Tag: M.W=100-150

Xu, Zhuo-Wei published the artcileAn efficient method for the N-formylation of amines under catalyst- and additive-free conditions, Quality Control of 5961-59-1, the main research area is amine ethyl bromodifluoroacetate green formylation; formamide preparation.

A simple catalyst- and additive-free method for the N-formylation of amines has been developed. The advantages of this protocol include a wide range of functional group tolerance, high efficiency and a lack of required extra promoters under mild conditions. This convenient strategy will provide a facile synthesis towards N-formamide natural products and pharmaceutical derivatives A mechanism that involves difluorocarbene is proposed for this reaction.

Tetrahedron Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wei, Xiu-Zhi published the artcileTriethylamine Catalyzed Reductive CO2 to Form N-Formylation of Amines and Hydrazides, COA of Formula: C8H11NO, the main research area is formamide formyl hydrazide preparation; amine hydrazide carbon dioxide formylation triethylamine.

Carbon dioxide was one of the main green-house gas, using CO2 as a C1 source to produce functional chems. can relieve environmental issues. With the development of the N-formylation reaction of amines under a CO2 atmosphere, a promising route for the synthesis of diacylhydrazines is the N-formylation of hydrazide with CO2 in the presence of a reducing agent. Triethylamine (TEA) is an organic base commonly used in organic synthesis, which has a low b.p. to easily separated from the system by decompression distillation Authors herein describe TEA-catalyzed selective N-formylation of amines/hydrazide using CO2 and NaBH4 to construct various formamide and N’-formyl-hydrazide. Utilizing N-formylation of amines reaction to tune the reaction solvent, base, and temperature given a lower boiling catalyst and solvent system and the product can be separated easily. The selective synthesis method of formamides is achieved in good yields, which is also equally adapted to hydrazides. Finally, 1,3,4-oxadiazole skeleton having synthetic drugs and material application was obtained by cyclization of N’-formyl-hydrazide.

ChemistrySelect published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Cheng, Lin-Chieh published the artcileSynthesis of Quinolinium Salts from N-Substituted Anilines, Aldehydes, Alkynes, and Acids: Theoretical Understanding of the Mechanism and Regioselectivity, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is aniline aldehyde alkyne acid multicomponent regioselective coupling mechanism DFT; quinolinium salt preparation.

Secondary anilines were first utilized in the four-component coupling of aniline, aldehyde, alkyne, and acid to synthesize a variety of N-substituted quinolinium salts, e.g., I. This method was carried out under mild reaction conditions and exhibited excellent chemo- and regioselectivities. DFT calculation was performed to analyze the cyclization step, where the interaction/distortion model provided better insight into the singular selectivity of terminal/internal alkynes in reaction.

European Journal of Organic Chemistry published new progress about Acids Role: RGT (Reagent), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Duan, Peng published the artcileConstruction of Fluorinated Amino Acid Derivatives via Cobalt-Catalyzed Oxidative Difunctionalization of Cyclic Ethers, Quality Control of 5961-59-1, the main research area is trifluoromethyl amino acid ester preparation diastereoselective; amine cyclic ether ethyl trifluoropyruvate oxidative difunctionalization cobalt catalyst.

A new synthetic method for the efficient construction of novel fluorinated γ-amino acid esters I (n = 1, 2; R = H, Me; R1 = methyl(phenyl)aminyl, 1,2,3,4-tetrahydroquinolin-1-yl, 1H,2H,3H-pyrrolo[2,3-b]pyridin-1-yl, etc.) via difunctionalization of the α- and β-sites of cyclic ethers such as THF, tetrahydropyran, 2-methyloxolane and 2,3-dihydrofuran, by employing a CoBr2/m-CPBA catalyst system was demonstrated. Several cyclic ethers were transformed in combination with a vast range of amines such as 4-methylaniline, thiomorpholine, tetrahydroquinoline, etc. and Et trifluoropyruvate into the desired products I under mild conditions, making this method a practical platform to enrich the library of fluorinated amino acid derivatives from cost-effective and readily available feedstocks.

Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Adusumalli, Krishna M. S. published the artcileMe3Al-mediated domino nucleophilic addition/intramolecular cyclisation of 2-(2-oxo-2-phenylethyl)benzonitriles with amines: A convenient approach for the synthesis of substituted 1-aminoisoquinolines, Application of 4-Methoxy-N-methylaniline, the main research area is aminoisoquinoline preparation trimethylaluminum reagent; benzonitrile amine tandem nucleophilic addition intramol cyclization trimethylaluminum; 1-aminoisoquinolines; 2-(2-oxo-2-phenylethyl)benzonitriles; CWJ-a-5; intramolecular cyclisation; nucleophilic addition.

A simple and efficient protocol for the construction of 1-aminoisoquinolines was achieved by treating 2-(2-oxo-2-phenylethyl)benzonitriles with amines in the presence of Me3Al. The reaction proceeds via a domino nucleophilic addition with subsequent intramol. cyclization. This method provides a wide variety of substituted 1-aminoisoquinolines with good functional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated in the successful synthesis of the antitumor agent CWJ-a-5, I, on a gram scale.

Beilstein Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Gonzalez-Lainez, Miguel published the artcileN-Methylation of Amines with Methanol Catalyzed by Iridium(I) Complexes Bearing an N,O-Functionalized NHC Ligand, Category: isoquinoline, the main research area is iridium complex imidazolylidenelutidine polydentate ligand preparation catalyst methylation aniline; crystal structure iridium complex containing imidazolylidenelutidine polydentate ligand; mol structure iridium complex containing imidazolylidenelutidine polydentate ligand.

A set of neutral [IrBr(L2)(κC-tBuImCH2PyCH2OMe)] and cationic [Ir(L2)(κ2C,N-tBuImCH2PyCH2OMe)]PF6 (L2 = cod, (CO)2) Ir(I) compounds featuring a flexible lutidine-derived polydentate ligand having NHC and -OMe as donor functions were evaluated as catalyst precursors for the N-methylation of aniline using MeOH both as a reducing agent and a C1 source. The carbonyl complexes are somewhat more active than the related diene compounds with the neutral compound [IrBr(CO)2(κC-tBuImCH2PyCH2OMe)] being the more active. A range of aromatic primary amines, including heterocyclic amines, were selectively transformed into the corresponding N-methylamino derivatives using this catalyst at a low catalyst loading (0.1 mol %) and substoichiometric amounts of Cs2CO3 (half equiv) as a base, in MeOH at 423 K. For aliphatic primary amines, selective N,N-dimethylation was achieved under the same catalytic conditions. The unselective deprotonation of the methylene linkers in [IrBr(CO)2(κC-tBuImCH2PyCH2OMe)] affords two isomeric neutral complexes featuring a coordinated dearomatized pyridine core, which were converted into [Ir(OMe)(CO)2(κC-tBuImCH2PyCH2OMe)] upon addition of MeOH. This compound undergoes thermal activation of a C-H bond of the tert-Bu group to give the cyclometalated Ir(I) complex [Ir(CO)2{κ2C,C-(-CH2Me2C-ImCH2PyCH2OMe)}] featuring a bidentate C,C-coordinated NHC ligand. Mechanistic studies support a borrowing H mechanism proceeding through Ir(I) intermediates with the methoxo complex as the catalytic active species and the cyclometalated complex as the catalyst resting state. D labeling experiments demonstrated that both species are in equilibrium under catalytic conditions, which is consistent with the exhibited catalytic activity of the cyclometalated complex.

Organometallics published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Kangkang published the artcileInvestigation of NNN Pincer Ruthenium(II) Complexes with a Pendant Hydroxyl Group for N-Monomethylation of amines and Nitroarenes by Methanol, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is hydroxy trinitrogen NNN pincer ruthenium preparation crystal mol structure; monomethylation amine nitroarene methanol hydroxy trinitrogen pincer ruthenium catalyzed.

A family of air- and moisture-stable NNN pincer ruthenium(II) complexes with a pendant OH were developed, which exhibit unprecedented high reactivity and selectivity in N-monomethylation of amines and nitroarenes using methanol. The study reveals adopting the combination of 1H-pyrazole-1-yl and 3,5-dimethyl-4-hydroxyethyl-1H-pyrazol-1-yl as the two assistant arms of the pyridyl-backbone is a suitable choice. The mechanism study discloses that, during the catalytic cycle, dehydrogenation of methanol to form formaldehyde is a fast and reversible step.

ChemCatChem published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chen, Xiu-Ping published the artcileStudy on the mild, rapid and selective difluorocarbene-mediated triclassification of iododifluoroacetophenone with secondary amines and tree model for product classification, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is difluoromethyl benzoimidazole preparation; indole difluoromethyl preparation; formamide aryl preparation; benzothiazole difluoromethyl thio preparation; benzooxazole difluoromethyl thio preparation; aryl difluoromethoxy preparation.

In this work, a room temperature difluorocarbene-mediated triclassification reaction of iododifluoroacetophenone and secondary amines with mild condition, short reaction time (only 10 min) and high selectivity had been studied, which produced one of the following three substances: N-CF2H derivatives I [R1 = H, SCF2H, 2-pyridyl, (3,4-dichlorophenyl)methyl; R2 = H, CN, C(O)Me, (2-chloropyrimidin-4-yl); R3 = H, 5-Br, 6-NO2, 5,6-di-Me, 6-Me-5-NO2; X = C, N; Y = C, N] (up to 87% yield), formamides ArNR4C(O)H [Ar = Ph, 4-MeOC6H4, 1-naphthyl; R4 = Me, Et] (82-89% yield) or the recycled starting secondary amines. This phenomenon was related to the structural stability of the corresponding products. If unstable, it would be hydrolyzed to formamides first, and then further hydrolyzed to starting amines. Based on the geometric structure of the raw materials, the corresponding prediction tree model was established, which provided guidance for the further application of difluoromethylation of Vemurafenib and AZD9291. In addition, this method was successfully applied to the S- and O-difluoromethylations to obtain the corresponding sulfur derivatives II [Z = S, O; R5 = 5-Cl, 6-Br, 4-Me, etc.] and O-CF2H derivatives ArO-CF2H [Ar = 3,4-di-MeOC6H3 1-naphthyl, 4-PhC6H4, etc.] with satisfactory yields.

Tetrahedron published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yu, Haitao published the artcileDihydrolevoglucosenone as a bio-based catalytic solvent for efficient reductive-transformation of CO2 with amines into formamides and benzothiazoles, Category: isoquinoline, the main research area is formamide benzothiazole preparation; carbon dioxide amine reductive transformation dihydrolevoglucosenone bio catalytic solvent.

Transformation of CO2 as the C1 resource to produce value-added chems. is of great importance to decrease CO2 emission. In this context, development of green catalytic systems, especially those derived from renewable resources, is highly attractive to make the processes of converting CO2 more sustainable, which has gained significant interest. In this work, cellulose-derived dihydrolevoglucosenone (DLGO, Cyrene) was employed as a renewable catalytic solvent to convert CO2. DLGO was highly efficient for reductive conversion of CO2 with amines using PhSiH3 as the reductant, and various corresponding formamides could be selectively synthesized. Reaction kinetics anal. suggested that DLGO-based catalytic system possessed a higher reaction rate constant and lower apparent activation energy than both GVL and CH3CN-based catalytic systems. Furthermore, systematic studies revealed that DLGO with high polarity had strong ability to activate the N-H bond in amines and the Si-H bond in PhSiH3 by the solvent effect (i.e., solvation and polarization), thereby making the catalytic system be highly efficient. This developed biomass-based catalytic system could be expanded to synthesize benzothiazoles from the reductive conversion of CO2 with aminothiophenols using PhSiH3 as the reductant. Notably, the DLGO-based system combined CO2 transformation and biomass utilization, affording it possessing more values of practical applications.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tang, Feiying published the artcileBiomass-derived N-doped porous carbon: an efficient metal-free catalyst for methylation of amines with CO2, SDS of cas: 5961-59-1, the main research area is biomass derived nitrogen doped carbon catalytic methylation amine.

Developing green, efficient, and low-cost catalysts for methylation of N-H by using CO2 as the C1 resource is highly desired yet remains a significant challenge. Herein, N-doped porous carbons (NPCs) were designed, synthesized, and are an excellent metal-free catalyst for CO2-participated methylation conversion. NPCs were prepared via the pyrolysis of a mixture of tannic acid and urea. Both theor. calculation and the N species especially pyridinic N and pyrrolic N within NPCs can work as Lewis basic sites for attacking CO2 to weaken the C=O bonds and lower the mol. conversion barrier, facilitating the subsequent methylation of N-H to produce, for example, N,N-dimethylaniline. Besides, the unique porous structure can enrich CO2 and accelerate mass transfer, synergistically promoting the conversion of CO2. The optimized NPC(1/5) catalyst, integrating the porous structure and strong Lewis basicity, exhibits excellent catalytic activity for CO2-based methylation reaction under mild conditions (1 bar CO2, 75°). The work, for the 1st time, demonstrates the feasibility of using NPCs to catalyze the methylation of amino compounds to produce N,N-dimethylamine by exploiting CO2 as the C1 resource.

Green Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, SDS of cas: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem