Tag: M.W=100-150

Matsukawa, Yuta published the artcileReactions between 5-Nitroso-1,3-diphenyltetrazolium Salts and Electron-Rich Arenes, Amines, Thiophenol, Sulfoxides, and Thioanisole, Product Details of C8H10O2, the main research area is nitroso diphenyltetrazolium salt arene amine thiophenol sulfoxide thioanisole oxidation.

A series of reactions between 5-nitroso-1,3-diphenyltetrazolium tetrafluoroborate and methoxybenzenes such as 1,3,5-trimethoxybenzene, 1,3-dimethoxybenzene, methoxybenzene, amines such as aniline, N,N’-bianiline, benzhydrylamine, benzylamine, thiols (thioanisole, thiophenol), sulfoxides (DMSO, di-Ph sulfoxide) and di-Ph sulfide, most of which are generally accepted as being inert to nitroso groups, is reported here. The tetrazolium-activated nitroso functionality is capable of oxidizing the aforementioned substrates to give the corresponding oxidized products e.g., azobenzene, and the nitroso tetrazolium itself is transformed into the corresponding amide or hydroxyamide I [R = NH-, O-], depending on the nature of the reaction partners. In the case of thioanisole, an addition product II•BF4- was obtained.

Bulletin of the Chemical Society of Japan published new progress about Anisoles Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Jing-Hao published the artcileThiol Activation toward Selective Thiolation of Aromatic C-H Bond, Name: 1,3-Dimethoxybenzene, the main research area is thiophenol aryl ether regioselective electrochem thiolation; diaryl thioether preparation.

An effective model for regioselective thiolation of the aromatic C-H bond by thiol activation instead of arene activation was disclosed. This method was applied into anisole derivatives that are not available in the arene activation approach to forge a single thioether isomer with high reactivity.

Organic Letters published new progress about Anisoles Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tu, Guangliang published the artcileLigand-Promoted Nickel-Catalyzed para-Selective Carboxylation of Anisoles, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is anisole regioselective carboxylation bromoform radical nickel catalyst.

It has always been a challenge in free radical chem. to control site selectivity during the reaction of free radicals with aromatic rings. Herein, the site-selective carboxylation of anisoles through the direct reaction of the bromoform radical with a benzene ring at the para position under the assistance of 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline with nickel(II) as the catalyst is reported. A wide variety of anisoles were compatible, leading to para-carboxylated products in moderate to good yields. A preliminary mechanistic study suggested that the Ni(II) complex coordinates with the methoxyl group of the aromatic ring, which may have increased the steric hindrance at the ortho and meta positions, while this weak interaction reduces the aromaticity of the aromatic ring, affording an activated Ph ring, thereby leading to highly para-selective carboxylation.

Organic Letters published new progress about Anisoles Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sukowski, Verena published the artcileS,O-Ligand-Promoted Pd-Catalyzed C-H Olefination of Anisole Derivatives, Name: 1,3-Dimethoxybenzene, the main research area is anisole olefination palladium catalyst.

The C-H olefination of substituted anisole derivatives by a Pd/S,O-ligand catalyst is reported. The reaction proceeds under mild conditions with a broad range of substituted aryl ethers bearing both electron donating and withdrawing substituents at ortho, meta and para positions. Aryl ethers are used as limiting reagents and good yields and site selectivities are observed The methodol. is operationally simple and can be performed under aerobic conditions.

European Journal of Organic Chemistry published new progress about Anisoles Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kang, Qi-Kai published the artcileCatalytic SNAr Hydroxylation and Alkoxylation of Aryl Fluorides, Computed Properties of 151-10-0, the main research area is phenol preparation DFT mechanistic study; water aryl fluoride hydroxylation rhodium catalyst; ester preparation DFT mechanistic study; aryl fluoride alc alkoxylation rhodium catalyst; C−O bond formation; Meisenheimer-type intermediate; rhodium; η6-coordination.

A reliable method for accessing phenols ArOH (Ar = C6H5, 4-CH3OC6H4, 9H-fluoren-2-yl, etc.) and Ph alkyl ethers Ar1OR (Ar1 = 4-CH3C6H4, 9H-fluoren-2-yl, 1-methyl-2-oxo-2,3-dihydro-1H-indol-5-yl, etc.; R = Me, cyclohexylmethyl, oxan-4-yl, etc.) via catalytic SnAr reactions has been described. The method is applicable to a broad array of electron-rich and neutral aryl fluorides ArF and Ar1F, which are inert under classical SnAr conditions. Although the mechanism of SNAr reactions involving metal arene complexes is hypothesized to involve a stepwise pathway (addition followed by elimination), exptl. data that support this hypothesis is still under exploration. Mechanistic studies and DFT calculations suggest either a stepwise or stepwise-like energy profile. Notably, a rhodium η5-cyclohexadienyl complex intermediate with an sp3-hybridized carbon bearing both a nucleophile and a leaving group was isolated.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Huang, Ming published the artcileRuthenium(II) complexes with N-heterocyclic carbene-phosphine ligands for the N-alkylation of amines with alcohols, COA of Formula: C8H11NO, the main research area is secondary arylamine preparation; amine alc alkylation ruthenium phosphine ligand catalyst.

Metal hydride complexes are key intermediates for N-alkylation of amines with alcs. by the borrowing hydrogen/hydrogen autotransfer (BH/HA) strategy. Reactivity tuning of metal hydride complexes could adjust the dehydrogenation of alcs. and the hydrogenation of imines. Herein we report ruthenium(II) complexes with hetero-bidentate N-heterocyclic carbene (NHC)-phosphine ligands, which realize smart pathway selection in the N-alkylated reaction via reactivity tuning of [Ru-H] species by hetero-bidentate ligands. In particular, complex I·BArF- with a Ph wingtip group and BArF- counter anion, is shown to be one of the most efficient pre-catalysts for this transformation (temperature is as low as 70°C, neat conditions and catalyst loading is as low as 0.25 mol%). A large variety of (hetero)aromatic amines and primary alcs. were efficiently converted into mono-N-alkylated amines in good to excellent isolated yields. Notably, aliphatic amines, challenging methanol and diamines could also be transformed into the desired products. Detailed control experiments and d. functional theory (DFT) calculations provide insights to understand the mechanism and the smart pathway selection via [Ru-H] species in this process.

Organic & Biomolecular Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Huang, Ming published the artcileRoom temperature N-heterocyclic carbene manganese catalyzed selective N-alkylation of anilines with alcohols, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is secondary amine preparation; aniline alc alkylation heterocyclic carbene manganese catalyst.

The first example of room temperature non-noble metal homogeneous system catalyzed selective N-alkylation of anilines with alcs. by a bis-NHC manganese complex is presented. This system was applied to a large range of alcs. and anilines, including biol. relevant motifs and challenging methanol. Exptl. and computational studies suggest an outer-sphere mechanism for this NHC-Mn system.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ma, Zhuang published the artcileReusable Co-nanoparticles for general and selective N-alkylation of amines and ammonia with alcohols, SDS of cas: 5961-59-1, the main research area is doped carbon supported cobalt nanoparticle preparation; alkylated amine selective preparation; alc amine alkylation cobalt nanocatalyst; ammonia alc alkylation cobalt nanocatalyst.

A general cobalt-catalyzed N-alkylation of amines with alcs. by borrowing hydrogen methodol. to afford alkylated amines I [R = Pr-n, cyclohexyl, Ph, etc.; R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.] was reported. The optimal catalyst for this transformation was prepared by pyrolysis of a specific templated material, which was generated in situ by mixing cobalt salts, nitrogen ligands and colloidal silica and subsequent removal of silica. Applying this novel Co-nanoparticle-based material, >100 primary, secondary and tertiary amines including N-methylamines and selected drug mols. were conveniently prepared starting from inexpensive and easily accessible alcs. and amines or ammonia.

Chemical Science published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, SDS of cas: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sagadevan, Arunachalam published the artcileCopper Photoredox Catalyzed A3′ Coupling of Arylamines, Terminal Alkynes, and Alcohols through a Hydrogen Atom Transfer Process, Category: isoquinoline, the main research area is propargylamine preparation; alkylaniline terminal alkyne alc three component coupling; hydrogen atom transfer photoredox copper catalyst; amines; copper; photochemistry; radicals; synthetic methods.

The first successful example of the three-component coupling of N-alkylanilines, terminal alkynes, and alcs. was achieved at room temperature by a visible-light-mediated copper-catalyzed photoredox hydrogen-atom transfer process. This method allows preparation of propargylamines I (R1 = H, 4-Me, 3-I, etc.; R2 = Me, n-Bu, Bn, etc.; R3 = C6H5, 3-MeC6H4, 3-thienyl, etc.; R4 = H, Me, c-Pr, etc.) through uniquely selective α-C-H bond activation of unactivated alkylalcs. Preliminary studies indicate that formation of α-oxy radical is operative. This approach facilitates rapid access to biol. important propargylamines from methanol as an abundant feedstock.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Donthireddy, S. N. R. published the artcileRuthenium(II) Complexes of Heteroditopic N-Heterocyclic Carbene Ligands: Efficient Catalysts for C-N Bond Formation via a Hydrogen-Borrowing Strategy under Solvent-Free Conditions, Safety of 4-Methoxy-N-methylaniline, the main research area is ruthenium imidazolylidene triazolylidene complex preparation crystal structure benzylation catalyst; crystal structure ruthenium imidazolylidene triazolylidene complex; mol structure ruthenium imidazolylidene triazolylidene complex; benzyl alc coupling reaction benzylation aniline derivative carbeneruthenium catalyst; quinoline derivative preparation.

Both imidazol-2-ylidene (ImNHC) and 1,2,3-triazol-5-ylidene (tzNHC) have evolved to be elite groups of N-heterocyclic carbene (NHC) ligands for homogeneous catalysis. To develop efficient Ru(II)-based catalysts incorporating these ligands for C-N bond-forming reactions via H-borrowing methodol., the authors used chelating ligands integrated with ImNHC and mesoionic tzNHC donors connected via a CH2 spacer with a diverse triazole backbone. The synthesized Ru(II) complexes 3 are highly efficient for C-N bond formation across a wide range of primary amine and alc. substrates under solvent-free conditions, and among all of the complexes studied here, catalyst 3a with a mesityl substituent displayed maximum activity. Catalyst 3a is also effective for the selective mono-N-methylation of various anilines using MeOH as a coupling partner, known to be relatively more difficult than other alcs. Also, complex 3a also delivers various substituted quinolines successfully via the reaction of 2-aminobenzyl alc. with several secondary alcs. Importantly, catalyst 3a exhibited the highest activity among the reported Ru(II) complexes for both the N-benzylation of aniline [achieving a turnover number (TON) of 50000] and the realization of quinoline 8a by reacting 2-aminobenzyl alc. with 2-phenylethanol (attaining a TON of 30000). The significance of electronic tuning in the Ru(II) complexes of chelating ligands featuring a combination of ImNHC and tzNHC donors with various triazole backbones is demonstrated by applying them in diverse C-N bond-forming reactions via a H-borrowing strategy. Notably, the Ru(II) complex 3a having an N-mesityl substituent displayed the highest activity among known Ru(II) complexes for both the N-benzylation of aniline [a turnover number (TON) of 50000] and the synthesis of quinoline via the reaction of 2-aminobenzyl alc. with 2-phenylethanol (a TON of 30000).

Inorganic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem