Tzani, Andromachi published the artcileGreen synthesis of bis-(β-dicarbonyl)-methane derivatives and biological evaluation as putative anticandidial agents, Product Details of C9H10O3, the main research area is biscoumarin green preparation antifungal; bisquinolinone green preparation antifungal; benzaldehyde dicarbonyl compound tandem Knoevenagel Michael.
The effectiveness of two different reaction media, an ionic liquid (IL) and a deep eutectic solvent (DES), as greener, alternative solvents for the synthesis of bioactive bis-(β-dicarbonyl)-methane derivatives I [R1 = H, OH, OMe, Cl; R2 = H, OH, OMe; R3 = H, Cl; X = O, NH, NMe] was examined A domino Knoevenagel-Michael reaction between aromatic aldehydes and heterocyclic 1,3-dicarbonyl compounds was successfully accomplished, producing the desired compounds I in satisfactory yields. The solvents were recycled and reused three times without noticeable decrease in reaction yields. A putative conformation of compound I [R1 = OMe, R2 = R3 = H, X = NMe] was determined using NMR spectroscopy and an ”anti” orientation of the fused aromatic rings was proposed. Moreover, some of the bis-(β-dicarbonyl)-methane derivatives I were tested for their antifungal activity against four Candida albicans strains. The biscoumarin I [R1 = H, R2 = R3 = OMe, X = O] and bisquinolinone I [R1 = OH, R2 = OMe, R3 = H, X = NMe] exhibited promising anticandidial activity. In parallel, in silico ligand-based similarity calculations provided a putative mechanism of action of the examined compounds through CYP51 inhibition.
Journal of Molecular Structure published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Product Details of C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem