Tag: M.W=150-200

Naeimi, Hossein published the artcileMultisulfonate hyperbranched polyglycerol functionalized graphene oxide as an efficient reusable catalyst for green synthesis of benzo[a]pyrano-[2,3-c]phenazines under solvent-free conditions, Application of 2,3-Dimethoxybenzaldehyde, the main research area is multisulfonate polyglycerol functionalized graphene oxide catalyst benzopyranophenazine green preparation.

A novel acid catalyst was prepared based on growing hyperbranched polyglycerol (HPG) on the surface of graphene oxide. Then, the hydroxyl groups of HPG on graphene oxide were functionalized by sulfonate groups to form an acid catalyst. The catalyst displayed a good loading level of acidic groups on the surface because of coating graphene oxide with HPG. This new catalyst is demonstrated to be highly effective in the preparation of benzo[a]pyrano[2,3-c]phenazine dyes.

RSC Advances published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application of 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Din, Zia Ud published the artcileSymmetrical and unsymmetrical substituted 2,5-diarylidene cyclohexanones as anti-parasitic compounds, Synthetic Route of 1205-17-0, the main research area is diarylidene cyclohexanone sym unsym preparation antiparasitic mol docking; 2,5-diarylidene cyclohexanones; Anti-parasitic; DFT analysis; Docking; T cruzi.

Sym. and unsym. bis-aryl-α,β-unsaturated ketones I (R = Ph, 4-MeOC6H4, 2-ClC6H4, etc.) and II [R1 = R2 = H, R3 = OMe, R4 = Ph, 4-MeNC6H4, 2,3-(MeO)2C6H3, 4-O2NC6H4, etc.; R1 = R2 = OMe, R3 = H, R4 = Ph, 4-BrC6H4, 2,6-Cl2C6H3, 2-MeO-4-O2NC6H3, etc.] were synthesized in moderate to excellent yield by treating cyclohexanone with various aldehydes. Dimethylammonium dimethylcarbamate (DIMCARB) was used as both catalyst and reaction medium for the synthesis of monoarylidenes cycloadduct intermediates, which were further used to produce diarylidene cyclohexanones. All 34 compounds synthesized were evaluated for their anti-proliferative activity, particularly against promastigote of Leishmania amazonensis, epimastigote and trypomastigote of Trypanosoma cruzi. Eighteen compounds displayed anti-leishmanial activity against promastigotes of L. amazonensis with IC50 values ranging from 2.8 to 10 μM. In addition, two compounds exhibited significant antitrypanosomal activity against epimastigotes of T. cruzi with IC50 values of 5.2±0.8 and 3.0±0.0μM, while five compounds exhibited activity from 15.0±1.4 to 30.2±1.8μM against trypomastigote of T. cruzi. Moreover, all compounds were more selective against the parasites than the epithelial cells. The unsym. compounds II [R1 = R2 = H, R3 = MeO, R4 = 2,3-(MeO)2C6H3; R1 = R2 = MeO, R3 = H, R4 = 4-O2NC6H4, 3,4,5-(MeO)3C6H2, 3,4-(MeO)2C6H3] can be considered as favorable anti-parasitic lead mols. having IC50 and EC50 values in the low-micromolar range, better than the reference drug benznidazole, and low cytotoxicity against Vero cells. The potent compounds were screened in silico against 17 enzymes of T. cruzi and the best scoring were found against Dihydroorotate Dehydrogenase.

European Journal of Medicinal Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Synthetic Route of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shirzaei, Farhad published the artcilePreparation of novel functionalized ionic liquid: Green, stable, and reusable catalyst for the synthesis of new 2-(phenylsulfonyl)-1H-benzo[a]pyrano[2,3-c]phenazin-3-amine derivatives, Application of 2,3-Dimethoxybenzaldehyde, the main research area is phenylsulfonyl benzopyranophenazinamine green preparation; naphthalenedione phenylenediamine arylaldehyde phenylsulfonyl acetonitrile multicomponent ionic liquid.

A new functionalized stable ionic liquid as 3-(triethoxysilyl)propane-1-aminium formate was prepared and characterized. The ionic liquid as a novel catalyst was carried out for the synthesis of new 2-(phenylsulfonyl)-1H-benzo[a]pyrano[2,3-c]phenazinamines I [R = H, 3-OH, 4-Br, etc.] via four-component reaction of 2-hydroxynaphthalene-1,4-dione, o-phenylenediamine, arylaldehydes, and (phenylsulfonyl)acetonitrile. A simple and an efficient procedure for the synthesis of new unknown compounds using a green and novel reusable ionic liquid as catalyst under solvent-free and thermal conditions was reported. The easy preparation of ionic liquids without any toxic solvent, short reaction times and simple work-up with excellent yields are advantages of the present reaction.

Journal of Molecular Liquids published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application of 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Rao, Dasari Jagadeeswara published the artcileMicrowave irradiated mild, rapid, one-pot and multi-component synthesis of isoxazole-5(4H)-ones, Product Details of C9H10O3, the main research area is isoxazolone preparation green chem; aldehyde ethylacetoacetate hydroxylamine multicomponent tandem reaction microwave irradiation.

A swift, environmental-friendly and efficient protocol for the synthesis of isoxazole-5(4H)-one derivatives through multicomponent reaction of substituted aldehydes, ethylacetoacetate and hydroxylamine is designed by MWI under catalyst-free condition. The noticeable features of this protocol are: simple handling, environmental-benign, catalyst-free, avoid of harmful catalysts, short reaction time (≤ 10), energy conserving, no toxic byproducts and excellent yields (93-98%).

Chemical Data Collections published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Product Details of C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Noruzian, Fatemeh published the artcileGuanidine hydrochloride catalyzed efficient one-pot pseudo five-component synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) in water, Related Products of isoquinoline, the main research area is arylmethylene pyrazolols preparation green chem; hydrazine acetoacetate aldehyde Knoevenagel Michael reaction guanidine hydrochloride catalyst.

The present methodol. describes an efficient, environmentally friendly and simple protocol for the synthesis of some 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives through a one-pot pseudo-five-component reaction of hydrazine hydrate/phenyl hydrazine, Et acetoacetate, and various aromatic aldehydes catalyzed by guanidine hydrochloride. This condensation reaction was performed by tandem Knoevenagel-Michael reaction in water under refluxing conditions giving the title compounds in 82-92% yields. Atom economy, simple operation, easy work-up, using inexpensive organocatalyst, high yields in short times, clean transformation, and environmentally benign are some of the important features of this new protocol.

Synthetic Communications published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Maddila, Surya Narayana published the artcileMnO2 on hydroxyapatite: A green heterogeneous catalyst and synthesis of pyran-carboxamide derivatives, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is aldehyde acetoacetanilide malononitrile manganese oxide hydroxyapatite catalyst multicomponent water; pyran carboxamide green preparation.

Three different loadings of MnO2 on hydroxyapatite (MnO2/Hap) were synthesized and the hydroxyapatite supported MnO2 materials were characterized by several anal. techniques including FT-IR, P-XRD, TEM and SEM anal. 3% MnO2/HAp material proved highly efficient catalyst for the synthesis of a series of ten pyran-carboxamide derivatives (yield 91-98%) in aqueous medium at room temperature (RT) conditions, via one-pot multi-component reaction, of which nine were new moieties. The prominent features of the protocol are excellent yields, high atom efficiency, short reaction times (15 min), recyclable catalyst and no need for column separation

Inorganic Chemistry Communications published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Jing published the artcileMicrowave-assisted multicomponent reaction: An efficient synthesis of indolyl substituted and spiroxindole pyrido[2,3-d]pyrimidine derivatives, SDS of cas: 86-51-1, the main research area is indolyl spiroxindole pyridopyrimidine preparation microwave irradiation; diaminopyrimidinone aryl aldehyde isatin cyanoacetyl indole three component reaction; tandem Knoevenagel condensation Michael addition.

An efficient and catalyst-free protocol for the synthesis of a series of indole substituted I (R = H, Me; R1 = H, 7-Me; Ar = Ph, 4-FC6H4, 2-thienyl, etc.) or spiroxindole-consisted dihydropyrido[2,3-d]pyrimidine derivatives II (R = H, Me; R1 = H, 7-Me; R2 = H, 5-Me, 5-F, 5-Br) by one-pot three-component reaction of 2,6-diaminopyrimidin-4-one, various aryl aldehydes or isatins, and 3-cyanoacetyl indoles under microwave irradiation was investigated. The advantages of this methodol. include high yields of products, short reaction time, easy work-up procedure and broad substrate scope.

Synthetic Communications published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, SDS of cas: 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Khosravi, Zeynab published the artcileFe3O4@SiO2@sulfated boric acid as superparamagnetic and recyclable nanocatalyst-assisted, one-pot, pseudo four-component synthesis of 5-amino-2-aryl-3H-chromeno[4,3,2-de][1,6]naphthyridine-4-carbonitrile derivatives, Related Products of isoquinoline, the main research area is magnetite silica boric acid sulfated chromeno naphthyridine recyclability stability.

The catalytic performance of the superparamagnetic nanocatalyst Fe3O4@SiO2@Sulfated boric acid as a green, recyclable, and acidic solid catalyst in the synthesis of chromeno[4,3,2-de][1,6]naphthyridine derivatives has been studied. Chromeno[4,3,2-de][1,6]naphthyridine derivatives via a pseudo four-component reaction from aromatic aldehydes (1 mmol), malononitrile (2 mmol), and 2′-hydroxyacetophenone in the presence of Fe3O4@SiO2@Sulfated boric acid (0.004 g) as a nanocatalyst in 3 mL of water as a green solvent at 80°C has been synthesized. The advantages of this method are higher product yields in shorter reaction times, easy recyclability and reusability of the catalyst, and easy work-up procedures. The nanocatalyst was reused at least six times. The nanocatalyst retained its stability in the reaction, and after reusability, it was separated easily from the reaction by an external magnet.

Journal of the Chinese Chemical Society (Weinheim, Germany) published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jing, Ke published the artcileVisible-light photoredox-catalyzed carboxylation of benzyl halides with CO2: Mild and transition-metal-free, COA of Formula: C9H10O3, the main research area is aryl acetic acid preparation visible light; benzyl chloride bromide carbon dioxide carboxylation photoredox catalyst.

The visible-light photoredox-catalyzed carboxylation of benzyl chlorides and bromides with CO2 has been reported. With inexpensive organic dyes as photocatalysts and amines as electron donors, this carboxylation proceeds well in the absence of sensitive organometallic reagents, transition metal catalysts, or metallic reductants. A wide range of com. available and inexpensive benzyl halides undergo such carboxylation to give valuable aryl acetic acids, including several pharmaceutical mols. and drug precursors, in moderate to high yields. Moreover, this reaction features mild reaction conditions (one atm. pressure of CO2 and room temperature), broad substrate scope, good functional group tolerance, easy scalability, and low catalyst loading, thus providing an efficient approach for the assembly of aryl acetic acids.

Chinese Journal of Catalysis published new progress about Benzyl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bazyar, Zahra published the artcileOn/Off O2 Switchable Photocatalytic Oxidative and Protodecarboxylation of Carboxylic Acids, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is photocatalytic oxidative protodecarboxylation carboxylic acid.

Photoredox catalysis in recent years has manifested a powerful branch of science in organic synthesis. Although merging photoredox and metal catalysts has been a widely used method, switchable heterogeneous photoredox catalysis has rarely been considered. Herein, we open a new window to use a switchable heterogeneous photoredox catalyst which could be turned on/off by changing a simple stimulus (O2) for two opponent reactions, namely, oxidative and protodecarboxylation. Using this strategy, we demonstrate that Au@ZnO core-shell nanoparticles could be used as a switchable photocatalyst which has good catalytic activity to absorb visible light due to the localized surface plasmon resonance effect of gold, can decarboxylate a wide range of aromatic and aliphatic carboxylic acids, have multiple reusability, and are a reasonable candidate for synthesizing both aldehydes/ketones and alkane/arenes in a large-scale set up. Some biol. active mols. are also shown via examples of the direct oxidative and protodecarboxylation which widely provided pharmaceutical agents.

Journal of Organic Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem