Category: isoquinoline

On June 1, 2006, Yamada, Rintaro; Seto, Minoru published a patent.Application In Synthesis of 4-Bromo-5-nitroisoquinoline The title of the patent was Preparation of diazaphenalene derivatives as myosin-control light chains phosphorylation inhibitors. And the patent contained the following:

Title compounds I [R1, R5-R8 = H, halo, hydroxy, etc.; X1···X2 = -CH(R2)CH(R3)-, -CH(R2)CH(R3)CH(R4)-, -C(R2):C(R3)-, etc.; R2-R4 = H, alkyl; A1, A11, A2, A21 = H, alkyl; Y = -CH(A3)-, -CH(A3)C(A4)(A41)-, single bond, etc.; A3, A4, A41 = H, alkyl; Z = hydroxy, -NR(A6)(A61); A6 = H, alkyl; A61 = H, alkyl, alkyl substituted with aryl group, etc.; further details on A1-A4 and A6 are given.] and salts thereof were prepared For example, reductive amination of tert-Bu 3-oxo-1-piperidinecarboxylate with 5-amino-4-vinylisoquinoline, e.g., prepared from 5-amino-4-bromoisoquinoline, followed by reaction with potassium tert-butoxide and treatment with HCl afforded compound II hydrochloride. In myosin-control light chains phosphorylation inhibition assays, compound II hydrochloride exhibited the IC50 value of ≤10 μM. Compounds I are claimed useful for the treatment of glaucoma, bronchial asthma, etc. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Application In Synthesis of 4-Bromo-5-nitroisoquinoline

The Article related to diazaphenalene preparation myosin control light chain phosphorylation inhibitor, glaucoma bronchial asthma treatment diazaphenalene preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 4-Bromo-5-nitroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On December 28, 2000, Nichols, David E.; Grubbs, Russell A.; Mailman, Richard B. published a patent.Electric Literature of 58142-46-4 The title of the patent was Preparation of chromeno[4,3,2-de]isoquinolines as potent dopamine receptor ligands. And the patent contained the following:

The title compounds I [R1, R2, R3 = H, alkyl, alkenyl; R8 = H, alkyl, phenoxy protecting group; X9 = H, halo, OR where R = H, alkyl, phenoxy protecting group, etc.; R4, R5, R6 = H, alkyl, Ph, halo, OR], potent dopamine receptor ligands, were prepared E.g., N-propyl-8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2-de]isoquinoline was prepared The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Electric Literature of 58142-46-4

The Article related to chromenoisoquinoline preparation dopamine receptor ligand, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Electric Literature of 58142-46-4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On November 25, 2015, Wu, Lingyun; Yao, Yuanshan; Chen, Zhaoguo; Chen, Shuhui published a patent.Quality Control of 4-Bromo-5-nitroisoquinoline The title of the patent was Preparation of isoquinolinesulfonyl derivatives as Rho kinase inhibitors. And the patent contained the following:

The invention relates to isoquinolinesulfonyl derivatives (e.g., I) and their pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical preparations comprising them, and their use as Rho kinase inhibitors. For instance, the invention compound I was prepared and gave a ROCK kinase inhibition IC50 value of <0.1μM. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Quality Control of 4-Bromo-5-nitroisoquinoline

The Article related to isoquinolinesulfonyl preparation rho kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Quality Control of 4-Bromo-5-nitroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On November 5, 2015, Wu, Lingyun; Yao, Yuanshan; Chen, Zhaoguo; Chen, Shuhui published a patent.SDS of cas: 58142-46-4 The title of the patent was Preparation of isoquinolinesulfonyl derivatives as Rho kinase inhibitors. And the patent contained the following:

The invention relates to isoquinolinesulfonyl derivatives (e.g., I) and their pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical preparations comprising them, and their use as Rho kinase inhibitors. For instance, the invention compound I was prepared and gave a ROCK kinase inhibition IC50 value of <0.1μM. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).SDS of cas: 58142-46-4

The Article related to isoquinolinesulfonyl preparation rho kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.SDS of cas: 58142-46-4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On February 28, 2008, Lautens, Mark; Yuen, Josephine; Fang, Yuanqing published a patent.Application of 1009104-85-1 The title of the patent was Process for preparation of pyrrole derivatives. And the patent contained the following:

The present invention pertains to processes for the chem. synthesis of pyrrole derivatives, particularly azaindole and thienopyrrole compounds that are substituted at the 2-position of the azaindole or thienopyrrole ring. For example, to a mixture of 3-(2,2-dibromoethenyl)-N-methyl-2-pyridinamine (preparation given), phenylboronic acid, and K3PO4•H2O under argon was added a solution of Pd(OAc)2 and S-Phos in toluene. The reaction was heated to 100 °C for 2 h., then cooled to room temperature, worked-up with saturated NaHCO3 solution, extracted with Et2O, dried over Na2SO4, and concentrated in vacuo. The crude material was purified using chromatog. eluting with 25 % EtOAc/hexane to yield the product, 1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine, as a white solid in 84% yield. 1-Methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine obtained above can be used for the preparation of com. important azaindole compounds as pharmaceutical agents. The experimental process involved the reaction of 1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one(cas: 1009104-85-1).Application of 1009104-85-1

The Article related to preparation pyrrolopyridine thienopyrrole azaindole, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application of 1009104-85-1

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On July 31, 1992, Werra, W.; Heber, D. published an article.Product Details of 58142-46-4 The title of the article was 1H and 13C NMR studies of substituted isoquinolinium derivatives in different solvents. And the article contained the following:

1H and 13C NMR data for 1-cyano-, 4-cyano-, 4-bromo- and 4-bromo-5-nitro-substituted isoquinolines, isoquinoline N-oxides and N-methoxy and N-Et salts in different solvents are reported. The substituent chem. shifts are discussed with regard to the reactivity of the N-methoxy compounds in the presence of nucleophilic reagents. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Product Details of 58142-46-4

The Article related to nmr isoquinolinium compound solvent effect, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Product Details of 58142-46-4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On November 30, 1989, Volovenko, Yu. M.; Litvinenko, S. V.; Babichev, F. S. published an article.Computed Properties of 58142-46-4 The title of the article was Annulation of benzoindolizine rings to quinoxaline nucleus. And the article contained the following:

Quinoxalineacetonitriles I (R3 = Me, Ph, or 4-MeC6H4) react with isoquinolines II (R1 = H, R2 = H, NO2; R1 = Br, R2 = NO2) 2-4 h in DMF at 160° or reflux to give quant. benzindolizinoquinoxalines III. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Computed Properties of 58142-46-4

The Article related to benzindolizinoquinoxalinecarbonitrile, indolizinoquinoxaline benz, quinoxaline benzindolizino, isoquinoline quinoxalineacetonitrile reaction, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Computed Properties of 58142-46-4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On July 6, 2021, Yu, Hongtao; Hu, Qi; Huang, Jing; Wang, Tingliang; Hou, Ningke; Zhang, Lijing; Zhang, Wenyi; Tan, Qiaozhu published a patent.Synthetic Route of 1378839-26-9 The title of the patent was Preparation of heterocyclic derivatives as 3C like protease inhibitors. And the patent contained the following:

The invention relates to the preparation of heterocyclic derivatives with general formula I as 3C like protease inhibitors, where Ar = Ph or 6-membered heteroaryl; ring A = 9 or 10-membered heteroaryl, wherein: V1 , V2, V3, and V4 = not present, CH or N; and at most one of V1, V2, V3, and V4 may not exist; when one of W1, W2, W3, and W4 does not exist, then V1, V2, V3, and None of V4 can be absent; W1, W2, W3, and W4 = not present, CH or N; at most one of W1, W2, W3, and W4 can be absent; at least one of W1, W2, W3, and W4 must be N; X = absent, NRa or NRa(CRbRc)a; Y = absent, C3-C12 carbocyclyl, 3-12 membered heterocyclic group, or 5-10 membered heteroaryl; Z = absent, NRd, (CReRf)bNRd or C(=O)NRd(CRgRh)c; Ra and Rd = hydrogen or C1-C4 alkyl; Rb, Rc, Re and Rf = hydrogen or substituted C1-C4 alkyl; Rg and Rh = hydrogen or substituted C1-C4 alkyl; Ri and Rj = hydrogen or C1-C4 alkyl; a, b and c = 1, 2, 3 or 4; R1, R2. And R3 = halogen, cyano, C1-C6 alkane Group, C2-C6 alkenyl, C1-C6 alkoxy, C(=O)(C1-C6 alkyl), C(=O)NRpRq, NRpRq, NRpC(=O)Rs, NRpC(=O)ORs , NRpC(=O)NRqRr, NRpS(=O)wRs, NO2, NO2+, NH(=O)OH, ORs, OC(=O)Rs, OC(=O)ORs, OC(=O)NRpRq, S(=O)wRs, S(=O)wNRpRq, SO3, C3-C12 carbocyclic group, 3-12 membered heterocyclic group, Ph, 5-10 membered heteroaryl; Rp, Rq and Rr = hydrogen, C1-C4 alkyl or C3-C6 cycloalkyl; Rs = hydrogen, C1-C4 alkyl or C3-C6 cycloalkyl; m = 0 For example, 5-bromo-2-((1-(5-hydroxyisoquinoline-4-carbonyl)piperidin-3-yl)amino)-N-methyl-3-nitrobenzamide was prepared by a multi-step reaction. The title compounds have good inhibitory effect on 3C like protease and can be used to treat SARS-COV-2 infection. The experimental process involved the reaction of 7-Hydroxyisoquinoline-4-carboxylic acid(cas: 1378839-26-9).Synthetic Route of 1378839-26-9

The Article related to amidation coupling hydrolysis preparation piperazine isoquinoline treatment human coronavirus, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Synthetic Route of 1378839-26-9

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem