Duan, Peng published the artcileConstruction of Fluorinated Amino Acid Derivatives via Cobalt-Catalyzed Oxidative Difunctionalization of Cyclic Ethers, Quality Control of 5961-59-1, the main research area is trifluoromethyl amino acid ester preparation diastereoselective; amine cyclic ether ethyl trifluoropyruvate oxidative difunctionalization cobalt catalyst.
A new synthetic method for the efficient construction of novel fluorinated γ-amino acid esters I (n = 1, 2; R = H, Me; R1 = methyl(phenyl)aminyl, 1,2,3,4-tetrahydroquinolin-1-yl, 1H,2H,3H-pyrrolo[2,3-b]pyridin-1-yl, etc.) via difunctionalization of the α- and β-sites of cyclic ethers such as THF, tetrahydropyran, 2-methyloxolane and 2,3-dihydrofuran, by employing a CoBr2/m-CPBA catalyst system was demonstrated. Several cyclic ethers were transformed in combination with a vast range of amines such as 4-methylaniline, thiomorpholine, tetrahydroquinoline, etc. and Et trifluoropyruvate into the desired products I under mild conditions, making this method a practical platform to enrich the library of fluorinated amino acid derivatives from cost-effective and readily available feedstocks.
Organic Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem