Grell, Yvonne published the artcileEnantioselective α-Fluorination and α-Chlorination of N-Acyl Pyrazoles Catalyzed by a Non-C2-Symmetric Chiral-at-Rhodium Catalyst, Application In Synthesis of 104-01-8, the main research area is chiral rhodium catalyst preparation; fluorinated alpha chlorinated acyl pyrazole enantioselective preparation; acyl pyrazole chiral rhodium catalyst fluorination chlorination.
A non-C2-sym. and sterically demanding chiral-at-rhodium catalyst was demonstrated to efficiently catalyze the highly enantioselective α-fluorination [up to >99% enantiomeric excess (ee)] and α-chlorination (up to 98% ee) of N-acyl pyrazoles to afford α-fluorinated/chlorinated N-acyl pyrazoles I [R = Pr, Ph, 3-thienyl, ets.; R1 = F, Cl] in high yields. Based on two sterically distinct cyclometalating ligands, the nonracemic rhodium(III) catalyst could conveniently be accessed in an enantiomerically pure fashion (>99% ee) via an established auxiliary-mediated approach. Comparison of the catalytic performance with the related C2-sym. rhodium catalysts revealed the explicit superiority of the non-C2-sym. design for the presented α-halogenation reactions, which were generally featured by a very simple synthetic protocol.
ACS Catalysis published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem