Tag: 207.27

Miyake, M. et al. published their research in Synthetic Communications in 1984 | CAS: 52250-50-7

1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Product Details of 52250-50-7

Synthesis of β-lactams by convenient annelation of imines was written by Miyake, M.;Tokutake, N.;Kirisawa, M.. And the article was included in Synthetic Communications in 1984.Product Details of 52250-50-7 This article mentions the following:

β-Lactams I (R = PhO, 4-ClC6H4O, phthalimido; R1 = PhCH:CH, Ph, 2-O2NC6H4CH:CH, 4-MeOC6H4; R2 = Ph, 4-ClC6H4, 2-ClC6H4, cyclohexyl) were prepared by acylating saccharin with RCH2COCl and treating the acyl derivatives II with R1CH:NR2. III (R = PhO, 4-ClC6H4O; R3 = 3-O2NC6H4, Ph, MeS, 4-O2NC6H4) were similarly obtained from II and 3,4-dihydroisoquinolines. In the experiment, the researchers used many compounds, for example, 1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7Product Details of 52250-50-7).

1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Product Details of 52250-50-7

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Scully, Frank E. Jr. et al. published their research in Heterocycles in 1982 | CAS: 52250-50-7

1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Safety of 1-Phenyl-3,4-dihydroisoquinoline

Synthesis of dihydroisoquinolines and 1-substituted tetrahydroisoquinolines was written by Scully, Frank E. Jr.;Schlager, John J.. And the article was included in Heterocycles in 1982.Safety of 1-Phenyl-3,4-dihydroisoquinoline This article mentions the following:

The tetrahydroisoquinolines I (R = H, Ph, Me) underwent N-chlorination-dehydrochlorination to give the dihydroisoquinolines II. II (R = H) underwent alkylation by reaction RLi or EtMgBr to give I (R = Me, Et, Bu, Ph, PhCH2). In the experiment, the researchers used many compounds, for example, 1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7Safety of 1-Phenyl-3,4-dihydroisoquinoline).

1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Safety of 1-Phenyl-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem