With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.486-73-7,Isoquinoline-1-carboxylic acid,as a common compound, the synthetic route is as follows.
The crude residue obtained from the procedure herein above is combined with 1-isoquinolinecarboxylic acid (2.6 g, 15.0 mmol), HOBt (2.68 g, 19.8 [MMOL),] and EDCI (3.8 g, 19.8 [MMOL)] in DMF (20 mL). The solution is stirred for 3 hours at room temperature then diluted with EtOAc, washed with saturated [NAHCO3,] saturated NaCI, and dried (Na2SO4). The solvent is removed in vacuo and the residue obtained purified by HPLC to afford 1.7 g (40% yield) of the desired product NMR [(CDCI3)] 8 9.49-9. 46 (d, J=7.8 Hz, [1H),] 9.20-9. 18 (d, J=6.9 Hz, 1H), 8.52-8. 50 (d, J=5.5 Hz, [1H),] 7.86-7. 78 (m, 2H), 7.72-7. 63 (m, 2H), 5.79 (bs, [1H),] 5.55-5. 47 (m, [1H),] 4.76-4. 69 (d, d, [J=17.] 3,2. 3 Hz, [1H),] 4.45-4. 40 (d, [J=17.] 4 Hz, 1H), 4.25-4. 19 (d, [J=17.] 4 Hz, [1H),] 4.15-3. 98 (m, 3H), 3.73 (s, 3H), 3.65-3. 59 (d, [J=17.] 4 Hz, [1H),] 2.97-2. 90 (d, d, [J=18.] 2,3. 9 Hz, 1H), 2.48-2. 29 (m, 3H) [;’3C (CDCI3) S] 172.7, 170.5, 165.9, 148.2, 141.0, 137.7, 136.3, 130.7, 128.9, [127?7,] 127.2, 126.4, 124.7, 67.5, 60.8, 52.8, 50.3, 49.3, [48.] 1,32. 5,21. 4,14. 5; MS 384 (M+H) [+.]
The synthetic route of 486-73-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; THE PROCTER & GAMBLE COMPANY; WO2003/103677; (2003); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem