Scully, Frank E. Jr. et al. published their research in Heterocycles in 1982 | CAS: 52250-50-7

1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Safety of 1-Phenyl-3,4-dihydroisoquinoline

Synthesis of dihydroisoquinolines and 1-substituted tetrahydroisoquinolines was written by Scully, Frank E. Jr.;Schlager, John J.. And the article was included in Heterocycles in 1982.Safety of 1-Phenyl-3,4-dihydroisoquinoline This article mentions the following:

The tetrahydroisoquinolines I (R = H, Ph, Me) underwent N-chlorination-dehydrochlorination to give the dihydroisoquinolines II. II (R = H) underwent alkylation by reaction RLi or EtMgBr to give I (R = Me, Et, Bu, Ph, PhCH2). In the experiment, the researchers used many compounds, for example, 1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7Safety of 1-Phenyl-3,4-dihydroisoquinoline).

1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Safety of 1-Phenyl-3,4-dihydroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem