Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84468-15-5,Isoquinoline-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.

b) 3-(5-Isoquinolinylsulfonyloxy)-5-methylphenol Orcinol monohydrate (1.42 g, 10.0 mmol) and 5-isoquinolinesulfonyl chloride (2.64 g, 10.0 mmol), as prepared in the preceding step, were mixed in saturated aqueous NaHCO3 (30 mL) and diethyl ether (30 mL). The biphasic mixture was stirred vigorously at ambient temperature overnight. The reaction mixture was diluted with water (50 mL) and extracted into ethyl acetate (3 x 50 mL). The organic phase was washed with brine (2 x 50 mL) and dried over Na2SO4. After removing the solvent in vacuo, the residue was triturated from ether / hexane to give the title compound as a pale yellow solid (1.15 g, 37%). 1H-NMR (300 MHz, CDCl3) delta 9.67 (s, 1H), 9.60 (s, 1 H), 8.86 (d, J = 6.1 Hz, 1H), 8.63 (d, J = 8.2 Hz, 1H); 8.37 (t, J = 6.1 Hz, 2H), 7.86 (t, J = 7.8 Hz, 1H), 6.46 (s, 1H), 6.23 (s, 1H), 5.97 (s, 1H), 2.08 (s, 3H)., 84468-15-5

84468-15-5 Isoquinoline-5-sulfonyl chloride 3371655, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Ortho-McNeil Pharmaceutical, Inc.; EP906091; (2006); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

891782-60-8,891782-60-8, 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

WXBB-2 (100.00 mg, 442.34 mumol, 1.00 eq), WX012-3 (110.00 mg, 900.38 mumol, 2.04 eq), cuprous iodide (43.00 mg, 225.78 mumol, 0.51 eq), 8-hydroxyquinoline (33.00 mg, 227.34 mumol, 39.29 muL, 0.51 eq), and potassium carbonate (92.00 mg, 665.65 mumol, 1.50 eq) were dissolved in dimethyl sulfoxide (15.00 mL), then purged with nitrogen three times, and the reaction was stirred at 130 C. for 16 hours. After the reaction was completed, the reaction solution was added with water (25 mL), and then extracted with dichloromethane (20 mL*3). The organic phases were combined, dried over anhydrous sodium sulfate (10 g), filtered and the filtrate was dried on a rotary evaporator. The obtained oil was separated and purified by Prep-TLC (ethyl acetate). Product WX012-4 was obtained, MSm/z: 268.1 [M+H]+.

891782-60-8 7-Bromo-3,4-dihydro-2H-isoquinolin-1-one 25067330, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; FUJIAN COSUNTER PHARMACEUTICAL CO., LTD.; Wu, Chengde; Yu, Tao; Li, Ning; Chen, Shuhui; US2019/375728; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215453-53-5,7-Bromoisoquinolin-1-amine,as a common compound, the synthetic route is as follows.

Example 1 (Compound No. 2 of table 1) 10-Bromo-2-pyridin-4-yl-4H-pyrimido[2,1-a]isoquinolin-4-one oxalate (1:1) ; To a mixture of 0.1g (0.38 mmol) of 7-bromoisoquinolin-1-amine (synthesis described in WO9847876) and 0.134g (0.69 mmol) of ethyl 3-(4-pyridinyl)-3-oxopropionate were added 0.059g (0.77 mmol) of ammonium acetate. The reaction mixture was heated at 140C for 12 hours. Then 2ml of Dowtherm A were added and the resulting mixture was allowed to stir at 210C for 8 hours. After cooling, water was added and the resulting solution was acidified using isopropanol hydrochloride 6N. Dowtherm A was extracted using diethyl ether and the aqueous phase was basified by an aqueous solution of sodium hydroxide (30%) and extracted with dichloromethane. The extracts were dried over sodium sulphate and evaporated. The residue obtained was purified by chromatography on silica gel eluting with a mixture of dichloromethane/methanol in the proportions 99/1 to 95/5 to give 0.041g (30%) of the desired compound which was transformed into the oxalate salt in the usual manner to give the pure product as a solid. MP: 244-246C RMN 1H (DMSO-d6; 200 MHz) delta (ppm) : 9.25 (s, 1H), 8.80 (d, 2H), 8.70 (d, 1H), 8.30 (d, 2H), 8.10 (dd, 1H), 8.00 (dd, 1H), 7.65 (d, 1H), 7.40 (s, 1H)., 215453-53-5

The synthetic route of 215453-53-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; sanofi-aventis; Mitsubishi Tanabe Pharma Corporation; EP2138495; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

51206-40-7, 1,4-Dibromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,51206-40-7

A mixture of 1.00 g, 3.49 mMol of 1,4-dibromoisoquinoline (Intermediate A) from step 1 and 4-chloroaniline were melted together at 140. The reaction mixture turned into a deep red liquid and after about 10 minutes the reaction mixture solidified and was done. The reaction mixture was broken up and triturated with a 50/50 methanol/THF mixture then filtered and air dried without further purification. wt. 0.75 g, 64.4%, mp.=260-263. Rf=0.58 in 40% ethyl acetate in hexanes.

As the paragraph descriping shows that 51206-40-7 is playing an increasingly important role.

Reference£º
Patent; BAYER CORPORATION; EP1228063; (2009); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1350643-72-9,(S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

To a suspension of 6-chloro-5-(2-methyl-2H-tetrazol-5-yl)pyrimidin-4-amine (30 mg, 0.142 mmol) and (S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one (44 mg, 0.149 mmol) in n-BuOH (3 mL) was added DIPEA (37 mg, 0.284 mmol). The resulted mixture was heated at reflux for 42 hours and monitored by TLC (PE/EtOAc, v/v, 1/3). The mixture was cooled to room temperature and concentrated in vacuo. The residue was diluted with EtOAc (15 mL), washed with water (15 mL) and brine (10 mL). The organic phase was dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a preparative TLC (PE/EtOAc (v/v)=1/4) to give the title compound as a pale yellow solid (35 mg, 52.1%). [0633] MS (ESI, pos, ion): 474.1 [M+H]+; HPLC: 91.4%; [0634] 1H NMR (400 MHz, CDCl3) delta (ppm): 8.79 (d, J=6.8 Hz, 1H), 8.01 (s, 1H), 7.56-7.32 (m, 8H), 6.58 (s, 1H), 5.11 (d, J=6.9 Hz, 1H), 4.52 (s, 3H), 1.53 (d, J=6.8 Hz, 3H)., 1350643-72-9

1350643-72-9 (S)-3-(1-Aminoethyl)-8-chloro-2-phenylisoquinolin-1(2H)-one 66607319, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; Xi, Ning; Wang, Liang; Wang, Tingjin; US2015/87658; (2015); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

201150-73-4, tert-Butyl 5-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step-1: Synthesis of tert-butyl 5-(2-ethyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-3,4-dihydroisoquinoline-2(1H)-carboxylate To a stirred solution of 2-ethyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one (200 mg, 0.58 mmol, 1.0 eq) in 5 mL of Toluene was added m-CPBA (250 mg, 1.45 mmol, 2.5 eq.) and allowed to stir at rt for 30 minutes. tert-butyl 5-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (140 mg, 0.58 mmol, 1.0 eq) and DIPEA (300 mg, 2.32 mmol, 4.0 eq) were added and allowed to stir at rt for 1 h. Progress of reaction was monitored by LCMS. After completion of reaction solvent was removed under reduced pressure, residue was diluted with 20 ml of water and extracted with ethyl acetate (50 mL*3). Combined organic layer was washed with water (20 ml*3), dried over anhydrous sodium sulfate and concentrated under reduced pressure. Crude was purified by flash chromatography to obtain 170 mg (53.79%) of tert-butyl 5-(2-ethyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)-3,4-dihydroisoquinoline-2(1H)-carboxylate., 201150-73-4

The synthetic route of 201150-73-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; Gupta, Ashu; KUMAR, Varun; (498 pag.)US2019/106427; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

147497-32-3, 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 29 Preparation of 2-(2-(1,3-dioxan-2-yl)ethyl)-6-bromo-3,4-dihydroisoquinolin-1(2H)-one A suspension of sodium hydride (60% dispersion in mineral oil, 0.54 g, 13.6 mmol) in DMF at room temperature, under nitrogen, was treated dropwise over 15 min with a solution of 6-bromo-3,4-dihydroisoquinolin-1(2H)-one (2.05 g, 9.1 mmol) in DMF, stirred at room temperature for 20 min, treated with 2-(2-bromoethyl)-1,3-dioxane (1.84 mL, 13.6 mmol), stirred for 16 h and partitioned between water and CH2Cl2. The aqueous phase was extracted with CH2Cl2. The combined organic phase and extracts were washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by ISCO CombiFlash chromatography (silica, 0-100% ethyl acetate in hexanes) to afford the title compound as a light yellow oil, 3.0 g (97%), MS (ES) m/z 340.1 [M+H]+., 147497-32-3

The synthetic route of 147497-32-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth; US2009/69300; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

34784-04-8, 5-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-Bromosuccinimide (17.8 g, 10 mmol) was added in portions to a solution of isoquinoline 1 (10.1 mL, 8.5 mmol) in concentrated H2SO4 (100 mL) at -10 C. The mixture was stirred for 2 h at 20 C, followed by the addition of KNO3 (11.2 g, 11.1 mmol) and standing at room temperature for 48 h. Then, the mixture was poured in ice and neutralized with saturated aqueous NH3, the precipitate formed was collected by filtration and recrystallized from MeOH. The yield was 14.2 g (65%).

34784-04-8, The synthetic route of 34784-04-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bastrakov; Starosotnikov; Russian Chemical Bulletin; vol. 68; 9; (2019); p. 1729 – 1734; Izv. Akad. Nauk, Ser. Khim.; 9; (2019); p. 1729 – 1734,6;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4721-98-6,6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline,as a common compound, the synthetic route is as follows.

EXAMPLE 6 Preparation of 1-[bis(hydroxymethyl)-methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline To 1 mole (205.3 g) of 1-methyl-6,7-dimethoxy-3,4-dihydroisoquinoline 100 ml of a 30% aqueous formaldehyde solution and then freshly prepared sodium methylate (1 g of sodium+50 ml of methanol) are added. The mixture is then slightly refluxed in 500 ml of methanol for 2 hours. The reaction mixture is evaporated under reduced pressure and the obtained crystalline product is recrystallized from a mixture of acetone and ether. The aimed compound is obtained with the same melting point as the product of Example 1.

4721-98-6, 4721-98-6 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline 22652, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Richter Gedeon Vegyeszeti Gyar R.T.; US4656179; (1987); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

74417-44-0, 1-(Bromomethyl)isoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,74417-44-0

1-(bromomethyl)isoquinoline (150 mg, 0.675 mmol) was dissolved in chloroform (15 mL) and cooled in water-ice bath m-chloroperoxobenzoic acid (77%, 0.230 g, 1.03 mmol) was added while stirring. The reaction mixture was let to gradually warm up to room temperature and stirred for 24 hours. The solvent was evaporated and the residue was purified by column chromatography on silica in methanol/ethyl acetate mixture. Fractions containing the product were evaporated to give 102 mg of product as pale yellow solid (0.430 mmol, 64 % yield relative to l-(bromomethyl)isoquinoline).’H NMR (CDC13, 25 C, 500 MHz): 5.17 (C//2-arom.. s, 2H); 7.61 ( arom ., ddd,1H,3/HH= 8 Hz,3/HH= 7 Hz,4/HH= 1 Hz); 7.64 (arom., d, 1H,3/HH = 7 Hz); 7.73(arom., ddd, 1H,3/HH = 9 Hz,3/HH = 7 Hz,4/HH = 1 Hz); 7.80-7.83 (arom., m, 1H);7.95 (arom., ddd, 1H,3/HH= 9 Hz,4/HH= 2 Hz,4/HH= 1 Hz); 8.19 (arom., d, 1H,3/HHNMR (CDC13, 25 C, 125 MHz): 5C20.9 (C//2-arom., s); 122.9 (arom., s); 124.0 (arom., s); 127.6 (arom., s); 127.8 (arom., s); 128.6 (arom., s); 128.8 (arom., s); 129.9 (arom., s); 136.9 (arom., s); 143.1 (arom., s).HRMS (ESI) m/z: [(M + H)+] (Ci0H9BrNO) calculated: 237.9862, found: 237.9863

74417-44-0 1-(Bromomethyl)isoquinoline 2776246, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I.; POLASEK, Miloslav; (102 pag.)WO2019/106182; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem