With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4721-98-6,6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline,as a common compound, the synthetic route is as follows.
EXAMPLE 6 Preparation of 1-[bis(hydroxymethyl)-methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline To 1 mole (205.3 g) of 1-methyl-6,7-dimethoxy-3,4-dihydroisoquinoline 100 ml of a 30% aqueous formaldehyde solution and then freshly prepared sodium methylate (1 g of sodium+50 ml of methanol) are added. The mixture is then slightly refluxed in 500 ml of methanol for 2 hours. The reaction mixture is evaporated under reduced pressure and the obtained crystalline product is recrystallized from a mixture of acetone and ether. The aimed compound is obtained with the same melting point as the product of Example 1.
4721-98-6, 4721-98-6 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline 22652, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; Richter Gedeon Vegyeszeti Gyar R.T.; US4656179; (1987); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem