Category: isoquinoline

Maddila, Suresh published the artcileUltrasound mediated green synthesis of pyrano[2,3-c]pyrazoles by using Mn doped ZrO2, HPLC of Formula: 86-51-1, the main research area is pyranopyrazole carboxylate preparation green chem ultrasound; dimethylacetylenedicarboxylate malononitrile benzaldehyde hydrazine hydrate coupling zirconium oxide catalyst; carbonitrile pyranopyrazole preparation green chem ultrasound; acetoacetate malononitrile benzaldehyde hydrazine hydrate coupling zirconium oxide catalyst.

Mn doped zirconia is utilized as an environment-friendly and efficient catalyst for an ultrasound mediated four-component coupling reaction, containing dimethylacetylenedicarboxylate/ethyl acetoacetate, hydrazine hydrate, malononitrile, and aromatic aldehyde RC6H4CHO [R = 2-F, 4-Br, 3-OH, 2-OCH3, 2,3-(OCH3)2, 2,5-(OCH3)2, 2,4,6-(OCH3)3]. These reactions were performed under green solvent conditions, to yield pyrano[2,3-c]pyrazole-3-carboxylate derivatives I [R1 = C(O)OCH3] and pyrano[2,3-c]pyrazole-5-carbonitrile derivatives I (R1 = CH3) with good to excellent yields (88-98%). The main benefits of this process are short reaction times, easy work-up, reusability of the catalyst and no chromatog. purifications.

Arabian Journal of Chemistry published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, HPLC of Formula: 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Akpotu, Samson O. published the artcileCitric Acid/MCM-48 Catalyzed Multicomponent Reaction: An Efficient Method for the Novel Synthesis of Quinoline Derivatives, Computed Properties of 86-51-1, the main research area is citric acid doped MCM heterogeneous catalyst preparation; hexahydroquinoline green preparation; aldehyde cyclohexanedione malononitrile ammonium acetate multicomponent citro MCM catalyst.

A facile, efficient and suitable green approach was designated for the one-pot synthesis of quinoline derivatives in the presence of citric acid doped MCM-48 (CAMCM-48) as a heterogeneous catalyst. The prepared material was characterized by using various techniques like P-XRD, SEM, TEM, TGA, FTIR and structural properties was determined by BET anal. Reaction progressed efficiently under ethanol solvent system at room temperature to afford the corresponding products. This protocol offered many advantages such as simple synthesis, easy work-up, short reaction times (15 min), good stability, reusability and no chromatog. separation techniques plus excellent yields (91-98%).

ChemistrySelect published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Computed Properties of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kurteva, Vanya published the artcileConstrained 1-Phenylethyl Amine Analogues as Chiral Auxiliaries in Stereoselective trans-β-Lactam Formation via Staudinger Cycloaddition, Category: isoquinoline, the main research area is lactam beta constrained phenylethyl preparation stereoselective Staudinger cycloaddition.

The efficiency of enantiomeric 1-aminoindane and 1,2,3,4-tetrahydro-1-naphthylamine as chiral auxiliaries in trans-ss-lactam formation via Staudinger cycloaddition is examined Aromatic aldehydes possessing one, two, or three methoxyl groups are used as imine precursors, and the influence of their number and position on the reaction output is studied. A comparison with the results obtained from 1-phenylethyl and 1-(2-naphthyl)ethylamine-derived imines is performed.

Journal of Heterocyclic Chemistry published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Khumalo, Mandlenkosi Robert published the artcileMicrowave-Assisted One-Step Four-Component Reaction for Synthesis of 1,4-Dihydropyridines Catalyzed by Triethylamine, Application In Synthesis of 86-51-1, the main research area is benzaldehyde benzyl acetoacetate methylcyclohexanedione ammonium acetate triethylamine catalyst condensation; benzyloxycarbonyl dimethylquinolinone preparation microwave irradiation green chem.

A green approach was designed for the synthesis of 1,4-dihydropyrine derivatives catalyzed by triethylamine with water as solvent and under microwave irradiation conditions. The title reaction involved the one-pot condensation of four components, namely aryl aldehyde, benzyl acetoacetate, 5-methyl-1,3-cyclohexanedione and ammonium acetate. Good to excellent yields (88-98%), short reaction times (10 min), green solvent and simple workup were attractive features for the approach. The method requires no further chromatog. separation The structures of all the ten new derivatives were fully characterized by spectroscopic anal. with 1H-NMR, 13C-NMR, 15N-NMR and HRMS.

ChemistrySelect published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application In Synthesis of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chehab, Soukaina published the artcileA facile and efficient synthesis of tetrahydrobenzo[b]pyrans and dihydropyrano[4,3-b]pyrans derivatives using phosphate fertilizers MAP, DAP, and TSP as heterogeneous catalysts, Category: isoquinoline, the main research area is benzaldehyde malononitrile dimethylcyclohexanedione heterogeneous catalyst three component condensation; tetrahydrobenzopyran preparation green chem; hydroxymethylpyranone benzaldehyde malononitrile heterogeneous catalyst three component condensation; dihydropyranopyran preparation green chem.

A simple and efficient one-pot synthesis of tetrahydrobenzo[b]pyrans and dihydropyrano[4,3-b]pyrans was described. These reactions were realized through a three-component condensation of aromatic aldehydes, malononitrile, and 5,5-dimethyl-1,3-cyclohexanedione or 4-hydroxy-6-methylpyran-2-one using phosphate fertilizers monoammonium phosphate, NH4(H2PO4)2, (MAP), diammonium phosphate, (NH4)2(HPO4), (DAP), and triple superphosphate, Ca(H2PO4)2.H2O, (TSP) as heterogeneous catalysts. Under optimal reaction conditions, these fertilizers showed an excellent catalytic activity. Indeed, the tetrahydrobenzo[b]pyrans and dihydropyrano[4,3-b]pyrans were obtained with good yields in short reaction times. Also, these fertilizers was reused at least four times without significant loss of their catalytic activity. Therefore, their application contributed to the development of green chem.

Journal of the Iranian Chemical Society published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Harutyunyan, A. A. published the artcileOne-Pot Syntheses with 2-Substituted 6-Aminopyrimidin-4(3H)-ones: New 5-Aryl-5,8,9,10-tetrahydropyrimido[4,5-b]-quinoline-4,6(3H,7H)-diones and 5,5′-(Arylmethylene)-bis[6-amino-2-methylpyrimidin-4(3H)-ones], Safety of 2,3-Dimethoxybenzaldehyde, the main research area is aryl tetrahydropyrimidoquinolinedione preparation green chem; aminopyrimidinone aromatic aldehyde dimethylcyclohexanedione condensation; arylmethylene bis aminomethylpyrimidinone preparation green chem; methyl aminopyrimidinone aromatic aldehyde condensation.

One-pot condensation of 2-substituted 6-aminopyrimidin-4(3H)-ones I (R = Me, NH2, OH) with aromatic aldehydes R1CHO (R1 = 4-(dimethylamino)phenyl, 2-hydroxy-3-methoxyphenyl, 4-(benzyloxy)phenyl, etc.) and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in acetic acid without a catalyst afforded new substituted 5-aryl-5,8,9,10-tetrahydropyrimido[4,5-b]quinoline-4,6(3H,7H)-diones II in good yields. The condensation of 2-methyl-6-aminopyrirnidin-4(3H)-one with aromatic aldehydes R2CHO (R2 = 2,3-dimethoxyphenyl, 4-bromophenyl, 1,3-benzodioxol-5-yl, etc.) at a molar ratio of 2:1 under similar conditions led to the exclusive formation of uncyclized 5,5′-(arylmethylene)bis[6-amino-2-methylpyrimidin-4(3H)-ones] III.

Russian Journal of Organic Chemistry published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Safety of 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tzani, Andromachi published the artcileGreen synthesis of bis-(β-dicarbonyl)-methane derivatives and biological evaluation as putative anticandidial agents, Product Details of C9H10O3, the main research area is biscoumarin green preparation antifungal; bisquinolinone green preparation antifungal; benzaldehyde dicarbonyl compound tandem Knoevenagel Michael.

The effectiveness of two different reaction media, an ionic liquid (IL) and a deep eutectic solvent (DES), as greener, alternative solvents for the synthesis of bioactive bis-(β-dicarbonyl)-methane derivatives I [R1 = H, OH, OMe, Cl; R2 = H, OH, OMe; R3 = H, Cl; X = O, NH, NMe] was examined A domino Knoevenagel-Michael reaction between aromatic aldehydes and heterocyclic 1,3-dicarbonyl compounds was successfully accomplished, producing the desired compounds I in satisfactory yields. The solvents were recycled and reused three times without noticeable decrease in reaction yields. A putative conformation of compound I [R1 = OMe, R2 = R3 = H, X = NMe] was determined using NMR spectroscopy and an ”anti” orientation of the fused aromatic rings was proposed. Moreover, some of the bis-(β-dicarbonyl)-methane derivatives I were tested for their antifungal activity against four Candida albicans strains. The biscoumarin I [R1 = H, R2 = R3 = OMe, X = O] and bisquinolinone I [R1 = OH, R2 = OMe, R3 = H, X = NMe] exhibited promising anticandidial activity. In parallel, in silico ligand-based similarity calculations provided a putative mechanism of action of the examined compounds through CYP51 inhibition.

Journal of Molecular Structure published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Product Details of C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jones, Roderick C. published the artcileControlling reactivity in the Fujiwara-Moritani reaction: Examining solvent effects and the addition of 1,3-dicarbonyl ligands on the oxidative coupling of electron rich arenes and acrylates, Computed Properties of 151-10-0, the main research area is Fujiwara Moritani dicarbonyl ligand oxidative coupling arene acrylate solvent.

A palladium-catalyzed direct alkenylation of electron rich arenes in the presence of K2S2O8 with an acetic acid/1,4-dioxane solvent combination was developed. The 1,4-dioxane co-solvent dramatically influences the rate of reaction, giving selectively disubstituted alkenes, while the addition of acetylacetone ligands increases site selectivity for the alkenylation of monofunctionalized arenes. The participation of these carbonyl ligands was confirmed by ESI-MS studies, with some key in situ intermediates in the catalytic cycle identified. A variety of electron rich arenes and olefinic substrates can be used in the direct oxidative coupling to give disubstituted alkenes in moderate to good yields.

Tetrahedron Letters published new progress about 1,3-Dicarbonyl compounds Role: CAT (Catalyst Use), USES (Uses). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Barysevich, Maryia V. published the artcilePalladium-Catalyzed 2-(Neopentylsulfinyl)aniline Directed C-H Acetoxylation and Alkenylation of Arylacetamides, Formula: C9H10O3, the main research area is aryl acetamide regioselective acetoxylation diacetoxyiodobenzene palladium catalyst; acetoxy arylacetamide preparation; cyclopropanol stereoselective regioselective alkenylation arylacetamide palladium catalyst; alkenyl arylacetamide preparation.

The 2-(neopentylsulfinyl)aniline directing group that promotes rapid palladium-catalyzed C-H acetoxylation and alkenylation of arylacetamides has been developed. The acetoxylation reached completion within only 40 min at 100°C and led to the bis-functionalized products. Alternatively, the reaction can be carried out at room temperature, which is beneficial for sensitive substrates. For the alkenylation, a protocol has been developed where easily available 1-substituted cyclopropanols were employed as equivalent of vinyl ketones.

European Journal of Organic Chemistry published new progress about Acetates Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Xiong published the artcileFullerotetrahydroquinolines: TfOH/TsOH · H2O-Mediated One-Pot Two-Step Synthesis and N-Alkylation/Acylation/Carboamidation Reaction, Synthetic Route of 5961-59-1, the main research area is fullerene amine paraformaldehyde alkylation acylation carboamidation toluenesulfonic trifluoromethanesulfonic acid; fullerotetrahydroquinoline one pot preparation.

A series of N-unsubstituted/substituted fullerotetrahydroquinolines without a directly attached nitrogen atom were synthesized in moderate to good yields via a one-pot two-step reaction of [60]fullerene with arylamines and paraformaldehyde in the presence of trifluoromethanesulfonic acid and p-toluenesulfonic acid monohydrate. Aromatic primary amines produce N-unsubstituted fullereotetrahydroquinolines, while aromatic secondary amines give N-substituted fullereotetrahydroquinoline derivatives As precursors, N-unsubstituted fullerotetrahydroquinolines could be further derivatized by the N-alkylation/acylation/carboamidation reactions to produce a large variety of N-substituted fullerotetrahydroquinolines containing Cl, NO2, C(O), and C(O)NH functional groups, which may have applications in the field of perovskite-based solar cells. Plausible reaction pathways for the formation of N-unsubstituted/substituted fullerotetrahydroquinolines were suggested to elucidate the above-mentioned reaction process.

Advanced Synthesis & Catalysis published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem