On February 28, 2008, Lautens, Mark; Yuen, Josephine; Fang, Yuanqing published a patent.Application of 1009104-85-1 The title of the patent was Process for preparation of pyrrole derivatives. And the patent contained the following:
The present invention pertains to processes for the chem. synthesis of pyrrole derivatives, particularly azaindole and thienopyrrole compounds that are substituted at the 2-position of the azaindole or thienopyrrole ring. For example, to a mixture of 3-(2,2-dibromoethenyl)-N-methyl-2-pyridinamine (preparation given), phenylboronic acid, and K3PO4•H2O under argon was added a solution of Pd(OAc)2 and S-Phos in toluene. The reaction was heated to 100 °C for 2 h., then cooled to room temperature, worked-up with saturated NaHCO3 solution, extracted with Et2O, dried over Na2SO4, and concentrated in vacuo. The crude material was purified using chromatog. eluting with 25 % EtOAc/hexane to yield the product, 1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine, as a white solid in 84% yield. 1-Methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine obtained above can be used for the preparation of com. important azaindole compounds as pharmaceutical agents. The experimental process involved the reaction of 1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one(cas: 1009104-85-1).Application of 1009104-85-1
The Article related to preparation pyrrolopyridine thienopyrrole azaindole, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application of 1009104-85-1
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem