Verma, Vibha published the artcileQuinolinium chlorochromate: an excellent reagent for N3-C4 dehydrogenation of dihydropyrimidinones and their antifungal evaluation, SDS of cas: 598-50-5, the main research area is pyrimidinone green preparation antifungal SAR; dihydropyrimidinone preparation antifungal SAR oxidation quinolinium chlorochromate; benzaldehyde ketoester urea Biginelli hydrochloric acid catalyst.
3,4-Dihydropyrimidin-2-ones (DHPMs) I [R1 = Ph, 3-HOC6H4, 2-O2NC6H4, etc.; R2 = Me, Et, i-Pr; R3 = H, Me] were synthesized by reaction of aromatic aldehydes, β-ketoester and urea/N-Me urea. These compounds I on oxidation with quinolinium chlorochromate as an oxidizing agent resulted into pyrimidin-2-ones II. The synthesized compounds I and II were screened against three test fungi of wheat crop, i.e., Alternaria triticina, Bipolaris sorokiniana and Ustilago segetum tritici by spore germination method. Compounds II showed excellent antifungal activity than compounds I with least ED50 values 42, 93 and 47 μg/mL. Among the tested compounds, compounds II [R1 = 4-O2NC6H4, R2 = i-Pr, R3 = H; R1 = 2,4-di-MeOC6H3, R2 = Et, R3 = Me] were found to be most active. Structure activity relationship showed that electron withdrawing group enhanced their efficacy due to +I effect and vice versa, whereas dehydrogenation improved their potential due to resonance stabilization of structures involved during electronic interactions between proteins of fungus cells and compounds
Indian Journal of Heterocyclic Chemistry published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, SDS of cas: 598-50-5.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem