Tag: M.W=150-200

Hu, Sha published the artcileTfOH-Catalyzed Cascade C-H Activation/Lactonization of Phenols with α-Aryl-α-diazoesters: Rapid Access to α-Aryl Benzofuranones, Name: 4-Methoxyphenylacetic acid, the main research area is arylbenzofuranone synthesis triflic acid catalyzed cascade phenol aryldiazoacetate.

Aryl benzofuranones are privileged structural units present in natural products and pharmaceutically relevant compounds with high bioactivity and therapeutic value; synthetic access to these scaffolds remains an area of intensive interest. A new and efficient TfOH-catalyzed cascade ortho C-H activation/lactonization of phenols with α-aryl-α-diazoacetates is reported. This metal-free protocol provides an operationally simple and rapid method for the one-pot assembly of diverse α-aryl benzofuranones in high yields with broad substrate scope, a readily starting material, good chemo-regioselectivity, and excellent functional group compatibility.

Journal of Organic Chemistry published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yazdanseta, Saeed published the artcileAnchoring Cu (II) on Fe3O4@ SiO2/Schiff base: a green, recyclable, and extremely efficient magnetic nanocatalyst for the synthesis of 2-amino-4H-chromene derivatives, Synthetic Route of 86-51-1, the main research area is preparation copper iron oxide silica Schiff green recyclable nanocatalyst; thermal decomposition copper iron oxide silica Schiff recyclable nanocatalyst; aromatic aldehyde preparation; copper iron oxide silica Schiff recyclable nanocatalyst.

Abstract: a novel water-soluble Salen type Cu(II) Schiff base complex functionalized silica-coated magnetite nanoparticles [Fe3O4@SiO2/Schiff base of Cu(II)] was synthesized and characterized. First, an immobilized water-soluble Schiff base was synthesized from the condensation reaction between 3-amino Pr triethoxy silane (APTES) functionalized silica-coated magnetite nanoparticles and a water-soluble aldehyde (sodium salicylaldehyde-5-sulfonate monohydrate). After that, functionalized Schiff base was converted to functionalized Cu(II) Schiff base complex as the result of reaction with Cu(II) acetate tetrahydrate. The structural and magnetic properties of the prepared compounds were identified by FTIR, XRD, SEM, EDX, TEM, VSM, and TGA. The catalytic activity of the novel nanocatalyst was studied for the preparation of 2-amino-4H-chromene derivatives through an one-pot, three-component reaction of dimedone, aromatic aldehydes, and malononitrile, in the presence of catalytic amounts of the Fe3O4@SiO2/Schiff base of Cu(II) nanocatalyst in water and at room temperature The 2-amino-4H-chromene derivatives were obtained in good to excellent yields. Furthermore, because of the solubility of metal Schiff base complexes in water, the nanocatalyst dispersed in water easily without using ultrasonic or shaker.

Research on Chemical Intermediates published new progress about Benzopyrans Role: SPN (Synthetic Preparation), PREP (Preparation). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Synthetic Route of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pham, Phuc H. published the artcileFunctionalization of C-H bonds in acetophenone oximes with arylacetic acids and elemental sulfur, Synthetic Route of 104-01-8, the main research area is fused thienothiazole preparation; acetophenone ketoxime arylacetic acid sulfur coupling.

Fused thieno[3,2-d]thiazoles were synthesized via a coupling of acetophenone ketoximes, arylacetic acids, and elemental sulfur in the presence of Li2CO3 base. Functionalities including chloro, bromo, fluoro, trifluoromethyl, and pyridyl groups were compatible with reaction conditions. High yields and excellent regioselectivities were obtained even if meta-substituted ketoxime acetates were used. Et esters of heteroarylacetic acids were competent substrates, which is very rare in the literature. This method would offer a convenient protocol to afford polyheterocyclic structures from simple substrates.

RSC Advances published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Tianxiao published the artcileDecarboxylative Thiolation of Redox-Active Esters to Thioesters by Merging Photoredox and Copper Catalysis, Quality Control of 104-01-8, the main research area is benzothioic acid ester chemoselective photochem preparation; thiol sulfonyl fluoride preparation; ruthenium copper catalyst decarboxylation thiolation hydroxyphthalimide ester benzothioic acid; chemoselective photochem decarboxylation thiolation hydroxyphthalimide ester.

In the presence of [Ru(bpy)3]Cl2, CuBr, 2,2′-bipyridine, and Ph3P, redox-active alkylcarboxylic acid N-hydroxyphthalimide esters such as N-hydroxyphthalimidyl cyclohexanecarboxylate underwent chemoselective photochem. decarboxylation and thiolation with benzenethioic acid PhCOSH mediated by Et3N in MeCN under blue LED irradiation to yield benzothioic acid thioesters such as c-C6H11SCOPh. Primary, secondary, and tertiary thiol esters were prepared by this method. Selected thioesters were converted to free thiols and to alkanesulfonyl fluorides.

Organic Letters published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Quality Control of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Grell, Yvonne published the artcileEnantioselective α-Fluorination and α-Chlorination of N-Acyl Pyrazoles Catalyzed by a Non-C2-Symmetric Chiral-at-Rhodium Catalyst, Application In Synthesis of 104-01-8, the main research area is chiral rhodium catalyst preparation; fluorinated alpha chlorinated acyl pyrazole enantioselective preparation; acyl pyrazole chiral rhodium catalyst fluorination chlorination.

A non-C2-sym. and sterically demanding chiral-at-rhodium catalyst was demonstrated to efficiently catalyze the highly enantioselective α-fluorination [up to >99% enantiomeric excess (ee)] and α-chlorination (up to 98% ee) of N-acyl pyrazoles to afford α-fluorinated/chlorinated N-acyl pyrazoles I [R = Pr, Ph, 3-thienyl, ets.; R1 = F, Cl] in high yields. Based on two sterically distinct cyclometalating ligands, the nonracemic rhodium(III) catalyst could conveniently be accessed in an enantiomerically pure fashion (>99% ee) via an established auxiliary-mediated approach. Comparison of the catalytic performance with the related C2-sym. rhodium catalysts revealed the explicit superiority of the non-C2-sym. design for the presented α-halogenation reactions, which were generally featured by a very simple synthetic protocol.

ACS Catalysis published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Roque, Ana Carolina Abbud Hanna published the artcileConformational analysis for infrared spectroscopy and theoretical calculations of some 2-bromo-2-propyl 2-aryl-acetates, ibuprofen and naproxen analogs, Application of 4-Methoxyphenylacetic acid, the main research area is bromopropyl arylacetate ibuprofen naproxen analog conformation IR spectroscopy.

Conformational anal. of new para-substituted 2-bromo-2-Pr 2-aryl-acetates (Y = H, OMe, Cl, and NO2) (R1), ibuprofen (R2), and naproxen (R3) analogs using IR (IR) spectroscopy and theor. calculations was performed to determine the preferential conformers of these compounds in solvents with increasing polarity (CCl4, CH3Cl, and CH3CN). The aryl-bromo-esters were synthesized via the esterification of 2-bromo-2-methylpropan-1-ol and the corresponding carboxylic acids, with good yields (∼36-70%). The IR spectra showed that these compounds presented only one conformation, and the exptl. data were supported by the theor. results obtained by d. functional theory (DFT) calculations using the 6311+G (2df, 2p) basis set. The calculations revealed that all the studied compounds presented two stable geometric conformations, which agrees with the data obtained exptl. in CCl4. Theses conformers are stabilized by intramol. hydrogen bonds. However, the orbital interaction calculations using the natural bond orbital (NBO) method showed that the ηO→σ*C-C,ηO→σ*C-O, ηO→σ*C-O and ηO→π*C-O hyper-conjugations are the main interactions that stabilize the conformations. The compounds preferentially adopt the anti-conformation because the steric effect between the gauche bromo and oxygen atoms overrides the hyper-conjugative interactions, in addition to the stabilizing σC-H→ σ*C-Br interactions in the conformers.

Journal of Molecular Structure published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Shuaishuai published the artcileDecarboxylative tandem C-N coupling with nitroarenes via SH2 mechanism, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is aryl tertiary amine preparation; nitroarene carboxylic acid tandem decarboxylative coupling iron catalyst photochem.

In this paper, a radical tandem C-N coupling strategy to efficiently construct aromatic tertiary amines from com. available carboxylic acids and nitroarenes was developed. A variety of aromatic tertiary amines were furnished in good yields (up to 98%) with excellent functional group compatibility under mild reaction conditions. The use of two different carboxylic acids also allowed for the concise synthesis of nonsym. aromatic tertiary amines in satisfactory yields. Mechanistic studies suggested the intermediacy of the arylamine-(TPP)Fe(III) species and might provide a possible evidence for an SH2 (bimol. homolytic substitution) pathway in the critical C-N bond formation step.

Nature Communications published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Brauer, Jan published the artcileNickel-Mediated Photoreductive Cross Coupling of Carboxylic Acid Derivatives for Ketone Synthesis, SDS of cas: 104-01-8, the main research area is ketone preparation; carboxylic acid photoreductive cross coupling nickel; carboxylic acids; ketones; nickel; photocatalysis; radicals.

A simple visible light photochem., nickel-catalyzed synthesis of ketones from carboxylic acid-derived precursors is presented. Hantzsch ester (HE) functions as a cheap, green and strong photoreductant to facilitate radical generation and also engages in the Ni-catalytic cycle to restore the reactive species. With this dual role, HE allows for the coupling of a large variety of radicals (1°,2°, benzylic, α-oxy & α-amino) with aroyl and alkanoyl moieties, a new feature in reactions of this type. With both precursors deriving from abundant carboxylic acids, this protocol is a welcome addition to the organic chem. toolbox. The reaction proceeds under mild conditions without the need for toxic metal reagents or bases and shows a wide scope, including pharmaceuticals and complex mol. architectures.

Chemistry – A European Journal published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Qi Yukki published the artcileDecarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(II) carboxylates, Safety of 4-Methoxyphenylacetic acid, the main research area is carboxylic acid nucleophile decarboxylative cross coupling photo chem.

Reactions that enable carbon-nitrogen, carbon-oxygen and carbon-carbon bond formation lie at the heart of synthetic chem. However, substrate prefunctionalization is often needed to effect such transformations without forcing reaction conditions. The development of direct coupling methods for abundant feedstock chems. is therefore highly desirable for the rapid construction of complex mol. scaffolds. Herein, a copper-mediated, net-oxidative decarboxylative coupling of carboxylic acids with diverse nucleophiles under visible-light irradn is reported. Preliminary mechanistic studies suggest that the relevant chromophore in this reaction is a Cu(II) carboxylate species assembled in situ. Authors propose that visible-light excitation to a ligand-to-metal charge transfer (LMCT) state results in a radical decarboxylation process that initiates the oxidative cross-coupling. The reaction is applicable to a wide variety of coupling partners, including complex drug mols., suggesting that this strategy for cross-nucleophile coupling would facilitate rapid compound library synthesis for the discovery of new pharmaceutical agents.

Nature Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Safety of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lu, Dong published the artcileCopper-Catalyzed Regioselective Olefination and Trifluoromethylation of Carboxylic Acids To Give (Z)-Trifluoromethyl Enol Esters, Formula: C9H10O3, the main research area is aryl carboxylic acid trifluoromethyl trimethylsilane copper catalyst olefination trifluoromethylation; trifluoromethyl trimethylsilane aryl ether copper catalyst olefination trifluoromethylation; trifluoromethylenol ester regioselective diastereoselective preparation.

A method to produce (Z)-trifluoromethyl enol esters via the olefination and trifluoromethylation of carboxylic acids with TMSCF3 was reported. This synthetic method used inexpensive and easy-to-handle TMSCF3. It employed a com. available CuCl catalyst to transform a broad range of carboxylic acids into versatile (Z)-trifluoromethyl enol esters with good regio- and stereoselectivity. This protocol allowed the concise synthesis of highly functionalized (Z)-trifluoromethyl enol esters directly from carboxylic acids.

Organic Letters published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem