Chang, Meng-Yang published the artcileSynthesis of 1-Aryl Isoquinolinones or o-Diaryl Pyrimidines via Bismuth Triflate-Mediated Intermolecular Annulation of Arylacetic Acids with Nitroarylaldehydes or Trimethoxybenzene in the Presence of Acetonitrile, Synthetic Route of 104-01-8, the main research area is aryl isoquinolinone diaryl pyrimidine preparation; nitroarylaldehyde arylacetic acid trimethoxybenzene intermol multicomponent condensation bismuth triflate.
In this article, bismuth triflate (Bi(OTf)3)-controlled intermol. multi-component condensation of oxygenated arylacetic acids with electron-withdrawing nitroarylaldehydes or electron-donating trimethoxybenzene provide 1-aryl isoquinolinones or o-diaryl pyrimidines in acetonitrile at 60°C. The uses of various metal triflates and reaction conditions are investigated in the one-pot reaction. Only water is generated as the byproduct via (4C+1C+1N) and (2C+1N1C+1N1C) annulation routes. Plausible mechanisms have been proposed.
Advanced Synthesis & Catalysis published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (nitro). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem