Day: November 15, 2022

Yamamoto, Yoshihiko published the artcileSynthesis of difluoromethylated diarylmethanes via Fe(OTf)3-catalyzed Friedel-Crafts reaction of 2,2-difluoro-1-arylethyl phosphates, Application of 1,3-Dimethoxybenzene, the main research area is difluoromethylated diarylmethane preparation; difluoro arylethyl phosphate Friedel Crafts reaction.

The Fe(OTf)3-catalyzed Friedel-Crafts reaction of 2,2-difluoro-1-arylethyl phosphates with electron-rich (hetero)arenes afforded difluoromethylated diarylmethanes. Control experiments showed that Fe(OTf)3 behaves as the Lewis acid, and that the phosphate leaving group and o- or p-alkoxy substituents on the substrates are necessary for the Fe(OTf)3-catalyzed reaction to proceed under mild conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about Diketones, 1,3-diketones Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Fiore, Ambra Maria published the artcileMild and efficient synthesis of secondary aromatic amines by one-pot stepwise reductive amination of arylaldehydes with nitroarenes promoted by reusable nickel nanoparticles, Name: 2,3-Dimethoxybenzaldehyde, the main research area is nitrobenzene aryl aldehyde polymer supported nickel reductive amination; secondary amine preparation.

The one-pot stepwise reductive amination of arylaldehydes with nitroarenes was described, using reusable nickel nanoparticles (Ni-pol) as catalyst and NaBH4 as mild, inexpensive and safe reducing agent. The proposed catalytic system holds several advantages such as the use of a non-precious and earth-abundant metal, the facile separation of the catalyst from the reaction mixture by centrifugation, excellent stability towards air and moisture, very mild reaction conditions, good recyclability, broad substrate scope with good to excellent yields and easy scalability. FESEM analyses indicate that the active species were cubic nanocrystals of Ni in the average cross section value of 35 nm with a quite narrow (25-45 nm) and monomodal distribution, which becomes bimodal with the recycling reactions but without agglomeration.

Molecular Catalysis published new progress about Aromatic nitro compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Name: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ding, Wei published the artcileSite-selective aromatic C-H λ3-iodanation with a cyclic iodine(III) electrophile in solution and solid phases, SDS of cas: 151-10-0, the main research area is arylbenziodoxole site selective preparation; arene benziodoxole triflate site selective aromatic iodanation.

An efficient and site-selective aromatic C-H λ3-iodanation reaction was achieved using benziodoxole triflate (BXT) as an electrophile under room temperature conditions. The reaction tolerated a variety of electron-rich arenes and heteroarenes to afford the corresponding arylbenziodoxoles I [R = 4-OMeC6H4, 2,4-di-MeC6H3, 2-thienyl, etc.] in moderate to good yields. The reaction could also be performed mechanochem. by grinding a mixture of solid arenes and BXT under solvent-free conditions. The arylbenziodoxoles could be used for various C-C and C-heteroatom bond formations and are also amenable to further modification by electrophilic halogenation. DFT calculations suggested that the present reaction proceeded via a concerted λ3-iodanation-deprotonation transition state, where the triflate anion acts as an internal base.

Chemical Science published new progress about Alkadiynes Role: SPN (Synthetic Preparation), PREP (Preparation) (unsym.). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lan, Jin published the artcileOne-pot multi-component synthesis of N,O-acetal compounds catalyzed by D-proline at room temperature, Synthetic Route of 598-50-5, the main research area is benzaldehyde urea alkanol proline catalyst multicomponent reaction green chem; alkoxy benzylurea preparation.

A convenient method for multi-component one-pot synthesis of N,O-acetal compounds was developed using aromatic aldehydes, urea and alc. as starting materials and alc. was also used as solvent and D-proline as catalyst. A series of N,O-acetal compounds were synthesized in good yields after reacting for 30 h at room temperature

Youji Huaxue published new progress about Aliphatic alcohols, C1-4 Role: RCT (Reactant), RACT (Reactant or Reagent). 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, Synthetic Route of 598-50-5.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Garcia-Urricelqui, Ane published the artcilesyn-Selective Michael Reaction of α-Branched Aryl Acetaldehydes with Nitroolefins Promoted by Squaric Amino Acid Derived Bifunctional Broensted Bases, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is stereoselective Michael aryl acetaldehyde nitroolefin bifunctional cinchona squaric peptide.

Here we describe a direct access to 2,2,3-trisubstituted syn γ-nitroaldehydes by addition of α-branched aryl acetaldehydes to nitroolefins promoted by a cinchona based squaric acid-derived amino acid peptide. Different α-Me arylacetaldehydes react with β-aromatic and β-alkyl nitroolefins to afford the Michael adducts in high enantioselectivity and syn-selectivity. NMR experiments and DFT calculations predict the reaction to occur through the intermediacy of E-enolate. The interaction between the substrates and the catalyst follows Papai’s model, wherein an intramol. H-bond interaction in the catalyst between the NH group of one of the tert-leucines and the squaramide oxygen seems to be key for discrimination of the corresponding reaction transition states. Thus, e.g., 2-phenylpropanal + (E)-4-chloro-β-nitrostyrene → I (84%, 95:5 dr, 94% ee).

European Journal of Organic Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (γ-nitro). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem