structure-activity relationship studies determined the benzimidazolyl fragment as an essential pharmacophore for both effects. A preliminary QSAR target identification search did not result in tangible leads. Attempts to prepare a relevant photoaffinity probe that retained potency in both assays were not successful. 1-Benzimidazolyl-pyrazolo[3,4-b]pyridinones were further characterized for their activity in a wild type vs Notch-mutant leukemia cell lines, and in in vitro panels of kinases and matrix metalloproteinases. Using a series of diverse modulators of spiculogenesis as standards, multiple signaling networks including Notch, Wnt/-catenin, receptor tyrosine kinases (VEGF/VEGFR, FGF/FGFR), PI3K, and Raf-MEK-ERK were excluded as possible targets of 1-benzimidazolyl-pyrazolo[3,4-b]pyridinones. On the other hand, matrix metalloproteinase-9/hatching enzyme was identified as one potential target.

ACS Combinatorial Science published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Safety of 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shirzaei, Farhad published the artcileOne-Pot Synthesis of New Chromeno[1,6]naphthyridine Derivatives Catalyzed by a Basic Ionic Liquid, [HO-CH2-CH2-NH3+][HCOO-], Quality Control of 86-51-1, the main research area is chromenonaphthyridine preparation green chem; benzaldehyde malononitrile hydroxyacetophenone multicomponent condensation ionic liquid catalyst.

The authors report a one-pot, efficient, pseudo-four-component condensation of aromatic aldehydes R1CHO [R1 = Ph, 4-FC6H4, 2,3,4-(MeO)3C6H2, etc.], malononitrile, 2′-hydroxyacetophenone derivatives 2-HO-4-R2C6H3C(O)CH3 (R2 = H, OH) in the presence of a reusable basic ionic liquid, [HO-CH2-CH2-NH3+][HCOO-], as catalyst for the synthesis of chromeno[1,6]naphthyridine derivatives I in water as a green solvent at reflux conditions. The method has several advantages such as good yields, short reaction times, and a simple work-up procedure.

ChemistrySelect published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Quality Control of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mohamadpour, Farzaneh published the artcileSynthesis of Pyran-Annulated Heterocyclic Systems Catalyzed by Theophylline as a Green and Bio-Based Catalyst, Safety of 2,3-Dimethoxybenzaldehyde, the main research area is tetrahydrobenzopyran preparation green chem; aryl aldehyde malononitrile dimedone tandem theophylline biocatalyst; pyranopyrimidinone preparation green chem; malononitrile aryl aldehyde barbituric acid tandem theophylline biocatalyst; dihydropyranopyrazole preparation green chem; ethyl acetoacetate aldehyde hydrazine hydrate malononitrile tandem theophylline biocatalyst.

A green synthetic route to the convenient preparation of tetrahydrobenzo[b]pyrans I [R1 = Ph, 4-O2NC6H4, 2,3-(H3CO)2C6H3, etc.], pyrano[2,3-d]pyrimidinones II (R2 = Ph, 2,4-Cl2C6H3, 2-O2NC6H4, etc.; R3 = H, Me) and dihydropyrano[2,3-c]pyrazoles III (R4 = Ph, 3-O2NC6H4, 2-OHC6H4, etc.) scaffolds have been developed using theophylline as a green and bio-based catalyst via tandem Knoevenagel-Michael cyclocondensation reaction in aqueous/ethanol media. All reactions are completed in short period of times and the products are obtained in excellent yields. The salient features of this environmentally friendly approach are green and bio-based catalyst, straightforward work-up with no column chromatog. separation, one-pot procedures, economical and clean synthesis, avoidance of toxic organic solvents and high atom-economy.

Polycyclic Aromatic Compounds published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Safety of 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Maddila, S. published the artcileV-CaHAp as a recyclable catalyst for the green multicomponent synthesis of benzochromenes, COA of Formula: C9H10O3, the main research area is benzochromene preparation green chem; naphthol benzaldehyde malononitrile multicomponent condensation vanadium calcium hydroxyapatite catalyst.

A simple and efficient one-pot method has been developed for the synthesis of benzochromenes I [R = 2-Cl, 4-CH3CH2, 2,5-(OCH3)2, etc.], using V-CaHAp as a heterogeneous catalyst by the condensation of aldehydes RC6H4CHO, β-naphthol and malononitrile in ethanol as solvent at room temperature for 20 min. The reaction, with this catalyst is carried out under mild reaction conditions with very good to excellent yields (89-98%). The material can be recycled very easily and reused for at least 6 runs without substantial loss in activity, which makes this methodol. environmentally benign. A feasible and cost-effective synthesis by using non-toxic materials and minimal catalyst, which is easy to handle has been achieved.

Arabian Journal of Chemistry published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Babaei, Pouria published the artcileL-proline covered N doped graphene quantum dots modified CuO/ZnO hexagonal nanocomposite as a robust retrievable catalyst in synthesis of substituted chiral 2-amino-4H-chromenes, COA of Formula: C9H10O3, the main research area is proline functinalized copper zinc oxide nanoparticle preparation surface structure; benzaldehyde dimedone malononitrile copper zinc oxide nanocatalyst three component; phenyl amino oxochromene carbonitrile preparation microwave irradation green chem; malononitrile benzaldehyde hydroxycoumarine copper zinc oxide nanocatalyst three component; amino phenyl oxopyranochromene carbonitrile preparation microwave irradation green chem.

L-proline assisted CuO/ZnO@N-GQDs hexagonal nanocomposites as a robust recyclable nanocatalyst in multicomponent reactions for the preparation of 2-amino-4H-chromenes. As-prepared CuO/ZnO@N-GQDs@L-proline nanocatalyst was investigated by High-resolution Transmission electron microscope , Transmission electron microscope, Field emission SEM, Brunauer-Emmett-Teller (BET), Energy-dispersive X-ray spectroscopy, Fourier transform IR spectroscopy, Thermogravimetric anal., and X-ray diffraction anal.. High atom economy (95%), recyclability catalyst (8 runs), avoided the utilization of further reagents such as additives, and excellent yield of products (80-94%) are a few vital highlights of this method.

Materials Chemistry and Physics published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shabalala, Nhlanhla Gracious published the artcileAn Efficient and Sustainable Protocol for the Synthesis of Poly-Functionalized-Pyran Derivatives under Ultrasound Irradiation, Safety of 2,3-Dimethoxybenzaldehyde, the main research area is benzaldehyde malononitrile dimedone three component one pot reaction ultrasonication; phenyl tetrahydrobenzopyran preparation green chem; barbituric acid benzaldehyde malononitrile three component one pot ultrasonication; tetrahydropyranopyrimidine phenyl preparation green chem.

A highly efficient and catalyst-free green synthetic protocol was developed for the synthesis of two series of poly-functionalized pyran derivatives I [R = 2-Cl, 3-OH-4-MeO, 2,4,6-tri-MeO, etc.] and II [R1 = 2-Cl, 2-NO2, 2-Cl-6-F, 2-CF3, 2-Br] via the one-pot reaction of benzaldehydes, malononitrile and either dimedone or 1,3-di-Me barbituric acid with EtOH: H2O (1:1 volume/volume) as solvent under ultrasound irradiation Excellent yields (90-99%) of desired pyran derivatives I and II were obtained for rapid reaction time 5 min. The structural features of the synthesized compounds I and II were fully characterized by spectroscopic techniques (IR, HRMS 1H and 13C NMR). A simple workup, clean reaction profile, short reaction times, excellent yields, 95% atom economy, and 100% carbon efficiency are the benefits of the proposed protocol. In addition, the circumvention of the chromatog. separations is the further advantage of the procedure.

Polycyclic Aromatic Compounds published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Safety of 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Oboudatian, Hourieh Sadat published the artcileSilica nanospheres KCC-1 as a good catalyst for the preparation of 2-amino-4H-chromenes by ultrasonic irradiation, Computed Properties of 86-51-1, the main research area is aldehyde condensation malononitrile naphthalenediol ultrasound fibrous nanosilica sphere catalyst; chromene bis amino nitrile preparation.

Fibrous nano-silica sphere (KCC-1) has appeared as a good and efficient catalyst for ultrasonic irradiation conditions in chem. reactions. This catalyst has the unique properties such as a fibrous surface morphol., high surface area and high mech. stability. Morphol., structure, and composition of the fibrous nano-silica sphere were described by N2 adsorption-desorption anal., SEM (SEM), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), thermogravimetric anal. (TGA) and Fourier-transform IR spectroscopy (FT-IR). In this work, KCC-1@NH2 nanosilica was used as a basic catalyst for the preparation of chromenes I [R = Ph, 3-HOC6H4, 2,3-(MeO)2C6H3, etc.] from 1,5-naphthalenediol, malononitrile and the corresponding aldehydes RCHO under ultrasonic irradiation conditions for the first time. The recyclability, nontoxicity and high stability of the catalyst, combined with low reaction times and excellent yields, make the present protocol very useful for the synthesis of the title products under ultrasonic conditions. The structures of the products were confirmed via 1H NMR, 13C NMR, and FT-IR anal.

Scientific Reports published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Computed Properties of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem