Category: isoquinoline

Shigeno, Masanori published the artcileCatalytic Amination of β-(Hetero)arylethyl Ethers by Phosphazene Base t-Bu-P4, Category: isoquinoline, the main research area is arylethyl ether amine amination phosphazene; amine preparation; phosphazene amination catalyst.

The catalytic amination of β-(hetero)arylethyl ethers with amines using the organic superbase t-Bu-P4 to obtain β-(hetero)arylethylamines, is described. The reaction has a broad substrate scope and allows the transformations of electron-deficient and electron-neutral β-(hetero)arylethyl ethers with various amines including pyrrole, N-alkylaniline, diphenylamine, aniline, indole, and indoline derivatives Mechanistic studies indicate a two-reaction pathway of MeOH elimination from the substrate to form a (hetero)arylalkene followed by the hydroamination of the alkene.

Organic Letters published new progress about Amination. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Cheng, Hanchao published the artcilePhotoinduced Hydroarylation and Cyclization of Alkenes with Luminescent Platinum(II) Complexes, Computed Properties of 5961-59-1, the main research area is dihydroquinolinone preparation photoinduced hydroarylation cyclization aryl alkene halide; aryl halides; hydroarylation; intramolecular cyclization; photocatalysis; platinum.

Photoinduced hydroarylation of alkenes is an appealing synthetic strategy for arene functionalization. Herein, we demonstrated that aryl radicals generated from electron-deficient aryl chlorides/bromides could be trapped by an array of terminal/internal aryl alkenes in the presence of [Pt(ON̂ĈN̂)] under visible-light (410 nm) irradiation, affording anti-Markonikov hydroarylated compounds in up to 95% yield. Besides, a protocol for [Pt(ON̂ĈN̂)]-catalyzed intramol. photocyclization of acrylanilides to give structurally diverse 3,4-dihydroquinolinones has been developed.

Angewandte Chemie, International Edition published new progress about Aryl alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Luo, Xiai published the artcilePalladium-Catalyzed Domino Heck/C-H Activation/Decarboxylation: A Rapid Entry to Fused Isoquinolinediones and Isoquinolinones, Category: isoquinoline, the main research area is fused isoquinolinedione isoquinolinone preparation regioselective; alkene aryl iodide bromobenzoic acid domino cyclization palladium catalyst; carbon hydrogen activation Heck reaction decarboxylation.

A new palladium-catalyzed tandem cyclization of various alkene-tethered aryl iodides has been presented. In this protocol, o-bromobenzoic acids are employed as coupling parters to achieve the insertion of aromatic rings by the cleavage of C(sp2)-Br and decarboxylation, thus assembling various dibenzoisoquinolinediones and dibenzoisoquinolinones. In addition, a seven-membered ring can be constructed by the use of 8-bromo-1-naphthoic acid. Notably, this approach enables regioselective product formation and features broad substrate scope.

Organic Letters published new progress about Aryl iodides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (alkene-tethered). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Shuai published the artcileElectrochemical aziridination of tetrasubstituted alkenes with ammonia, Application of 4-Methoxyphenylacetic acid, the main research area is aziridine preparation; alkene ammonia electrochem aziridination.

Ammonia (NH3) is an ideal nitrogen source in terms of availability, reactivity, safety, atom economy, environmental compatibility, and ease of isolation. However, its utility for amine synthesis is limited by its high bond dissociation energy, its strong coordination ability, and the difference between its reactivity and that of the product amines. Herein, authors reported the first electrochem. protocol for direct syntheses of unprotected tetrasubstituted aziridines with NH3 and alkenes in the absence of an oxidant, which are highly challenging to achieve by other methods. The combination of graphite felt as the anode material and MeOH as the solvent was the key to the success of the protocol, and the effects of these factors were investigated by means of cyclic voltammetry and d. functional theory calculations

CCS Chemistry published new progress about Aziridination. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ma, Biao published the artcileEfficient Synthesis of Spirooxindole Pyrrolones by a Rhodium(III)-Catalyzed C-H Activation/Carbene Insertion/Lossen Rearrangement Sequence, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is olefin diazo oxindole rhodium catalyst domino annulation bond activation; spirooxindole pyrrolone preparation; carbene insertion Lossen rearrangement nucleophilic addition; C−H activation; Lossen rearrangement; olefins; oxindoles; rhodium catalysis.

A rhodium(III)-catalyzed domino annulation of simple olefins with diazo oxindoles to give spirooxindole pyrrolone products is described. This reaction can be formally viewed as the result of an anomalous tandem C-H activation, carbene insertion, Lossen rearrangement, and a nucleophilic addition process. The potential utility of this reaction was further demonstrated by the late-stage diversification of drug mols.

Angewandte Chemie, International Edition published new progress about C-H bond activation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Feng, Yunxia published the artcileIntermolecular alkene arylcyanation using BnSCN as a cyanide source via a reductive strategy: access to 3,3-disubstituted oxindoles, Application of 4-Methoxyphenylacetic acid, the main research area is oxindole preparation; alkene benzyl thiocyanate reductive intermol arylcyanation nickel catalyst.

Herein, a nickel-catalyzed two-component reductive arylcyanation of aryl (pseudo)halide tethered alkenes using benzyl thiocyanate as the cyanide source via C-S bond activation is developed. Using this protocol, a wide scope of 3,3-disubstituted oxindoles bearing all-carbon quaternary stereocenters are accessible in moderate to excellent yields. The preliminary mechanistic investigations reveal that a Ni(I)/Ni(III) process might be involved in the mechanism.

Organic Chemistry Frontiers published new progress about Cyanation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Muralirajan, Krishnamoorthy published the artcileExploring the Structure and Performance of Cd-Chalcogenide Photocatalysts in Selective Trifluoromethylation, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is trifluoromethylated arene oxindole alkene preparation photochem; heteroarene alkene selective trifluoromethylation cadmium selenide catalyst.

The field of heterogeneous photoredox catalysis has grown substantially and impacted organic synthesis because of the affordability and reusability of catalysts. This study reports radical trifluoromethylation with Cd-chalcogenide semiconductors. Cd semiconductors, particularly CdSe, are readily available, com., visible-light-responsive, heterogeneous photocatalysts. The potential of readily available Cd semiconductors, particularly CdSe, is confirmed by their increased photocatalytic activity toward trifluoromethylation with various substrates, such as (hetero)arenes and vinylic amides/acids, via addition, cyclization, and decarboxylation under visible light. The economic significance of this strategy is also highlighted through the scalable synthesis of biol. active mols. followed by catalyst reuse. Moreover, these catalysts are relatively inexpensive compared with transition metal-based homogeneous photocatalysts, presently used in organic synthesis.

ACS Catalysis published new progress about Cyclization. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kim, Myeong Jin published the artcileOxoammonium salt-mediated oxidative nitriles synthesis from aldehydes with ammonium acetate, Category: isoquinoline, the main research area is nitrile preparation; aldehyde ammonium acetate oxoammonium salt oxidation.

An efficient and scalable route for the synthesis of nitriles I [R = n-heptyl, cyclohexyl, 4-MeOC6H4, 2-thienyl, etc.] was developed by oxoammonium salt (4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate) mediated oxidative conversion of aldehydes with ammonium acetate (NH4OAc). A variety of aliphatic aldehydes as well as benzaldehydes were converted into the corresponding nitriles in high yields. The nitroxyl radical which was the reduced species of the used oxoammonium salt was recovered by simple acid-base extraction for the recycling.

Tetrahedron Letters published new progress about Nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Higham, Joe I. published the artcileCopper catalysed oxidative α-sulfonylation of branched aldehydes using the acid enhanced reactivity of manganese(IV) oxide, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is alpha sulfonyl aldehyde preparation; branched aldehyde sulfinate salt oxidative sulfonylation copper catalyst.

The oxidative coupling of secondary aldehydes and sulfinate salts is achieved using copper catalysis to form α-sulfonyl aldehydes. The use of an acidic co-solvent is important to adjust the oxidation potential of MnO2 as an oxidant. A broad range of sulfonylated aldehydes is prepared, and their further functionalisation is demonstrated. A dual ionic/radical pathway mechanism is proposed.

Chemical Communications (Cambridge, United Kingdom) published new progress about Sulfinates Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sokolov, Anatolii I. published the artcileConvenient and Versatile Synthetic Protocol for Arylidene-1H-imidazol-5(4H)-ones, Computed Properties of 104-01-8, the main research area is arylacetamidoacetate alkylimino benzylidene alkylation diastereoselective cycloaddition; aryl benzylidene alkylimidazolone preparation; benzylidene benzoyl methylimidazolone preparation.

A new protocol for synthesis of the arylidene-1H-imidazol-5(4H)-ones based on O-alkylation of amidoacetates using triethyloxonium tetrafluoroborate leading to carboximidates was proposed. These imidates have long been used in the synthesis of imidazolones by [2+3] cycloaddition reaction with Schiff bases. However, diversity of carboximidates prepared by the common techniques was limited. The protocol proposed here eliminated these limitations. Using this technique, a number of derivatives of the green fluorescent protein (GFP) and as FP chromophores were synthesized, and influence of the C2 residue on their optical properties was studied.

ChemistrySelect published new progress about Alkylation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem