Tag: M.W=150-200

Garcia-Urricelqui, Ane published the artcilesyn-Selective Michael Reaction of α-Branched Aryl Acetaldehydes with Nitroolefins Promoted by Squaric Amino Acid Derived Bifunctional Broensted Bases, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is stereoselective Michael aryl acetaldehyde nitroolefin bifunctional cinchona squaric peptide.

Here we describe a direct access to 2,2,3-trisubstituted syn γ-nitroaldehydes by addition of α-branched aryl acetaldehydes to nitroolefins promoted by a cinchona based squaric acid-derived amino acid peptide. Different α-Me arylacetaldehydes react with β-aromatic and β-alkyl nitroolefins to afford the Michael adducts in high enantioselectivity and syn-selectivity. NMR experiments and DFT calculations predict the reaction to occur through the intermediacy of E-enolate. The interaction between the substrates and the catalyst follows Papai’s model, wherein an intramol. H-bond interaction in the catalyst between the NH group of one of the tert-leucines and the squaramide oxygen seems to be key for discrimination of the corresponding reaction transition states. Thus, e.g., 2-phenylpropanal + (E)-4-chloro-β-nitrostyrene → I (84%, 95:5 dr, 94% ee).

European Journal of Organic Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (γ-nitro). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Fiore, Ambra Maria published the artcileMild and efficient synthesis of secondary aromatic amines by one-pot stepwise reductive amination of arylaldehydes with nitroarenes promoted by reusable nickel nanoparticles, Name: 2,3-Dimethoxybenzaldehyde, the main research area is nitrobenzene aryl aldehyde polymer supported nickel reductive amination; secondary amine preparation.

The one-pot stepwise reductive amination of arylaldehydes with nitroarenes was described, using reusable nickel nanoparticles (Ni-pol) as catalyst and NaBH4 as mild, inexpensive and safe reducing agent. The proposed catalytic system holds several advantages such as the use of a non-precious and earth-abundant metal, the facile separation of the catalyst from the reaction mixture by centrifugation, excellent stability towards air and moisture, very mild reaction conditions, good recyclability, broad substrate scope with good to excellent yields and easy scalability. FESEM analyses indicate that the active species were cubic nanocrystals of Ni in the average cross section value of 35 nm with a quite narrow (25-45 nm) and monomodal distribution, which becomes bimodal with the recycling reactions but without agglomeration.

Molecular Catalysis published new progress about Aromatic nitro compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Name: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Martin, Ruben published the artcileAn Improved Protocol for the Pd-Catalyzed α-Arylation of Aldehydes with Aryl Halides, Synthetic Route of 1205-17-0, the main research area is aldehyde aryl bromide palladium catalyst alpha arylation; aryl chloride aldehyde palladium catalyst alpha arylation; alpha aryl aldehyde preparation; sporochnol preparation.

An improved protocol for the Pd-catalyzed α-arylation of aldehydes with aryl halides has been developed. The new catalytic system allows for the coupling of an array of substrates including challenging electron-rich aryl bromides and less reactive aryl chlorides. The utility of this method has been demonstrated in a new total synthesis of (±)-sporochnol.

Organic Letters published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (α-aryl). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Synthetic Route of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Schulz, Goeran published the artcileMetal free decarboxylative aminoxylation of carboxylic acids using a biphasic solvent system, Application of 4-Methoxyphenylacetic acid, the main research area is aromatic carboxylic acid aminoxyl radical decarboxylative aminoxylation; alkoxyamine preparation.

The smooth oxidative radical decarboxylation of carboxylic acids with TEMPO and other derivatives as radical scavengers was reported. The key to success was the use of a two-phase solvent system to avoid otherwise predominant side reactions such as the oxidation of TEMPO by persulfate and enabled the selective formation of synthetically useful alkoxyamines. The method does not require transition metals and was successfully used in a new synthetic approach for the antidepressant indatraline.

Organic & Biomolecular Chemistry published new progress about Alkoxylated amines Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Prabhala, Pavankumar published the artcileFacile one-pot synthetic access to libraries of diversely substituted 3-aryl (Alkyl)-coumarins using ionic liquid (IL) or conventional base/solvent, and an IL-mediated approach to novel coumarin-bearing diaryl-ethynes, Quality Control of 104-01-8, the main research area is aryl alkyl coumarin preparation; acetic acid aryl salicylaldehyde heterocyclization; coumarin diaryl ethyne preparation; arylethyne haloaryl coumarin Sonogashira reaction.

The in-situ formed carbonylimidazole derivatives of R1CH2COOH (R1 = CH3, 4-bromophenyl, naphthalen-1-yl, 3,4,5-trimethoxyphenyl, etc.) react at r.t. with substituted salicylaldehydes R2-2-OHC6H3CHO (R2 = H, 5-OMe, 4-Cl, 5-Br, etc.) in [BMIM][PF6] or [BMIM][BF4] as solvent, and [PAIM][NTf2] as basic-IL, to produce libraries of 3-aryl(alkyl)coumarins I (R2 = H, 6-OMe, 7-Cl, 6-Br, etc.). Whereas these reactions can also be performed with similar efficiency in THF by employing DBU and the IL approach offers easier work-up and recycling of the IL solvent. An IL-mediated approach to the synthesis of novel coumarin-bearing diaryl-ethynes II (R2 = H, 6-OMe; R3 = H, Me, CN, OMe, etc.) and III (R4 = N(CH3)2, CN) by the Sonogashira reaction is also reported, and the potential for recycling/reuse of the IL solvent is shown.

Tetrahedron Letters published new progress about Aliphatic acids Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Quality Control of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tvspv, Satya Guru published the artcileExcellent catalytic activity of ethylenediamine stabilised oxalate ligated aluminium coordination complex for synthesis of novel benzoquinolines, Quality Control of 86-51-1, the main research area is aluminum oxalate oxo complex preparation crystal structure heterocyclization catalyst.

Two-dimensional supramol. structure of oxalate ligated Al(III) coordination complex, (C2H10N2)2.[Al2(μ-O2)(oxalate)4]•2H2O (Al-Ox) was synthesized hydrothermally and determined the structural features with single-crystal x-ray diffraction studies. Unique oxo bridged dinuclear Al(III) clusters were established and each Al(III) atom bonded with two units of oxalate ligand. In the dinuclear Al(III) structure, two Al(III) atoms were separated with a bond distance of 2.8702 Å. Unsaturated metal centers creation upon activation acts as Lewis acid sites and ethylenediamine with a strong basic character in the structure remarkably facilitate an efficient and economic strategy for better organic transformations. The Lewis acid-base character catalytic efficacy of the complex is explored in the tandem multi-component synthesis of benzoquinoline-2-carbonitrile moieties. The synergy between the exceptional Lewis acidic and basic properties of Al-Ox contributed to its excellent catalytic activity in the generation of five new benzoquinoline-2-carbonitriles in impressive yields (92-96%) in short reaction time (∼15 min) in a simple one-pot protocol, in ethanol. Recyclability with consistent activity (>5 times) is the added advantage.

Polyhedron published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Quality Control of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xing, Ai-Ping published the artcileCuO-catalyzed conversion of arylacetic acids into aromatic nitriles with K4Fe(CN)6 as the nitrogen source, Application of 4-Methoxyphenylacetic acid, the main research area is aromatic nitrile preparation; arylacetic acid cyanation copper catalyst.

CuO was demonstrated to be effective as the catalyst for the conversion of arylacetic acids to aromatic nitriles ArCN [Ar = Ph, 2-MeC6H4, 1-naphthyl, etc.] with non-toxic and inexpensive K4Fe(CN)6 as the nitrogen source via the complete cleavage of the C≡N triple bond. The present method allowed a series of arylacetic acids including phenylacetic acids, naphthaleneacetic acids, 2-thiopheneacetic acid and 2-furanacetic acid to be converted into the targeted products in low to high yields.

Catalysis Communications published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chang, Meng-Yang published the artcileSynthesis of 1-Aryl Isoquinolinones or o-Diaryl Pyrimidines via Bismuth Triflate-Mediated Intermolecular Annulation of Arylacetic Acids with Nitroarylaldehydes or Trimethoxybenzene in the Presence of Acetonitrile, Synthetic Route of 104-01-8, the main research area is aryl isoquinolinone diaryl pyrimidine preparation; nitroarylaldehyde arylacetic acid trimethoxybenzene intermol multicomponent condensation bismuth triflate.

In this article, bismuth triflate (Bi(OTf)3)-controlled intermol. multi-component condensation of oxygenated arylacetic acids with electron-withdrawing nitroarylaldehydes or electron-donating trimethoxybenzene provide 1-aryl isoquinolinones or o-diaryl pyrimidines in acetonitrile at 60°C. The uses of various metal triflates and reaction conditions are investigated in the one-pot reaction. Only water is generated as the byproduct via (4C+1C+1N) and (2C+1N1C+1N1C) annulation routes. Plausible mechanisms have been proposed.

Advanced Synthesis & Catalysis published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (nitro). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yu, Lu published the artcileRegio- and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1,2-Diamines, Product Details of C9H10O3, the main research area is regioselective enantioselective hydroamination enamine diamine synthesis; amines; copper; enamines; enantioselectivity; hydroamination.

The asym. formal hydroamination of enamines using a CuH catalyst is reported [e.g., enamine I + O-acylhydroxylamine II → diamine III (69%, 97:3 e.r.) in presence of (MeO)2MeSiH as hydride source, Cu(OAc)2 and (R)-DTBM-SEGPHOS]. The method provides a straightforward and efficient approach to the synthesis of chiral 1,2-dialkyl amines in good yields with high levels of enantioselectivities for a broad range of substrates, and should have significant value for the preparation of mols. bearing a 1,2-diamine motif.

Angewandte Chemie, International Edition published new progress about Diamines Role: SPN (Synthetic Preparation), PREP (Preparation) (chiral). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Product Details of C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Li-Jun published the artcileVolatile components in three commercial douchies, a Chinese traditional salt-fermented soybean food, Application In Synthesis of 21834-92-4, the main research area is volatile compound douchi fermented soybean.

Douchi is a traditional fermented soybean product originated in China and it has been consumed since ancient times as seasoning for food. Volatile components of three com. douchies were extracted using a simultaneous steam distillation and extraction apparatus (SDE). The extracts were analyzed by gas chromatog.-mass spectrometry (GC-MS). A total of 131 compounds were identified, but only 25 components were common to all three brands. Major classes of compounds included esters (29), acids (18), alcs. (16), pyrazines (14), ketones (13), aldehydes (12), phenols (6), hydrocarbons (5), furans (5), sulfur-containing compounds (5), pyridines (4), pyrimidines (2), and miscellaneous compounds (2).

International Journal of Food Properties published new progress about Acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Application In Synthesis of 21834-92-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem