Wei, Xiu-Zhi published the artcileTriethylamine Catalyzed Reductive CO2 to Form N-Formylation of Amines and Hydrazides, COA of Formula: C8H11NO, the main research area is formamide formyl hydrazide preparation; amine hydrazide carbon dioxide formylation triethylamine.
Carbon dioxide was one of the main green-house gas, using CO2 as a C1 source to produce functional chems. can relieve environmental issues. With the development of the N-formylation reaction of amines under a CO2 atmosphere, a promising route for the synthesis of diacylhydrazines is the N-formylation of hydrazide with CO2 in the presence of a reducing agent. Triethylamine (TEA) is an organic base commonly used in organic synthesis, which has a low b.p. to easily separated from the system by decompression distillation Authors herein describe TEA-catalyzed selective N-formylation of amines/hydrazide using CO2 and NaBH4 to construct various formamide and N’-formyl-hydrazide. Utilizing N-formylation of amines reaction to tune the reaction solvent, base, and temperature given a lower boiling catalyst and solvent system and the product can be separated easily. The selective synthesis method of formamides is achieved in good yields, which is also equally adapted to hydrazides. Finally, 1,3,4-oxadiazole skeleton having synthetic drugs and material application was obtained by cyclization of N’-formyl-hydrazide.
ChemistrySelect published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem