Tag: M.W=150-200

Liew, Lydia P. published the artcileHypoxia-Activated Prodrugs of PERK Inhibitors, Formula: C9H10O3, the main research area is hypoxia prodrug drug delivery PERK kinase inhibitor antitumor; drug delivery; hypoxia; kinase inhibitor; nitroimidazole; prodrug.

Tumor hypoxia plays an important role in tumor progression and resistance to therapy. Under hypoxia unfolded proteins accumulate in the endoplasmic reticulum (ER) and this stress is relieved through the protein kinase R-like ER kinase (PERK) signaling arm of the unfolded protein response (UPR). Targeting the UPR through PERK kinase inhibitors provides tumor growth inhibition, but also elicits on-mechanism normal tissue toxicity. Hypoxia presents a target for tumor-selective drug delivery using hypoxia-activated prodrugs. We designed and prepared hypoxia-activated prodrugs of modified PERK inhibitors using a 2-nitroimidazole bioreductive trigger. The new inhibitors retained PERK kinase inhibitory activity and the corresponding prodrugs were strongly deactivated. The prodrugs were able to undergo fragmentation following radiolytic reduction, or bioreduction in HCT116 cells, to release their effectors, albeit inefficiently. We examined the effects of the prodrugs on PERK signaling in hypoxic HCT116 cells. This study has identified a 2-substituted nitroimidazole carbamate prodrug with potential to deliver PERK inhibitors in a hypoxia-selective manner.

Chemistry – An Asian Journal published new progress about Antitumor agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shergalis, Andrea published the artcileCharacterization of Aminobenzylphenols as Protein Disulfide Isomerase Inhibitors in Glioblastoma Cell Lines, Quality Control of 86-51-1, the main research area is aminobenzylphenol structure screening preparation PDIA1 inhibitor glioblastoma.

Disulfide bond formation is a critical post-translational modification of newly synthesized polypeptides in the oxidizing environment of the endoplasmic reticulum and is mediated by protein disulfide isomerase (PDIA1). In this study, we report a series of α-aminobenzylphenol analogs as potent PDI inhibitors. The lead compound, AS15, is a covalent nanomolar inhibitor of PDI, and the combination of AS15 analogs with glutathione synthesis inhibitor buthionine sulfoximine (BSO) leads to synergistic cell growth inhibition. Using nascent RNA sequencing, we show that an AS15 analog triggers the unfolded protein response in glioblastoma cells. A BODIPY-labeled analog binds proteins including PDIA1, suggesting that the compounds are cell-permeable and reach the intended target. Taken together, these findings demonstrate an extensive biochem. characterization of a novel series of highly potent reactive small mols. that covalently bind to PDI.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Quality Control of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hng, Yue published the artcileDesign and synthesis of 3-benzylaminocoumarin-7-O-sulfamate derivatives as steroid sulfatase inhibitors, Safety of 2,3-Dimethoxybenzaldehyde, the main research area is benzylaminocoumarin sulfamate synthesis anticancer SAR steroid sulfatase breast cancer; Breast cancer; Coumarin; Hormone dependent cancer; Irreversible inhibitors; Steroid sulfatase; Sulfamate.

Steroid sulfatase (STS) is a sulfatase enzyme that catalyzes the conversion of sulfated steroid precursors to free steroid. The inhibition of STS could abate estrogenic steroids that stimulate the proliferation and development of breast cancer, and therefore STS is a potential target for adjuvant endocrine therapy. In this study, a series of 3-benzylaminocoumarin-7-O-sulfamate derivatives targeting STS were designed and synthesized. Structure–activity relationship (SAR) anal. revealed that attachment of a benzylamino group at the 3-position of coumarin improved inhibitory activity. Compound 3j was found to have the highest inhibition activity against human placenta isolated STS (IC50 0.13 μM) and MCF-7 cell lines (IC50 1.35 μM). Kinetic studies found compound 3j to be an irreversible inhibitor of STS, with KI and kinact value of 86.9 nM and 158.7 min-1, resp.

Bioorganic Chemistry published new progress about Antitumor agents. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Safety of 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Wenjing published the artcileDesign, synthesis and biological evaluation of novel 4-(4-methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines as tubulin polymerization inhibitors, SDS of cas: 104-01-8, the main research area is methoxynaphthalenylarylpyrimidinamine preparation tubulin polymerization inhibitor antitumor; anticancer; naphthalene; pyrimidine; tubulin polymerization inhibitor.

A novel series of 4-(4-methoxynaphthalen-1-yl)-5-arylpyrimidin-2-amines I (R = 4-OEt, 4-Me, 4-Cl, etc.) were designed, synthesized, and evaluated for their anticancer activities. Most of the synthesized compounds exhibited moderate to high antiproliferative activity in comparison to the standard drug cisplatin. Among them, I (R = 4-OEt) was found to be the most active on MCF-7 and HepG2 cancer cell lines, with IC50 values of 3.77 +/= 0.36 and 3.83 +/= 0.26μM, resp. Further mechanism study shown that I (R = 4-OEt) potently inhibited tubulin polymerization, induced cell cycle arrest at G2/M phase and cell apoptosis in MCF-7 cell line. Furthermore, mol. modeling study suggested that I (R = 4-OEt) probably binds to the colchicine site of tubulin.

Chemical & Pharmaceutical Bulletin published new progress about Antitumor agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Dong, Junmin published the artcileDesign, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors, SDS of cas: 104-01-8, the main research area is exiguamine A preparation SAR mol docking antitumor indoleamine dioxygenase; Cancer immunotherapy; Exiguamine A; Indoleamine 2,3-dioxygenase 1.

A series of exiguamine A analogs were designed and synthesized via 15 steps. Their inhibitory activities against IDO1 were tested and the structure-activity relationships were studied. Most compounds exhibited potent IDO1 inhibitory activities with IC50 values at the level of 10-7-10-8 M. Compound I was the most potent IDO1 inhibitor with an IC50 value of 65.3 nM, which was comparable with the pos. control drug epacadostat (IC50 = 46 nM). Moreover, compound I showed higher selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) and no cytotoxicity at its effective concentration, rending it justifiable for further optimization and evaluation.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Dong, Junmin published the artcileDesign, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors, Computed Properties of 86-51-1, the main research area is exiguamine A preparation SAR mol docking antitumor indoleamine dioxygenase; Cancer immunotherapy; Exiguamine A; Indoleamine 2,3-dioxygenase 1.

A series of exiguamine A analogs were designed and synthesized via 15 steps. Their inhibitory activities against IDO1 were tested and the structure-activity relationships were studied. Most compounds exhibited potent IDO1 inhibitory activities with IC50 values at the level of 10-7-10-8 M. Compound I was the most potent IDO1 inhibitor with an IC50 value of 65.3 nM, which was comparable with the pos. control drug epacadostat (IC50 = 46 nM). Moreover, compound I showed higher selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) and no cytotoxicity at its effective concentration, rending it justifiable for further optimization and evaluation.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Computed Properties of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Xinyu published the artcileSynthesis and biological evaluation of 3-aryl-quinoline derivatives as anti-breast cancer agents targeting ERα and VEGFR-2, Related Products of isoquinoline, the main research area is antitumor arylquinoline estrogen receptor alpha VEGFR 2 multi target; arylquinoline SAR anti breast cancer multi target; Anti-breast cancer; Estrogen receptor; Multi target; VEGFR-2.

Selective estrogen receptor modulators(SERMs) are a series of important small mol. compounds to modulate the estrogen receptor, such as tamoxifen. Although these drugs have shown great benefits in the treatment of breast cancer, the risk of endometrial cancer and endocrine resistance restrict their use. The reasonable designing of multi-target drugs can decrease the side effects and improve the tolerance of antineoplastic agents. Studies have identified that VEGFR-2 plays a pivotal role in tumor angiogenesis and drug resistance. Besides, a combination of Tamoxifen and a low dose of a VEGFR-2 inhibitor was reported to maximize therapeutic efficacy as well as to retard SERM resistant tumor growth. In this work, a series of 3-aryl-quinoline derivatives were designed to target ERα and VEGFR-2 to eliminate the disadvantages of SERMs. We identified that compounds I [R1 = H, R2 = MeO; R1 = MeO, R2 = H] displayed highly ER binding affinities as well as relative intensity VEGFR-2 inhibitory activities. Moreover, these two compounds exhibited excellent anti-proliferative activities against MCF-7 and HUVEC cell lines with low micromolar IC50 (1-8 μM). A further study confirmed that compound I [R1 = MeO, R2 = H] can reduce the expression of PgR mRNA, arrest cell cycle in MCF-7 breast cancer cells, and restrain the cell migration. Overall, based on the biol. activities data, I [R1 = MeO, R2 = H] can be chosen as a potential anti-cancer lead compound for further studying.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Destro, Gianluca published the artcileTransition-Metal-Free Carbon Isotope Exchange of Phenyl Acetic Acids, COA of Formula: C9H10O3, the main research area is transition metal free carbon isotope exchange phenylacetic acid; carbon dioxide; carbon-11; carbon-14; isotope exchange; isotope labeling.

A transition-metal-free carbon isotope exchange procedure on Ph acetic acids is described. Utilizing the universal precursor CO2, this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with carbon isotopes [14C] and [13C]. A proof of concept with [11C] was also obtained with low molar activity valuable for distribution studies.

Angewandte Chemie, International Edition published new progress about Exchange reaction. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yang, Huilin published the artcileExploring functional core bacteria in fermentation of a traditional Chinese food, Aspergillus-type douchi, Product Details of C13H16O, the main research area is Aspergillus douche traditional Chinese food fermentation bacteria.

Douchi is a type of traditional Chinese flavoring food that has been used for thousands of years and is produced by multispecies solid-state fermentation However, the correlation between the flavor, the microbiota, and the functional core microbiota in Aspergillus-type douchi fermentation remains unclear. In this study, Illumina MiSeq sequencing and chromatog. were used to investigate the bacterial community and flavor components in Aspergillus-type douchi fermentation The dominant phyla were Firmicutes, Proteobacteria, and Actinobacteria, and the dominant genera were Weissella, Bacillus, Anaerosalibacter, Lactobacillus, Staphylococcus, and Enterococcus. A total of 58 flavor components were detected during fermentation, including two alcs., 14 esters, five pyrazines, three alkanes, four aldehydes, three phenols, six acids, and five other compounds Bidirectional orthogonal partial least square modeling showed that Corynebacterium_1, Lactococcus, Atopostipes, Peptostreptococcus, norank_o__AKYG1722, Truepera, Gulosibacter, norank_f__Actinomycetaceae, and unclassified_f__Rhodobacteraceae are the functional core microbiota responsible for the formation of the flavor components during douchi fermentation This is the first study to investigate the functional core microbiota in douchi fermentation using Illumina MiSeq sequencing and chromatog. techniques. Our findings extend our understanding of the relationships between flavor, the microbiota, and the functional core microbiota during Aspergillus-type douchi fermentation

PLoS One published new progress about Actinomycetaceae. 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Product Details of C13H16O.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tak, Jun-Hyung published the artcileScreening for enhancement of permethrin toxicity by plant essential oils against adult females of the yellow fever mosquito (Diptera: Culicidae), Synthetic Route of 1205-17-0, the main research area is Diptera Culicidae fever permethrin toxicity essential oil screening; chlorpyrifos-methyl; cucumber seed oil; insecticide synergism; plant essential oils.

Aedes aegypti L. (Diptera: Culicidae) is one of the most medically important mosquito species, due to its ability to spread viruses of yellow fever, dengue fever, and Zika in humans. In this study, the insecticidal activity of 17 plant essential oils was evaluated via topical application against two strains of Ae. aegypti mosquito, Orlando (insecticide-susceptible) and Puerto Rico (pyrethroid-resistant). Initial screens with the Orlando strain showed that cucumber seed oil (2017 sample) was the most toxic, followed by sandalwood and thyme oil. When the essential oils were mixed with permethrin, they failed to show any significant synergism of insecticidal activity. Sandalwood and thyme oils displayed consistently high mortality against the resistant Puerto Rico strain, with low resistance ratios of 2.1 and 1.4, resp. In contrast, cucumber seed oil showed significantly less activity against Puerto Rico mosquitoes, with a resistance ratio of 45. Bioactivity-guided fractionation of the 2017 sample of cucumber seed oil sample via flash column chromatog. produced 11 fractions, and gas-chromatog./mass spectrometry anal. revealed that the three active fractions were contaminated with 0.33, 0.36, and 0.33% of chlorpyrifos-Me, an organophosphorus insecticide, whereas inactive fractions did not show any trace of it. These results suggested that the insecticidal activity of cucumber seed oil was probably due to the presence of the insecticide, later confirmed with a clean batch of cucumber seed oil obtained in 2018, which showed negligible insecticidal activity. These findings demonstrate clearly the need for essential oil anal. to confirm purity before any claims are made about pesticidal potency.

Journal of Medical Entomology published new progress about Adult, mammalian. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Synthetic Route of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem