Tag: 100-200

On November 22, 2017, Fish, Inbar; Stossel, Anne; Eitel, Katrin; Valant, Celine; Albold, Sabine; Huebner, Harald; Moller, Dorothee; Clark, Mary J.; Sunahara, Roger K.; Christopoulos, Arthur; Shoichet, Brian K.; Gmeiner, Peter published an article.Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one The title of the article was Structure-Based Design and Discovery of New M2 Receptor Agonists. And the article contained the following:

Muscarinic receptor agonists are characterized by apparently strict restraints on their tertiary or quaternary amine and their distance to an ester or related center. On the basis of the active state crystal structure of the muscarinic M2 receptor in complex with iperoxo, the authors explored potential agonists that lacked the highly conserved functionalities of previously known ligands. Using structure-guided pharmacophore design followed by docking, the authors found two agonists (compounds 3 (2-(3-methoxyphenyl)-N,N,N-trimethylethan-1-aminium formate) and 17 (2-(benzofuran-6-yl)-N,N,N-trimethylethan-1-aminium formate)), out of 19 docked and synthesized compounds, that fit the receptor well and were predicted to form a hydrogen-bond conserved among known agonists. Structural optimization led to compound 28 (2-(2,3-dihydrobenzofuran-6-yl)-N,N,N-trimethylethan-1-aminium formate), which was 4-fold more potent than its parent 3. Fortified by the discovery of this new scaffold, the authors sought a broader range of chemotypes by docking 2.2 million fragments, which revealed another three micromolar agonists unrelated either to 28 or known muscarinics. Even pockets as tightly defined and as deeply studied as that of the muscarinic reveal opportunities for the structure-based design and the discovery of new chemotypes. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

The Article related to muscarinic m2 receptor agonist structure based design preparation docking, Pharmacology: Structure-Activity and other aspects.Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On January 10, 2013, Frackenpohl, Jens; Zeiss, Hans-Joachim; Heinemann, Ines; Willms, Lothar; Mueller, Thomas; Busch, Marco; Von Koskull-Doering, Pascal; Rosinger, Christopher Hugh; Dittgen, Jan; Hills, Martin Jeffrey published a patent.SDS of cas: 74904-29-3 The title of the patent was Use of substituted isoquinolinones, isoquinolinediones, isoquinolinetriones and dihydroisoquinolinones or in each case salts thereof as active agents against abiotic stress in plants and their preparation. And the patent contained the following:

The invention relates to the use of substituted isoquinolinones, isoquinolinediones, isoquinolinetriones and dihydroisoquinolinones of formula I or in each case salts thereof, for enhancing stress tolerance in plants against abiotic stress, for boosting plant growth and/or for increasing plant yield, and to special methods for producing the aforementioned compounds Compounds of formula I wherein Q is (un)substituted ethylene, (un)substituted ethenylene, (un)substituted oxoethylene, etc.; W is O and S; R1, R2, R3 and R4 are independently H, NO2, amino, OH, halo, etc.; R5 is H, OH, alkyl, cycloalkyl, etc.; and their salts are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their ability to protect against abiotic stress in plants (some data given). The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).SDS of cas: 74904-29-3

The Article related to isoquinolinone isoquinolinedione isoquinolinetrione preparation protection abiotic stress plant, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.SDS of cas: 74904-29-3

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On July 1, 2006, Jesudason, Cynthia D.; Beavers, Lisa S.; Cramer, Jeffrey W.; Dill, Joelle; Finley, Don R.; Lindsley, Craig W.; Stevens, F. Craig; Gadski, Robert A.; Oldham, Samuel W.; Pickard, R. Todd; Siedem, Christopher S.; Sindelar, Dana K.; Singh, Ajay; Watson, Brian M.; Hipskind, Philip A. published an article.COA of Formula: C10H11NO2 The title of the article was Synthesis and SAR of novel histamine H3 receptor antagonists. And the article contained the following:

The synthesis and biol. evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H3 receptors are described. The substitution around these rings as well as the nature of the substituent on nitrogen is explored. Several compounds with high affinity and selectivity for the human and rat H3 receptors are reported. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).COA of Formula: C10H11NO2

The Article related to h3 antihistaminic tetrahydroisoquinoline tetrahydroquinoline tetrahydroazepine preparation, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.COA of Formula: C10H11NO2

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

In, Jinkyung; Hwang, Soonho; Kim, Changhun; Seo, Jae Hong; Kim, Sanghee published an article in 2013, the title of the article was Synthesis of 3,4-Dihydroisoquinolin-1-ones from N-Boc-(β-Arylethyl)carbamates via Isocyanate Intermediates.Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one And the article contains the following content:

Mild reaction conditions for the regioselective synthesis of isoquinolin-1-ones and related fused-ring heterocycles from N-Boc-protected (β-arylethyl)carbamates are described. The reactions involved the use of Tf2O and 2-chloropyridine and isocyanates are likely to be key intermediates. The method was extended to substrates bearing less nucleophilic aryl moieties by using Lewis acid additives, such as BF3·Et2O, to enhance the Friedel-Crafts-type cyclization of the isocyanate intermediates. This method allowed the synthesis of various substituted isoquinolin-1-ones, β-carbolines, thiophene-fused ring systems and tetrahydrobenzoazepin-1-ones in good yields and with high regioselectivities. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

The Article related to dihydroisoquinolinone synthesis arylethylcarbamate isocyanate intermediate cyclization, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On March 31, 1980, Umezawa, Bunsuke; Hoshino, Osamu; Sawaki, Shohei; Mori, Kazuhiko published an article.Computed Properties of 74904-29-3 The title of the article was A cyclization of β-arylethylisocyanates to 3,4-dihydroisocarbostyrils. And the article contained the following:

Isocyanates derived from I (R1 = R4 = H, R2R3 = OCH2O, R2 = R3 = MeO, R2 = MeO, R3 = PhCH2O, R2 = PhCH2O, R3 = MeO; R1 = H, R2 = R3 = R4 = MeO; R1 = HO, R2 = MeO, R3 = HO, R4 = PhCH2; R1 = PhCH2, R2 = HO, R3 = MeO, R4 = H) cyclized on treatment with phosphoric acid to give the dihydroisocarbostyrils II. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Computed Properties of 74904-29-3

The Article related to isocarbostyril dihydro, phenethyl isocyanate cyclization, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Computed Properties of 74904-29-3

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On August 13, 2020, Milan, David J. published a patent.Related Products of 74904-29-3 The title of the patent was Treating long QT syndrome. And the patent contained the following:

This document relates to compounds useful for treating and preventing disorders associated with long QT syndrome such as cardiac arrhythmia, ventricular arrhythmia, hypertrophic cardiomyopathy, and congestive heart failure. Also provided herein are methods and materials for using such compounds to shorten myocardial repolarization time in a patient. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Related Products of 74904-29-3

The Article related to myocardial repolarization long qt syndrome therapy heart failure arrhythmia, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.Related Products of 74904-29-3

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kurouchi, Hiroaki; Otani, Yuko; Ohwada, Tomohiko published an article in 2016, the title of the article was Facile synthesis of 5- to 7-membered benzolactam compounds via strongly facilitated electrophilic aromtic substitution reaction.Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one And the article contains the following content:

Activation of aromatic ring-tethered carbamate compounds with trifluoromethanesulfonic acid to obtain benzolactams with 5- to 7-membered rings and examined the substrate scope and limitations of this activation method. In 5-membered ring formation, a halogen group on the aromatic ring did not greatly affect the reaction yield, but other electron-donating groups inhibited the cyclization reaction and various side-reactions occurred. In 7-membered ring formation, eletron-donating groups on aromatic ring promoted the cyclization reaction but cyclization of electron-deficient aromatic rings did not proceed well. The 6-membered ring formation reaction showed the greatest substrate generality. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

The Article related to aralkylcarbamoyloxy benzoate preparation triflic acid promoter electrophilic aromatic substitution, benzolactam preparation, Heterocyclic Compounds (One Hetero Atom): Higher-Membered Rings and other aspects.Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On July 28, 2022, Gu, Qiong; Xu, Jun; Fang, Yuying published a patent.Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one The title of the patent was Process for preparation of benzimidazole compound and application thereof in preparation of ferroptosis inhibitor. And the patent contained the following:

The invention relates to preparation of a benzimidazole compound, and an application thereof in preparation of a ferroptosis inhibitor. The benzimidazole compound has a structure as shown in formula I or II. According to the benzimidazole compound provided by the present invention, a lipophilic group is introduced to an R1 position, and a specific group is introduced to an R2 position, such that the obtained compound has relatively good ferroptosis inhibitory activity and can be used as a lead compound for preventing and treating nervous system diseases such as stroke. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

The Article related to benzimidazole compound preparation ferroptosis inhibitory, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On October 7, 2021, Cheruvallath, Zacharia; Green, Jason; Johnson, Ben; Jones, Bejamin; Schleicher, Kristin; Sun, Huikai; Tang, Mingnam published a patent.Application In Synthesis of 5-Methylisoquinoline-1-carbonitrile The title of the patent was N-Heteroarylalkyl-2-(heterocyclyl and heterocyclylmethyl) acetamide derivatives as SSTR4 agonists and their preparation. And the patent contained the following:

Disclosed are compounds of formula I, and pharmaceutically acceptable salts thereof. This disclosure also relates to materials and methods for preparing compounds of formula I, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with SSTR4. Compounds of formula I wherein when X3 is NH and derivatives and O, X4 is a single bond, and X5 is N and CR5, and R1R2 are taken together to form (un)substituted benzene ring; when X3 is CR3c, X4 is N and CR4, and X5 is N and CR5, and R1R2 are taken together to form (un)substituted furan, (un)substituted pyrazole or (un)substituted benzene ring; L is O when A is CHR6; L is a bond when n is absent and CHR6; R3c and N are independently H, halo, OH, CN, (un)substituted C3-6 cycloalkyl, etc.; R6 is H; R5R6 can be taken together to form ethane-1,2-diyl bridge; R7 and R8 are independently H and (un)substituted C1-4 alkyl; R9 is H and (un)substituted C1-4 alkyl; R10 is azetidin-1-ylmethyl, pyrrolidin-1-ylmethyl and heterocyclyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by amidation of 2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)acetic acid with 2-(1,7-dimethyl-1H-indazol-3-yl)propan-2-amine followed by hydrolysis; the resulting 7-(2-(1,7-dimethyl-1H-indazol-3-yl)propan-2-yl)-2-(pyrrolidin-2- yl)acetamide underwent reductive methylation with formaldehyde to give compound II. The invention compounds were evaluated for their SSTR4 inhibitory activity. From the assay, it was determined that compound II exhibited pEC50 value of 8.2 and pIC50 value of 7.2. The experimental process involved the reaction of 5-Methylisoquinoline-1-carbonitrile(cas: 1367744-24-8).Application In Synthesis of 5-Methylisoquinoline-1-carbonitrile

The Article related to heteroarylalkyl heterocyclylacetamide preparation sstr4 agonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Application In Synthesis of 5-Methylisoquinoline-1-carbonitrile

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On December 31, 1993, Shanker, P. Sathya; Rao, G. S. R. Subba published an article.Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one The title of the article was Synthesis of isoquinolines from indanones: total synthesis of illudinine. And the article contained the following:

Schmidt reaction of 5-methoxy or 7-methoxyindan-1-ones or their derivatives results exclusively in isocarbostyrils which are converted into 6-methoxy or 8-methoxyisoquinolines in good yields. This strategy has been extended to the total synthesis of illudinine Me ester (I) starting from hexahydroindacenecarboxylate II. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

The Article related to schmidt reaction methoxyindanone, amination ring expansion methoxyindanone, isoquinolinone tetrahydro, illudinine, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem