Adusumalli, Krishna M. S. published the artcileMe3Al-mediated domino nucleophilic addition/intramolecular cyclisation of 2-(2-oxo-2-phenylethyl)benzonitriles with amines: A convenient approach for the synthesis of substituted 1-aminoisoquinolines, Application of 4-Methoxy-N-methylaniline, the main research area is aminoisoquinoline preparation trimethylaluminum reagent; benzonitrile amine tandem nucleophilic addition intramol cyclization trimethylaluminum; 1-aminoisoquinolines; 2-(2-oxo-2-phenylethyl)benzonitriles; CWJ-a-5; intramolecular cyclisation; nucleophilic addition.
A simple and efficient protocol for the construction of 1-aminoisoquinolines was achieved by treating 2-(2-oxo-2-phenylethyl)benzonitriles with amines in the presence of Me3Al. The reaction proceeds via a domino nucleophilic addition with subsequent intramol. cyclization. This method provides a wide variety of substituted 1-aminoisoquinolines with good functional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated in the successful synthesis of the antitumor agent CWJ-a-5, I, on a gram scale.
Beilstein Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem