Miyake, M. et al. published their research in Synthetic Communications in 1984 | CAS: 52250-50-7

1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Product Details of 52250-50-7

Synthesis of β-lactams by convenient annelation of imines was written by Miyake, M.;Tokutake, N.;Kirisawa, M.. And the article was included in Synthetic Communications in 1984.Product Details of 52250-50-7 This article mentions the following:

β-Lactams I (R = PhO, 4-ClC6H4O, phthalimido; R1 = PhCH:CH, Ph, 2-O2NC6H4CH:CH, 4-MeOC6H4; R2 = Ph, 4-ClC6H4, 2-ClC6H4, cyclohexyl) were prepared by acylating saccharin with RCH2COCl and treating the acyl derivatives II with R1CH:NR2. III (R = PhO, 4-ClC6H4O; R3 = 3-O2NC6H4, Ph, MeS, 4-O2NC6H4) were similarly obtained from II and 3,4-dihydroisoquinolines. In the experiment, the researchers used many compounds, for example, 1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7Product Details of 52250-50-7).

1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Product Details of 52250-50-7

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem