Tag: M.W=100-150

Lenci, Elena published the artcileA Glucose-Derived α-Hydroxy Aldehyde for the Petasis Reaction: Facile Access to Polyfunctional δ-Amino Acids, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is glucose hydroxy aldehyde preparation multicomponent Petasis borono Mannich; polyfunctional amino acid preparation multicomponent Petasis borono Mannich.

The multicomponent Petasis borono-Mannich reaction proceeds via an imine with the boronic acid acting as the nucleophile for the preparation of amines and their derivatives, including amino acids. In view of the expansion of the poorly-exploited carbohydrate chem. using this reaction, a new α-hydroxy aldehyde moiety from the terminal diol of D-glucose diacetonide was synthesized and applied to this multicomponent reaction, demonstrating the scope of this method and the applicability to the convenient preparation of a protected polyfunctional δ-amino acid in only three synthetic steps from the Petasis reaction intermediate.

European Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Onida, Killian published the artcileDirect Synthesis of Carbamoyl Fluorides by CO2 Deoxyfluorination, Synthetic Route of 5961-59-1, the main research area is carbamoyl fluoride synthesis carbon dioxide deoxyfluorination amine DAST; amines; carbamoyl fluorides; carbon dioxide; deoxyfluorination; fluorine.

Herein, a new concept for the direct synthesis of carbamoyl fluoride derivatives is disclosed. The developed method makes use of CO2 as an inexpensive and abundant C1 source; a variety of amines were successfully converted in the presence of a deoxyfluorinating reagent. The corresponding products were often obtained in excellent yields under mild reaction conditions (1 atm and room temperature). The reaction was easily scaled up, demonstrating the efficiency of the developed process.

Angewandte Chemie, International Edition published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Saadati, Fariba published the artcileGuanidinate Early-Transition-Metal Complexes: Efficient and Selective Hydroaminoalkylation of Alkenes, SDS of cas: 5961-59-1, the main research area is tantalum methylamido silylmethyl complex catalyst hydroaminoalkylation alkene; crystal structure methylamido silylmethyl triazabicyclodecene tantalum complex; mol structure methylamido silylmethyl triazabicyclodecene tantalum complex.

The influence of N,N-chelating guanidinate ligands on the reactivity of in situ generated Ta complexes for the intermol. hydroaminoalkylation of amines were explored. Increased conversion was observed with the Na salt of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBDNa) paired with the Ta precursor Ta(CH2SiMe3)3Cl2 at 110°. Terminal alkenes underwent hydroaminoalkylation with a variety of secondary amine substrates to give substituted secondary amine products. Mono- and bis(guanidinate) Ta complexes were prepared, and their structures were studied. Importantly, the guanidinate ligand could be alkylated in the β position using Ta(NMe2)5 as a precatalyst to give the linear regioisomer as the major product, and this substituted ligand gave improved hydroaminoalkylation conversion in comparison to the parent ligand.

Organometallics published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, SDS of cas: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ouyang, Wensen published the artcileModular construction of functionalized anilines via switchable C-H and N-alkylations of traceless N-nitroso anilines with olefins, Related Products of isoquinoline, the main research area is functionalized aniline preparation chemoselective regioselective; nitroso aniline olefin alkylation rhodium catalyst.

A switchable C-H alkylation and N-alkylation with great chemo- and site-selectivity enabled by N-nitroso anilines was developed, affording functionalized anilines, hydrazines and heterocycles. The exploration of strain-release as the key driving force with structurally diverse olefins enabled mild and practical sequential C-H and C-C or C-O cleavage. Notably, N-nitroso anilines could act as traceless directing groups to enable indole synthesis via dehydrogenative coupling with styrenes.

Organic Chemistry Frontiers published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yang, Ji published the artcileA Selective and General Cobalt-Catalyzed Hydroaminomethylation of Olefins to Amines, HPLC of Formula: 5961-59-1, the main research area is selective cobalt catalyst hydroaminomethylation olefin amine; amines; carbonylation; catalysis; cobalt; ligand design.

A new cobalt catalyst is presented for the domino hydroformylation-reductive amination reaction of olefins. The optimal Co-tert-BuPy-Xantphos catalyst shows good to excellent linear-to-branched (n/iso) regioselectivity for the reactions of aliphatic alkenes with aromatic amines under mild conditions. This system is far more selective than traditional cobalt(I) catalysts and even better than most known rhodium catalysts.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kaper, Tobias published the artcileHydroaminoalkylation/Buchwald-Hartwig amination sequences for the synthesis of benzo-annulated seven-membered nitrogen heterocycles, Computed Properties of 5961-59-1, the main research area is alkene bromophenyl amine titanium hydroaminoalkylation catalyst; aminoalkyl bromobenzene preparation palladium Buchwald Hartwig amination catalyst; azepane preparation.

Reaction sequences consisting of an initial intermol. titanium-catalyzed hydroaminoalkylation of a suitably ortho-bromophenyl-substituted alkene and a subsequent intramol. Buchwald-Hartwig amination are used for the synthesis of benzazepine, benzoxazepine, and benzothiazepine derivatives While in the latter two cases, the hydroaminoalkylation products obtained from an allyl (2-bromophenyl) ether or an allyl (2-bromophenyl) thioether must be purified prior to the subsequent palladium-catalyzed amination step, both reactions can be combined to an efficient one-pot procedure for the synthesis of 2,3,4,5-tetrahydrobenzo[b]azepines when 4-(2-bromophenyl)-1-butene and various N-methylanilines are used as the starting materials.

Tetrahedron published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Manssen, Manfred published the artcileUreate Titanium Catalysts for Hydroaminoalkylation: Using Ligand Design to Increase Reactivity and Utility, COA of Formula: C8H11NO, the main research area is methylamine alkene ureate titanium catalyst regioselective hydroaminoalkylation green chem; alkylamine prepb.

Herein, an earth-abundant and cost-efficient titanium catalyst generated in situ using com. available Ti(NMe2)4 and a simple to synthesize urea proligand was described. This system demonstrated high TOFs for hydroaminoalkylation with unactivated substrates and features easy to use com. available titanium amido precursors. Addnl., a high catalytic activity, scope of reactivity, and regioselectivity were all demonstrated in the transformation of unactivated terminal olefins with various alkyl and aryl secondary amines. Finally, syntheses of useful amine-containing monomers suitable for the generation of amine-containing materials, as well as amine-containing building blocks for medicinal chem., were disclosed. These preparative methods avoid the necessity of glovebox techniques and were modified to be useful to all synthetic chemists.

ACS Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bielefeld, Jens published the artcileFast Titanium-Catalyzed Hydroaminomethylation of Alkenes and the Formal Conversion of Methylamine, Category: isoquinoline, the main research area is alkene hydroaminomethylation titanium catalyst methylamine conversion; amines; hydroaminoalkylation; methylamine; phenethylamine; titanium.

The scientific interest in catalytic hydroaminoalkylation reactions of alkenes has vastly increased over the past decade, but these reactions have struggled to become a viable option for general laboratory or industrial use because of reaction times of several days. The titanium-based catalytic system introduced in this work not only reduces the reaction time by several orders of magnitude, into the range of minutes, but the catalyst also is easily available from common starting materials, at a cost of � euro per mmol of catalyst. The authors were also able to formally perform C-H activation of methylamine and achieve coupling to a broad variety of alkenes, through silyl protection of the amine and simple deprotection by water.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

He, Jing-Yao published the artcilePhotoredox One-Pot Synthesis of 3,4-Dihydroquinolin-2(1H)-ones, Name: 4-Methoxy-N-methylaniline, the main research area is dihydroquinolione preparation; alkene arylamine oxalyl chloride heterocyclization photoredox reaction iridium catalyst.

A photoredox one-pot strategy for efficient accessing 3,4-dihydroquinolin-2(1H)-ones I [R1 = H, Me, OMe, Cl; R2 = Me, Bn, allyl; R3 = H, Me; R4 = C(O)OEt, C(O)Et, S(O)2Ph, etc.; R3R4 = -CH2CH2OC(O)-] from anilines 4-R1C6H4NHR2, oxalyl chloride, and electron-deficient alkenes R3C(=CH2)R4 is disclosed. The new approach features excellent synthetic efficiency, readily available starting materials, and simple operations. It is compatible with a variety of anilines and electron-deficient alkenes. A broad array of 3,4-dihydroquinolin-2(1H)-ones I was prepared

Synlett published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Name: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chen, Bi-Hong published the artcileOrganophotocatalytic Regioselective C-H Alkylation of Electron-Rich Arenes Using Activated and Unactivated Alkenes, Application of 1,3-Dimethoxybenzene, the main research area is heteroarene activated unactivated alkene carbon hydrogen alkylation regioselective organophotocatalyst; Alkenes; C−H Alkylation; Photocatalysis; Reaction Mechanisms; Regioselectivity.

Direct alkylation of the C-H bond arenes in a selective manner is a long-standing challenge. Herein, a metal-free photocatalytic regioselective C-H alkylation method for electron-rich arenes with both activated and unactivated alkenes was developed. The reaction tolerates a wide range of aromatic rings with diverse substitution patterns, as well as terminal and internal alkenes, providing a general and straightforward metal-free method for C-C bond formation from inert C-H bonds. Moreover, alkynes are also compatible to give the C-H vinylation of electron-rich arenes.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem