147497-32-3, 6-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 29 Preparation of 2-(2-(1,3-dioxan-2-yl)ethyl)-6-bromo-3,4-dihydroisoquinolin-1(2H)-one A suspension of sodium hydride (60% dispersion in mineral oil, 0.54 g, 13.6 mmol) in DMF at room temperature, under nitrogen, was treated dropwise over 15 min with a solution of 6-bromo-3,4-dihydroisoquinolin-1(2H)-one (2.05 g, 9.1 mmol) in DMF, stirred at room temperature for 20 min, treated with 2-(2-bromoethyl)-1,3-dioxane (1.84 mL, 13.6 mmol), stirred for 16 h and partitioned between water and CH2Cl2. The aqueous phase was extracted with CH2Cl2. The combined organic phase and extracts were washed with brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by ISCO CombiFlash chromatography (silica, 0-100% ethyl acetate in hexanes) to afford the title compound as a light yellow oil, 3.0 g (97%), MS (ES) m/z 340.1 [M+H]+., 147497-32-3
The synthetic route of 147497-32-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Wyeth; US2009/69300; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem