Tag: 486-73-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.486-73-7,Isoquinoline-1-carboxylic acid,as a common compound, the synthetic route is as follows.

The crude residue obtained from the procedure herein above is combined with 1-isoquinolinecarboxylic acid (2.6 g, 15.0 mmol), HOBt (2.68 g, 19.8 [MMOL),] and EDCI (3.8 g, 19.8 [MMOL)] in DMF (20 mL). The solution is stirred for 3 hours at room temperature then diluted with EtOAc, washed with saturated [NAHCO3,] saturated NaCI, and dried (Na2SO4). The solvent is removed in vacuo and the residue obtained purified by HPLC to afford 1.7 g (40% yield) of the desired product NMR [(CDCI3)] 8 9.49-9. 46 (d, J=7.8 Hz, [1H),] 9.20-9. 18 (d, J=6.9 Hz, 1H), 8.52-8. 50 (d, J=5.5 Hz, [1H),] 7.86-7. 78 (m, 2H), 7.72-7. 63 (m, 2H), 5.79 (bs, [1H),] 5.55-5. 47 (m, [1H),] 4.76-4. 69 (d, d, [J=17.] 3,2. 3 Hz, [1H),] 4.45-4. 40 (d, [J=17.] 4 Hz, 1H), 4.25-4. 19 (d, [J=17.] 4 Hz, [1H),] 4.15-3. 98 (m, 3H), 3.73 (s, 3H), 3.65-3. 59 (d, [J=17.] 4 Hz, [1H),] 2.97-2. 90 (d, d, [J=18.] 2,3. 9 Hz, 1H), 2.48-2. 29 (m, 3H) [;’3C (CDCI3) S] 172.7, 170.5, 165.9, 148.2, 141.0, 137.7, 136.3, 130.7, 128.9, [127?7,] 127.2, 126.4, 124.7, 67.5, 60.8, 52.8, 50.3, 49.3, [48.] 1,32. 5,21. 4,14. 5; MS 384 (M+H) [+.]

The synthetic route of 486-73-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE PROCTER & GAMBLE COMPANY; WO2003/103677; (2003); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

486-73-7, Isoquinoline-1-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of carboxylic acid (1.0 mmol) in anhydrous THF (20 mL) were added (2S,3R)-2-amino-3-hydroxy-N-alkylbutanamide 4a-d (1.0 mmol) and HOBt (1.0 mmol, 0.135 g) at 0 C. After the reaction mixture was stirred for 5 min, EDC¡¤HCl (0.220 g, 1.1 mmol) was added. The pH value of the solution was adjusted to 8-9 with 4-methylmorpholine. The reaction mixture was stirred at 0 C for 2 h and overnight at room temperature. After evaporation of the mixture in vacuo, the residue was dissolved in ethyl acetate (50 mL). The solution was washed successively with saturated NaHCO3, 5% KHSO4, and saturated NaCl. The organic phase was separated and dried over anhydrous MgSO4. After filtration and evaporation in vacuo, residue was purified by recrystallization in petroleum ester/ethyl acetate to give the desired ceramide analogues 5xa-xj.

486-73-7 Isoquinoline-1-carboxylic acid 68092, aisoquinoline compound, is more and more widely used in various.

Reference£º
Article; Liu, Qianqian; Li, Xia; Bao, Yong-Sheng; Lu, Jingxin; Li, Hua; Huang, Zhizhen; Liu, Feiyan; Bioorganic and Medicinal Chemistry; vol. 27; 8; (2019); p. 1489 – 1496;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

486-73-7, Isoquinoline-1-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. 1,2,3,4-Tetrahydro-1-isoquinolinecarboxylic acid A solution of 1-isoquinolinecarboxylic acid (1.67 g) in glacial acetic acid (25 ml,) was hydrogenated at 60 p.s.i. over PtO2 (270 mg). When the reaction was complete, the mixture was filtered through diatomaceous earth (Celite), washing the solid pad with MeOH, and the filtrate was concentrated to dryness. The resultant white solid was triturated with cold water and filtered to provide the title compound (775 mg).

486-73-7 Isoquinoline-1-carboxylic acid 68092, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; ProScript, Inc.; US5780454; (1998); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem