Day: November 14, 2022

Paul, Dipankar published the artcileA facile iron-catalyzed dual C-C bond cleavage: an approach towards triarylmethanes, HPLC of Formula: 151-10-0, the main research area is triarylmethane preparation; benzyl substituted diketone nucleophile dual bond cleavage iron catalyst.

A facile iron-catalyzed dual C-C bond cleaving reaction involving 1,3-dicarbonyl units along with electron-rich and sterically bulky arenes as efficient carbon-based leaving groups was developed. The scope of the dual C-C bond breaking reaction was studied in detail using a range of nucleophiles to synthesize sym. triarylmethanes in good to excellent yields. The intermediate of the reaction was isolated which was formed via the initial Csp3-Csp3 bond cleavage and subsequently converted the intermediate to the final product via the Csp3-Csp2 bond cleavage. A notable difference in the leaving aptitudes of the two carbon-based leaving groups perceived during the study enabled us to develop an application of the dual C-C bond breaking reaction for the synthesis of unsym. triarylmethanes in a stepwise manner. To improve the synthetic utility, a one-pot procedure to generate unsym. triarylmethanes via sequential C-C bond breaking reactions were also fashioned . In addition to studying a novel dual C-C bond breaking reaction and providing a hint to the mechanistic pathway, the application molded from the study for the synthesis of sym. and especially unsym. triarylmethanes may render value to the present work.

New Journal of Chemistry published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sarma, Daisy published the artcileVisible-light induced enhancement in the multi-catalytic activity of sulfated carbon dots for aerobic carbon-carbon bond formation, Formula: C8H10O2, the main research area is sulfated carbon dot aerobic bond formation photocatalyst visible light; xanthene ketone arene dicarbonyl dehydrogenative cross coupling visible light.

The development of carbonaceous materials as metal-free catalysts integrating different types of catalysis in a single system represents a significant advance in cascade/tandem organic synthesis. Zero-dimensional carbon dots with tuneable optical properties and easily modifiable surface functionalities can be harnessed as a carbocatalyst for merging photooxidation and acid-catalyzed reactions in one pot. Herein, we explore carbon dots decorated with hydrogen sulfate groups as a photocatalyst for the dehydrogenative cross-coupling of xanthenes with ketones, arenes and 1,3-dicarbonyl compounds that showed high efficiency and selectivity under visible-light irradiation The sulfated carbon dots demonstrate dual catalytic properties, wherein they induced the rapid photooxidation of xanthenes in the presence of mol. oxygen to form a hydroperoxy intermediate followed by coupling of nucleophiles catalyzed by the acidic surface functional groups. The methodol. represents an operationally simple pathway for the generation of C-C coupling products in a short reaction time with wide substrate scopes under mild conditions. The catalyst is easily separable and can be reused over multiple cycles with good efficiency.

Green Chemistry published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Verma, Vibha published the artcileQuinolinium chlorochromate: an excellent reagent for N3-C4 dehydrogenation of dihydropyrimidinones and their antifungal evaluation, SDS of cas: 598-50-5, the main research area is pyrimidinone green preparation antifungal SAR; dihydropyrimidinone preparation antifungal SAR oxidation quinolinium chlorochromate; benzaldehyde ketoester urea Biginelli hydrochloric acid catalyst.

3,4-Dihydropyrimidin-2-ones (DHPMs) I [R1 = Ph, 3-HOC6H4, 2-O2NC6H4, etc.; R2 = Me, Et, i-Pr; R3 = H, Me] were synthesized by reaction of aromatic aldehydes, β-ketoester and urea/N-Me urea. These compounds I on oxidation with quinolinium chlorochromate as an oxidizing agent resulted into pyrimidin-2-ones II. The synthesized compounds I and II were screened against three test fungi of wheat crop, i.e., Alternaria triticina, Bipolaris sorokiniana and Ustilago segetum tritici by spore germination method. Compounds II showed excellent antifungal activity than compounds I with least ED50 values 42, 93 and 47 μg/mL. Among the tested compounds, compounds II [R1 = 4-O2NC6H4, R2 = i-Pr, R3 = H; R1 = 2,4-di-MeOC6H3, R2 = Et, R3 = Me] were found to be most active. Structure activity relationship showed that electron withdrawing group enhanced their efficacy due to +I effect and vice versa, whereas dehydrogenation improved their potential due to resonance stabilization of structures involved during electronic interactions between proteins of fungus cells and compounds

Indian Journal of Heterocyclic Chemistry published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, SDS of cas: 598-50-5.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Rahman, Taskia published the artcileSpinel Structured Copper Ferrite Nano Catalyst with Magnetic Recyclability for Oxidative Decarboxylation of Phenyl Acetic Acids, Related Products of isoquinoline, the main research area is copper ferrite catalyst oxidative decarboxylation phenyl acetic acid.

A simple, efficient and environmentally benign method has been discussed for the synthesis of aldehydes and ketones by the oxidative decarboxylation of phenylacetic acid under ligand free condition using simple, efficient, preparatively easy, magnetically recoverable and low cost spinel CuFe2O4 nanoparticles. The catalyst was characterized using powder-XRD, FTIR, FE-SEM, EDX, VSM and HRTEM. The recyclability was examined and the results showed that the catalyst remained almost equally active up to five consecutive cycles. Spinel Structured Copper Ferrite is a very efficient nano catalyst for Oxidative decarboxylation of Ph acetic acids and can be reused up to five cycles without significant loss in catalytic activity.

Catalysis Letters published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shen, Zhenpeng published the artcileIron-Promoted Decarboxylation of Arylacetic Acids for the Synthesis of Aromatic Nitriles with Sodium Nitrite as the Nitrogen Source, Product Details of C9H10O3, the main research area is aromatic nitrile preparation; arylacetic acid decarboxylation iron catalyst.

A new and effective method was developed for the synthesis of aromatic nitriles ArCN (Ar = 4-chlorophenyl, naphthalen-1-yl, thiophen-2-yl, etc.) (I) from arylacetic acids ArCH2C(O)OH (II) by using NaNO2 as the nitrogen source and Fe(OTf)3 as the promoter at 50°C. A series of arylacetic acids II underwent this transformation to give the targeted products I in yields of 51-90%. Because of the mild conditions, the reaction is compatible with a broad range of functional groups, including ester, carboxy, hydroxy, acetamido, halo, nitro, cyano, methoxy, and even highly reactive formyl groups.

Synlett published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Product Details of C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Meszaros, Rebeka published the artcileExploiting a silver-bismuth hybrid material as heterogeneous noble metal catalyst for decarboxylations and decarboxylative deuterations of carboxylic acids under batch and continuous flow conditions, Application of 1,3-Dimethoxybenzene, the main research area is silver bismuth hybrid material catalyst preparation crystallinity; aromatic carboxylic acid silver bismuth hybrid material catalyst decarboxylation; deutero aromaticcarboxylic acid silver bismuth hybrid material catalyst deuterativedecarboxylation.

A novel catalytic methodologies for protodecarboxylations and decarboxylative deuterations of carboxylic acids utilizing a silver-containing hybrid material as a heterogeneous noble metal catalyst were reported. After an initial batch method development, a chem. intensified continuous flow process was established in a simple packed-bed system which enabled gram-scale protodecarboxlyations without detectable structural degradation of the catalyst. The scope and applicability of the batch and flow processes were demonstrated through decarboxylations of a diverse set of aromatic carboxylic acids. Catalytic decarboxylative deuterations were achieved on the basis of the reaction conditions developed for the protodecarboxylations using D2O as a readily available deuterium source.

Green Chemistry published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Maddila, Surya Narayana published the artcileAn eco-friendly approach for synthesis of novel substituted 4H-chromenes in aqueous ethanol under ultra-sonication with 94% atom economy, Quality Control of 86-51-1, the main research area is chromene preparation ultrasonication green chem; aryl aldehyde active methylene compound dimedone three component cyclization.

An operational approach for synthesis of eleven substituted 4H-chromene derivatives I (R = 2-CH3OC6H4, 4-CF3C6H4, pyridin-3-yl, etc.; R1 = Me, Et) by one-pot, three-component reaction of aromatic aldehydes RCHO, Me/Et cyanoacetate and 5,5 di-Me 1,3-cyclohexadione through ultrasound irradiation, in the presence of aqueous ethanol under catalyst-free condition is reported. Different spectral methods, including 1H, 13C and 15N NMR and HRMS were utilized to characterize the new mols. Benefits of the eco-friendly method are fast reaction (10 min), excellent yields (92-98%), no column chromatog. and no byproducts. Reaction offers 94% atom economy and 100% carbon capture.

Journal of Molecular Structure published new progress about Aryl aldehydes, heteroaryl Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Quality Control of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mastuo, Kasumi published the artcileNickel-Catalyzed Hydrodeoxygenation of Aryl Sulfamates with Alcohols as Mild Reducing Agents, Application In Synthesis of 151-10-0, the main research area is aromatic hydrocarbon preparation; aryl sulfamate hydrodeoxygenation nickel catalyst.

The nickel-catalyzed hydrodeoxygenation of aryl sulfamates ROS(O)2R1 [R = 2-propanoylbenzen-1-yl, 1-ethyl-1H-indol-4-yl, 4-(4-acetylpiperazin-1-yl)benzen-1-yl, etc.; R1 = dimethylaminyl, piperidin-1-yl, bis(propan-2-yl)aminyl, etc.] has been developed with alcs. as mild reductants. A variety of functional groups and heterocycles were tolerated in this reaction system to give the desired products RH in high yields. In addition, the gram-scale process and stepwise cine-substitution were also achieved with high efficiency.

Synthesis published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shi, Jiale published the artcileMetal-Free Heterogeneous Semiconductor for Visible-Light Photocatalytic Decarboxylation of Carboxylic Acids, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is aliphatic hetero aromatic arene preparation; hetero aromatic aliphatic acid hydrodecarboxylation photocatalyst; deuteride aliphatic hetero aromatic arene preparation; aromatic hetero aliphatic acid decarboxylative deuteration photocatalyst; diaryl methane preparation; carboxylic acid hetero aryl cyanide decarboxylative arylation photocatalyst.

A suitable protocol for the photocatalytic decarboxylation of carboxylic acids RC(O)OH (R = 3,5-dimethylphenyl, 2-(4-methylphenyl)ethyl, diphenylmethyl, isoquinolin-1-yl, etc.) was developed with metal-free ceramic boron carbon nitrides (BCN). With visible light irradiation, BCN oxidizes carboxylic acids to give carbon-centered radicals, which were trapped by hydrogen atom donors or employed in the construction of the carbon-carbon bond. In this system, both (hetero)aromatic and aliphatic acids proceed through the decarboxylation smoothly; and C-H, C-D, and C-C bonds are formed in moderate to high yields (35 examples, yield up to 93%). Control experiments support a radical process, and isotopic experiments show that methanol is employed as the hydrogen atom donor. Recycling tests and a gram-scale reaction elucidate the practicability of the heterogeneous ceramic BCN photoredox system. It provides an alternative to homogeneous catalysts in the valuable carbon radical intermediates formation. Moreover, the metal-free system is also applicable to late-stage functionalization of anti-inflammatory drugs, such as naproxen and ibuprofen, which enrich the chem. toolbox.

ACS Catalysis published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shi, Jiale published the artcileMetal-Free Heterogeneous Semiconductor for Visible-Light Photocatalytic Decarboxylation of Carboxylic Acids, Application In Synthesis of 151-10-0, the main research area is aliphatic hetero aromatic arene preparation; hetero aromatic aliphatic acid hydrodecarboxylation photocatalyst; deuteride aliphatic hetero aromatic arene preparation; aromatic hetero aliphatic acid decarboxylative deuteration photocatalyst; diaryl methane preparation; carboxylic acid hetero aryl cyanide decarboxylative arylation photocatalyst.

A suitable protocol for the photocatalytic decarboxylation of carboxylic acids RC(O)OH (R = 3,5-dimethylphenyl, 2-(4-methylphenyl)ethyl, diphenylmethyl, isoquinolin-1-yl, etc.) was developed with metal-free ceramic boron carbon nitrides (BCN). With visible light irradiation, BCN oxidizes carboxylic acids to give carbon-centered radicals, which were trapped by hydrogen atom donors or employed in the construction of the carbon-carbon bond. In this system, both (hetero)aromatic and aliphatic acids proceed through the decarboxylation smoothly; and C-H, C-D, and C-C bonds are formed in moderate to high yields (35 examples, yield up to 93%). Control experiments support a radical process, and isotopic experiments show that methanol is employed as the hydrogen atom donor. Recycling tests and a gram-scale reaction elucidate the practicability of the heterogeneous ceramic BCN photoredox system. It provides an alternative to homogeneous catalysts in the valuable carbon radical intermediates formation. Moreover, the metal-free system is also applicable to late-stage functionalization of anti-inflammatory drugs, such as naproxen and ibuprofen, which enrich the chem. toolbox.

ACS Catalysis published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem