Tag: M.W:200-300

58142-99-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58142-99-7,5-Iodoisoquinoline,as a common compound, the synthetic route is as follows.

Dissolve (trans)-4-methylhexahydropyrrole[3,4-b][1,4]oxazine (333 mg, 2.3 mmol) in toluene (20 mL)Add triethylamine (2 mL), 5-iodoisoquinoline (718 mg, 2.8 mmol), XPhos (110 mg, 0.23 mmol), cesium carbonate (2.25 g, 6.9 mmol) and palladium acetate (52 mg) successively. , 0.23 mmol), heated to 90C under nitrogen atmosphere overnight. The mixture was filtered off with suction and the filtrate was concentrated and purified by column chromatography to give the title compound (600 mg).

The synthetic route of 58142-99-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Liu Gang; Wu Yongyong; Yu Hua; Wang Kunjian; Li Xiaoyong; Sun Ling; Wang Runjiang; Chen Qiangqiang; Yang Long; Song Hongmei; Zeng Hong; Zhang Hong; Ye Qijun; Wang Lichun; Wang Jingyi; (98 pag.)CN107540659; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27655-40-9,Isoquinoline-5-sulfonic acid,as a common compound, the synthetic route is as follows.

The solution of isoquinoline-5-sulfonic acid 1b (4.0 g, 0.019 mol) in 25 mL thionyl chloride and 0.1 mL dimethylformamide was heated to reflux for 2 h. The mixture was then distilled under reduced pressure to remove unreacted thionyl chloide. The crude was washed by dichloromethane (10 mL*2), and air dried to give isoquinoline-5-sulfonyl chloride 1e (3.9 g, yellow solid, yield: 100%). MS-ESI cal. [M+H]+ 227, found 227., 27655-40-9

27655-40-9 Isoquinoline-5-sulfonic acid 241599, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; MEDSHINE DISCOVERY INC.; WU, Lingyun; YAO, Yuanshan; CHEN, Zhaoguo; CHEN, Shuhui; (69 pag.)US2017/37050; (2017); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

164148-92-9, tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(lH)-carboxylate (99.3 mg,0.4 mmol) and mesylate 27c (123 mg, 0.4 mmol) were dissolved in MeCN (1 mL). Cs2CO3 (261 mg, 0.8 mmol) was added and the mixture was stirred at 9O0C overnight. The mixture was then diluted with MeCN and filtered. The filtrate was purified by reverse-phase HPLC to yield the title compound (Example 29). 1H-NMR (400 MHz, CD3CN) delta = 7.04 (d, J = 8.4 Hz, IH), 6.81 (dd, J = 8.4, 2.4 Hz, IH), 6.76 (s, IH), 4.83 (septet, J = 6.4 Hz, IH), 4.47 (s, 2H), 4.04 (br. d, J = 13.2 Hz, 2H), 3.58 (t, / = 6.0 Hz, 2H), 3.15 (t, J = 7.6 Hz, 2H), 2.76 (t, J = 6.0 Hz, 2H), 2.76-2.68 (m, 2H), 1.69-1.61 (m, 4H), 1.47 (s, 9H), 1.47-1.40 (m, IH), 1.34-1.28 (m, 2H), 1.21 (d, J = 6.4 Hz, 6H), 1.02 (ddd, J = 12.8, 12.4, 4.0 Hz, 2H); MS calcd. for [M+2H-Boc]+ C21H34N3O2: 360.2; found: 360.1.

164148-92-9, The synthetic route of 164148-92-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IRM LLC; WO2008/97428; (2008); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.164148-92-9,tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of 1 ,1-dimethylethyl 6-amino-3,4-dihydro-2(1 H)-isoquinolinecarboxylate (9.5 g, 38.3 mmol.) in THF (350 ml_) under nitrogen and cooled to 00C were added sodium hydrogenocarbonate (8 g, 95.6 mmol.) and after 2 to 3 minutes of stirring, drop-wise, a solution of chloroacetyl chloride (6.1 ml, 76.5 mmol.) in THF (10 ml_). The mixture was stirred at O0C for 10 minutes then heated up to room temperature and stirred for 2.5 hours. The mixture was poured into an aqueous saturated solution of sodium hydrogenocarbonate and ethyl acetate (500ml) was added. The organic layer was washed three times with aqueous saturated solution of sodium hydrogenocarbonate then dried on sodium sulphate, filtered and evaporated to dryness to give the title compound as yellow oil which crystallised slowly (14.09 g, quantitative yield).1H NMR (400 MHz, DMSO, ppm) delta: 10.2 (bs, 1 H), 7.44 (bs, 1 H), 7.36 (bd, 1 H), 7.12 (d, 1 H), 4.45 (m, 2H), 4.23 (s, 2H), 3.54 (t, 2H), 2.75 (t, 2H), 1.43 (s, 9H).

164148-92-9, As the paragraph descriping shows that 164148-92-9 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/104524; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51206-40-7,1,4-Dibromoisoquinoline,as a common compound, the synthetic route is as follows.,51206-40-7

Dibromoisoquinoline (5, 29 mg, 0.1 mmol) Example 1, step 1, and M-NH2 (0.2 mmol) in 8-mL vial were heated in 1 mL of n-butanol at 90 C. for 36 hrs. The mixture was cooled to room temperature and the solvent was evaporated under reduced pressure. 4-Mercaptopyridine (23 mg, 0.2 mmol) and cesium carbonate (67 mg, 0.2 mmol) were added to the vial. The mixture was heated at 180 C. for 1 hr and was allowed to cool to room temperature. Methanol (2 mL) was added to the vial and the mixture was sonicated for 10 min and filtered. The methanol solution of reaction mixture was collected and evaporated under reduced pressure. The formation of product was confirmed by LC/MS. The invention compounds of Examples 83-92 as shown in the below table were prepared by method B-1.

51206-40-7 1,4-Dibromoisoquinoline 640981, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Pharmaceuticals Corporation; US6689883; (2004); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1109230-25-2, 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[001081 A mixture of 5-bromo-3,4-dihydro-2H-isoquinolin-1-one (Preparation 3-1, 4.3 g, 18.9 mmol) and 2,3-dicyano-5,6-dichloro-1,4-benzoquinone (8.6 g, 37.9 mmol) in 1,4-dioxane (76 mL) was stirred at 100 C for 24 h. The reaction mixture was evaporated and the residue was taken up in ethyl acetate (500 mL) and washed with 10% aqueous sodium hydroxide (2 x 500 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (4 x 300 mL). The combined organic layers were dried over sodium sulfate, evaporated and purified by flash chromatography eluting with dichloromethane:methanol (99:1 -96:4) to give the title compound (1.49 g, 6.65 mmol, 35%) as a yellow solid. LCMS: 94%, Rt 1.243, ESMS m/z 224 (M+H)., 1109230-25-2

The synthetic route of 1109230-25-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOST’YU “PANACELA LABS”; GUROVA, Katerina; RYDKINA, Elena Borisovna; WADE, Warren; WO2015/50471; (2015); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.82827-09-6,6-Bromoisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

82827-09-6, 6-Bromoisoquinoline-1 (2Eta)-one (12mm0l), bis(4-methoxyphenyl)disulfide (10mmol), hexafluorofluoride was sequentially added to the pressure resistant reaction tube at room temperature. Silver acid (10 mmol) and dichloroethene (6 mL) were applied. Then the reaction mixture is at 90 C Reaction for 10 hours. The reaction was stopped, concentrated under reduced pressure to give a crude material, which was washed with a mixture of petroleum ether and ethyl acetate. 4-(4-Methoxyphenylthio)-6-bromoisoquinoline-1 (2H)-one. Yield 95%;

The synthetic route of 82827-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nankai University; Zhu Youquan; He Jingli; Niu Yunxia; Han Tingfeng; Li Haoyu; (14 pag.)CN108822035; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

82827-09-6,82827-09-6, 6-Bromoisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

C. 6-Bromo-1-Chloroisoquinoline 6-Bromoisoquinolin-1-one (2.54 g, 11 mmol) is converted to the title compound (2.69 g, 11 mmol) by the method described in EXAMPLE 23, Part C. 1 H NMR (CDCl3, 300 MHz) delta8.30 (d, 1H), 8.19 (d, 1H), 8.04 (s, 1H), 7.78 (d, 1H), 7.52 (d, 1H), 7.27 (s, 1H), 6.49 (d, 1H). EI MS, M+ =241, 243.

The synthetic route of 82827-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Rhone-Poulenc Rorer Pharmaceuticals Inc.; US5731315; (1998); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.

Reference Preparation Example Homopiperazine (3.413 g) was dissolved in tetrahydrofuran (57 ml) with stirring. After cooling the solution to -5 C, 5-isoquinolinesulfonyl chloride hydrochloride (3.00 g) was added while maintaining the intemal temperature at 10 C or less. The mixture was stirred at 5 C or less for four hours. The reaction mixture was allowed to stand to reach room temperature and filtered to remove insoluble matter. The filtrate was concentrated under reduced pressure, followed by the addition of ethyl acetate (57 ml), water (17 ml), and 3 N hydrochloric acid aqueous solution (6.4 ml). The mixture was separated into layers to obtain a water layer. After washing the water layer with ethyl acetate (7 ml), water (6 ml), ethyl acetate (57 ml), and 6 N sodium hydroxide aqueous solution (3 ml) were added to separate the mixture into layers and obtain an organic layer. The organic layer was concentrated under reduced pressure and the residue was dried under reduced pressure to obtain fasudil (1.36 g). The yield was 41%. The fasudil is processed by the method described in JP-A-9-71582 to obtain fasudil hydrochloride. Fasudil can also be obtained in the same manner using the solvents listed below instead of tetrahydrofuran used in the Reference Preparation Example at yields described in the parentheses. Acetone (22%), acetonitrile (30%), 1,2-dimethoxyethane (31%), 2-butanone (24%), anisole (34%), isopropyl ether (10%), ethyl acetate (38%), toluene (18%), etc. Concentration of the filtrate was unnecessary when anisole, isopropyl ether, ethyl acetate, and toluene were used as the solvent., 105627-79-0

As the paragraph descriping shows that 105627-79-0 is playing an increasingly important role.

Reference£º
Patent; Asahi Kasei Pharma Corporation; EP1726306; (2006); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

679433-91-1, 5-Bromo-8-methoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,679433-91-1

To a mixture of l-bromo-5-methoxynaphthalene1 (320 mg, 1.3 mmol) and 4-aminophenylboronic acid (HCl salt, 320 mg, 1.85 mmol) in dioxane (3 mL)-H20 (3 mL) was added PdCl2(dppf)-dichloromethane (53 mg, 0.063 mmol) and Na2CO3 (530 mg, 4.2 mmol). The mixture was heated to 1000C for 12 h and cooled to room temperature. The mixture was extracted with dichloromethane and the organic phase was dried over Na2SO^ concentrated, and purified on silica with 5% (2N NH3 in MeOH) in dichloromethane to afford the product as a tan solid (300 mg, 89%). MS (ESI pos. ion) m/z: 251 (M+H).

As the paragraph descriping shows that 679433-91-1 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; WO2007/5668; (2007); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem