Tag: M.W=100-150

Knighton, Richard C. published the artcileSynthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1′-Biphenyl-2,2′,6,6′-tetrol, Application of 1,3-Dimethoxybenzene, the main research area is biphenyltetrol alkyne preparation; azide alkyne cycloaddition biphenyltetrol alkyne; peptide stapling biphenyltetrol alkyne.

The novel ‘double strained alkyne’ I has been prepared and evaluated in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with azides. The X-ray crystallog. structure of I, which was prepared in one step from 1,1′-biphenyl-2,2′,6,6′-tetrol, reveals the strained nature of the alkynes. Dialkyne I undergoes cycloaddition reactions with a number of azides, giving mixtures of regioisomeric products in excellent yields. The monoaddn. products were not observed or isolated from the reactions, suggesting that the second cycloaddition proceeds at a faster rate than the first, and this is supported by mol. modeling studies. Dialkyne I was successfully employed for ‘peptide stapling’ of a p53-based diazido peptide, whereby two azides are bridged to give a product with a stabilized conformation.

ACS Omega published new progress about Azide-alkyne 1,3-dipolar cycloaddition reaction. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ding, Yuxin published the artcileEnvironmentally Benign Synthesis of Quinoline-Spiroquinazolinones by Iron-Catalyzed Dehydrogenative [4 + 2] Cycloaddition of Secondary/Tertiary Anilines and 4-Methylene-quinazolinones, Category: isoquinoline, the main research area is quinoline spiroquinazolinone green preparation; aniline methylene quinazolinone dehydrogenative cycloaddition iron catalyst.

An efficient iron-catalyzed cross-dehydrogenative coupling [4 + 2] annulation of secondary/tertiary anilines with quinazolinones to generate quinoline-spiroquinzolinones I [R1 = H, 7-Me; R2 = n-Pr, 3-ClC6H4, Bn, etc.; R3 = H, 6-Br, 7-Me, etc.; X = O, S] was reported. The reaction proceeded smoothly with a relatively broad variety of functional groups, a cheap transition metal catalyst (FeCl3), and environmentally friendly oxidant (H2O2/O2) under mild reaction conditions. Creatively, N-methylanilines were employed for the first time for the cycloaddition as both Me and methylene sources attached to the N atom of tetrahydroquinolines.

Journal of Organic Chemistry published new progress about [4+2] Cycloaddition reaction (dehydrogenative). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Takaishi, Kazuto published the artcileUnexpected Macrocyclic Multinuclear Zinc and Nickel Complexes that Function as Multitasking Catalysts for CO2 Fixations, Safety of 4-Methoxy-N-methylaniline, the main research area is epoxide carbon dioxide fixation binaphthyl bipyridyl zinc nickel catalyst; cyclic carbonate preparation; amine hydrosilane zinc nickel catalyst formylation methylation chemoselective DFT; tertiary amine preparation; N-functionalization; carbon dioxide fixation; cyclic carbonates; multinuclear complexes; self-assembly.

Unique self-assembled macrocyclic multinuclear ZnII and NiII complexes with binaphthyl-bipyridyl ligands (L) were synthesized. X-ray anal. revealed that these complexes consisted of an outer ring (Zn3L3 or Ni3L3) and an inner core (Zn2 or Ni). In the ZnII complex, the inner Zn2 part rotated rapidly inside the outer ring in solution on an NMR timescale. These complexes exhibited dual catalytic activities for CO2 fixations: synthesis of cyclic carbonates from epoxides and CO2 and temperature-switched N-formylation/N-methylation of amines with CO2 and hydrosilane.

Angewandte Chemie, International Edition published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mamidala, Ramesh published the artcilePalladacycle-Phosphine Catalyzed Methylation of Amines and Ketones Using Methanol, Product Details of C8H11NO, the main research area is amine ketone methylation palladacycle phosphine catalyst methanol.

Methylation of amines and ketones with palladacycle precatalyst was performed using methanol as an environmentally benign reagent. Various ketones and amines undergo methylation reaction to yield monomethylated amines or ketones in moderate to good isolated yields. Moreover, this protocol was tested for the chemoselective methylation of 4-aminobenzenesulfonamide. The scope of the reaction was further extended to the deuteromethylation of ketones.

Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Shihaozhi published the artcileCopper-Catalyzed Cascade N-Dealkylation/N-Methyl Oxidation of Aromatic Amines by Using TEMPO and Oxygen as Oxidants, Application of 4-Methoxy-N-methylaniline, the main research area is aryl formamide preparation; amine aryl cascade dealkylation oxidation catalyst copper.

A novel tandem N-dealkylation and N-Me aerobic oxidation of tertiary aromatic amines to N-arylformamides ArNC(O)H [Ar = Ph, 4-MeC6H4, 3-MeOC6H4, etc.] using copper and TEMPO was developed. This methodol. suggested an alternative synthetic route from N-methylarylamines to N-arylformamides ArNC(O)H.

European Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Xuehao published the artcileThree-component reaction access to S-alkyl dithiocarbamates under visible-light irradiation conditions in water, Application In Synthesis of 5961-59-1, the main research area is triphenyl pyridinium tetrafluoroborate carbon disulfide amine deamination three component; alkyl dithiocarbamate preparation green chem.

An efficient and environmentally friendly visible-light promoted method for the synthesis of S-alkyl dithiocarbamates with a broad substrate scope and good functional group tolerance in water was developed. Most appealingly, the reaction was proceeded smoothly without any external photocatalyst was added. This method opens a new avenue towards S-alkyl dithiocarbamates, thus promising their broad applications in pharmaceutical chem. and sulfur chem.

Green Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application In Synthesis of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Leung, Gulice Yiu Chung published the artcileEfficient and Practical Synthesis of Sulfonamides Utilizing SO2 Gas Generated On Demand, HPLC of Formula: 151-10-0, the main research area is sulfonamide preparation continuous flow; amine organometallic compound demetalation.

A simple and practical protocol was developed for the synthesis of sulfonamides RSO2R1 (R = Ph, 4-fluorophenyl, 2-benzofuranyl, etc; R1 = NH2, NHMe, morpholin-4-yl, benzyl, cyclopropyl, etc.) by reacting organometallic reagents RM (M = MgBr, Li) with SO2 gas generated on demand. SO2 was generated from readily available reagents safely in a highly contained and controlled fashion. The protocol allows the synthesis of sulfonamides without using either atom-inefficient SO2 surrogates or a SO2 cylinder that requires stringent storage regulations in the laboratory The protocol was successfully applied to the synthesis of sildenafil.

Organic Process Research & Development published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Schaub, Stefan published the artcileA Facile and Inexpensive Way to Synthesize N-trifluoromethyl Compounds, Application of 1,3-Dimethoxybenzene, the main research area is secondary amine trifluoromethylation; trifluoromethyl tertiary amine preparation.

A facile way to introduce CF3 groups on a large variety of secondary amines was developed by avoiding expensive and hazardous reagents. The advantage of the method could be demonstrated by obtaining crystalline tert-Bu 4-(trifluoromethyl)piperazine-1-carboxylate, a compound that previously was obtained as an oil. A major problem was the extreme sensitivity of these compounds toward moisture.

ChemistrySelect published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Jixiao published the artcileUnsupported Nanoporous Palladium Catalyst for N-Formylation of Amines Using CO2 as a Sustainable C1 Source, COA of Formula: C8H11NO, the main research area is formamide green preparation; amine carbon dioxide formylation nanoporous palladium catalyst.

An efficient heterogeneous catalytic system for the synthesis of aryl formamides R1N(C(O)H)R2 [R1 = Ph, 4-MeC6H4, 2-MeOC6H4, etc.; R2 = H, Me, Bn, etc.; R1 = R2 = Ph, Bn, Cy, etc.] via N-formylation of amines using CO2 as a sustainable C1 source was developed using unsupported nanoporous palladium (PdNPore). The PdNPore-catalyzed N-formylation of amines and CO2 with hydrosilane proceeded smoothly under mild reaction conditions to yield formamides in satisfactory to excellent yields. No palladium leached from PdNPore during the hydrogenation reaction. Moreover, the catalyst was easily recovered and reused without any loss of catalytic activity. This study was the first to demonstrate that PdNPore catalyzed CO2 conversion to form C-N bond, which enriches the reaction types of CO2 conversion catalyzed by PdNPore catalyst.

Asian Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Du, Chongyang published the artcileZinc Powder Catalysed Formylation and Urealation of Amines Using CO2 as a C1 Building Block, Category: isoquinoline, the main research area is formamide preparation; secondary amine carbon dioxide formylation zinc catalyst; urea preparation; primary amine carbon dioxide urealation zinc catalyst.

The zinc powder catalyzed formylation and urealation of secondary amines e.g., N-methylaniline and primary aromatic amines RNH2 (R = Ph, 2,4,6-trimethylphenyl, cyclohexyl, etc.) with CO2 and (EtO)3SiH under solvent-free condition were reported. Using 2 mol% zinc powder as the catalyst, a series of secondary amines, both the aromatic ones and the aliphatic ones can be formylated into formamides e.g., N-methyl-N-phenylformamide. When primary aromatic amines were used as the substrates, the reactions produce urea derivatives RNHC(O)NHR. The electronic and steric effects from the substrates on the formylation and urealation reactions were observed and discussed. The recovery and reusability of zinc powder were investigated, showing that zinc powder can be reused in the formylation reaction without loss of catalytic activity. The anal. on the reactants/products mixture after filtering out the zinc powder showed that zinc concentration in the mixture is low to 1 ppm. The pathways for the formylation and urealation of amines with this catalytic system were also investigated and related to the different substrates.

Chinese Journal of Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem