Tag: M.W=100-150

Dalai, Pallaba Ganjan published the artcileGeneration of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools for C-H Halogenation, Name: 1,3-Dimethoxybenzene, the main research area is arene DMSO coordinated halogen halogenation; haloarene preparation; alkene DMSO coordinated bromide halogenation; dibromoalkane preparation; diketone preparation; enamide DMSO coordinated bromide intramol cyclization; oxazole preparation.

A method to generate halogen cation pools from the reaction of 1,2-dihaloethanes (hal=Br, I) and DMSO (DMSO) for C-H halogenation of arenes and heteroarenes was reported. The initial reaction of DMSO and 1,2-dihaloethane generates the sulfur ylide, which undergoes pyrolytic elimination of ethylene by affording halonium ions. These ions were accumulated and stabilized by DMSO through coordination by forming halogen cation pools for the halogenation reaction. This protocol was selective for electrophilic monohalogenation of arenes at room temperature; however, polyhalogenated products were formed by raising the reaction temperature Late-stage halogenation of heteroarenes and some commonly marketed drugs signifies the synthetic utility of this protocol in pharmaceutical chem. Unlike the classical methods, the in-situ generated electrophilic bromonium ion was further exploited for the direct synthesis of α-diketones from the alkenes under base-free conditions.

Advanced Synthesis & Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mondal, Haripriyo published the artcileCooperativity within the catalyst: alkoxyamide as a catalyst for bromocyclization and bromination of (hetero)aromatics, SDS of cas: 151-10-0, the main research area is bromolactone aryl bromide chemoselective preparation; methoxybutanesulfonamide catalyst bromosuccinimide mediated bromocyclization bromination; chemoselective bromination bromocyclization methoxysulfonamide catalyst bromosuccinimide.

N-Methoxy-1-butanesulfonamide was a recyclable catalyst for the activation of N-bromosuccinimide to perform bromocyclization and bromination reactions of unsaturated carboxylic acids, alkenes and indoles with pendant nucleophiles, and arenes in heptane, where adequate suppression of the background reactions was observed, to yield bromolactones, bromomethyl-substituted heterocycles, fused indolines such as pyrroloindolines, and aryl bromides. The key feature of the active site is the alkoxy group attached to the sulfonamide moiety, which facilitates the acceptance as well as the delivery of bromonium species from the bromine source to the substrates.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Lei published the artcileRhenium-catalyzed alkylarylation of alkenes with PhI(O2CR)2via decarboxylation to access indolinones and dihydroquinolinones, Product Details of C8H11NO, the main research area is indolinone preparation regioselective; alkene hypervalent iodine compound cyclization rhenium catalyst; dihydroquinolinone preparation regioselective diastereoselective; cinnamamide hypervalent iodine compound cyclization rhenium catalyst.

Rhenium-catalyzed alkylarylation of alkenes RN(R1)C(O)C(=CH2)R2 (R = C6H5, 4-FC6H4, 2-CH3C6H4, etc.; R1 = CH3, CH2CH3, CH(CH3)2, C(O)CH3; R2 = Me, Ph) and 4-R3C6H4N(Me)C(O)CH=CHAr (R3 = Me, F, OMe, etc.; Ar = C6H5, 4-ClC6H4) with hypervalent iodine(III) reagents (HIRs) PhI(O2CR4)2 (R4 = Me, i-Pr, cyclopropyl, etc.) via decarboxylation to access various 3,3-disubstituted indolinones I (R5 = 5-F, 7-Me, 5-CN, etc.) and trans-3,4-dihydroquinolinones trans-II (R6 = Me, F, CF3, etc.) is described. These transformations feature wide substrate scopes, good functional-group tolerance, and divergent regioselectivity. Mechanistic studies revealed a cascade sequence of decarboxylation/intermol. radical alkylation/intramol. radical arylation/oxidative re-aromatization.

Organic Chemistry Frontiers published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Yuanyuan published the artcileChiral Selenide-Catalyzed, Highly Regio- and Enantioselective Intermolecular Thioarylation of Alkenes with Phenols, Application of 1,3-Dimethoxybenzene, the main research area is chiral phenol preparation regioselective enantioselective diastereoselective; alkene phenol thiosuccinimide three component thioarylation chiral selenide catalyst.

Enantioselective electrophilic three-component thioarylation of alkenes by chiral selenide catalysis with free phenols as arylating sources is disclosed. A variety of chiral phenols, e.g., I, were prepared in high regio-, enantio-, and diastereoselectivities. Mechanistic studies revealed that this transformation went through carbon nucleophilic attack to give the products rather than the process of intramol. rearrangement of phenolic ether intermediates. The application of this organocatalytic method in the alkylation of methoxy-substituted benzenes elucidated its generality.

ACS Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhu, Deng published the artcileN-Selenocyanato-Dibenzenesulfonimide: A New Electrophilic Selenocyanation Reagent, Category: isoquinoline, the main research area is selenocyanato dibenzenesulfonimide preparation selenocyanation nucleophile; tandem selenocyanation cyclization alkene phenol selenocyanato dibenzenesulfonimide reagent.

A new electrophilic selenocyanation reagent, N-selenocyanato-dibenzenesulfonimide, was readily prepared in two steps from com. available dibenzenesulfonimide for the first time. A variety of electrophilic selenocyanation reactions of nucleophiles have been achieved using this reagent as the selenocyanato source under mild and simple conditions. Numerous SeCN-containing compounds were obtained in moderate to excellent yields. Meanwhile, a Lewis acid-mediated tandem selenocyanation/cyclization reaction of alkenes with phenols, which provided simple methods for the formation of various SeCN-containing chromanes and dihydrobenzofurans in moderate to good yields, has also been developed.

Synthesis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sun, Li published the artcileElectrochemical Radical Selenylation of Alkenes and Arenes via Se-Se Bond Activation, Computed Properties of 151-10-0, the main research area is selenoether preparation regioselective; alkene activated arene electrochem radical selenylation.

A novel electrochem. radical selenylation of alkenes and activated arenes without external oxidants is reported. The diselenide was fully transformed into Se-centered radicals through electrochem. Se-Se bond activation. Three-component radical carbonselenation was successfully realized using styrenes to trap the RSe radical. Besides, the direct coupling of RSe radicals with activated arenes was further developed. Using this atom-economic protocol, diversity of unsym. aryl-aryl, aryl-alkyl, and alkyl-alkyl selenoethers was obtained regioselectively, which has potential application in biol. chem.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Yingmu published the artcileA mesoporous NNN-pincer-based metal-organic framework scaffold for the preparation of noble-metal-free catalysts, Product Details of C8H10O2, the main research area is zirconium terpyridinephenylcarboxylate MOF preparation gas adsorption isotherm epoxidation catalyst; borylation catalyst zirconium terpyridinephenylcarboxylate MOF; surface area pore size distribution thermal stability zirconium terpyridinephenylcarboxylate.

Through topol.-guided synthesis, a Zr-based mesoporous MOF was successfully constructed, adopting a β-cristobalite-type structure. The MOF is embedded with well-arranged terpyridine coordination sites for facile post-synthetic metalation, and can be effectively used as a general scaffold for the preparation of noble-metal-free catalysts. For instance, the scaffolded metal@MOF material exhibits highly efficient catalytic activity for alkene epoxidation and arene borylation.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ye, Ai-Hui published the artcileTMSCl-Catalyzed Electrophilic Thiocyano Oxyfunctionalization of Alkenes Using N-Thiocyano-dibenzenesulfonimide, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is chlorotrimethylsilane catalyzed electrophilic thiocyano oxyfunctionalization alkene; nitrogen thiocyano dibenzenesulfonimide electrophilic thiocyanation reagent.

Numerous electrophilic thiocyano oxyfunctionalization reactions of alkenes have been achieved using N-thiocyano-dibenzenesulfonimide, which is a new electrophilic thiocyanation reagent and could be easily prepared in two steps from dibenzenesulfonimide. This approach provides efficient, simple, and modular methods for the formation of SCN-containing heterocycles such as lactones, tetrahydrofurans, dihydrofurans, and dihydrobenzofurans in moderate to excellent yields. Meanwhile, diverse oxa-quaternary centers were rapidly constructed. Addnl., this protocol is free of transition metals and features broad substrate tolerance and mild reaction conditions.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Xin-Yu published the artcileSynthesis of Seleno Oxindoles via Electrochemical Cyclization of N-arylacrylamides with Diorganyl Diselenides, Name: 4-Methoxy-N-methylaniline, the main research area is selanylmethyl oxindole green preparation antitumor human; acrylamide diselenide electrochem tandem cyclization.

The tandem cyclization of acrylamides with diselenides facilitated by electrochem. oxidation was successfully developed. This strategy provided an environmentally friendly method for the construction of C-Se bond. A series of (arylselanylmethyl)oxindoles such as I [R1 = Me, Ph, 2-thienyl, etc.; R2 = H, 4-Me, 5-MeO, etc.; R3 = Me, Ph, Bn] with pharmacol. activity was obtained by using this well-designed tandem cyclization strategy. The in vitro antitumor activity of the compounds I [R1 = Ph; R2 = H; R3 = Me, Bn] was also screened through MTT assay. Results showed that the (arylselanylmethyl)oxindoles I [R1 = Ph; R2 = H; R3 = Me, Bn] exhibited better antitumor activity than other oxindole derivatives II [R = CF3, PhSO2].

Advanced Synthesis & Catalysis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Name: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kim, Yerin published the artcileEfficient Synthesis of Diarylmethylamines via Lewis Acid Catalyzed Friedel-Crafts Reactions of Donor-Acceptor Aziridines with N, N-Dialkylanilines, Category: isoquinoline, the main research area is diarylmethylamine scaffold preparation chemoselective; aziridine dialkylaniline Friedel Crafts Lewis acid catalyst.

A method for efficient and mild synthesis of diarylmethylamine scaffolds I [R1 = Ph, 1-naphthyl, 4-ClC6H4, etc.; R2 = Me, Et, Bn, etc.; R3 = 4-NMe2C6H4, 2-Me-4-NMe2C6H3, 1-pyrrolidyl, etc.] via Lewis acid catalyzed Friedel-Crafts reaction of donor-acceptor aziridines with N, N-dialkylanilines in high yields (up to 88%) was reported. This reaction was suitable for the synthesis of various compounds I and had a broad scope for electron-rich arenes, including dimethoxybenzene.

Synthesis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem