Day: November 16, 2022

Shirase, Satoru published the artcileCerium(IV) Carboxylate Photocatalyst for Catalytic Radical Formation from Carboxylic Acids: Decarboxylative Oxygenation of Aliphatic Carboxylic Acids and Lactonization of Aromatic Carboxylic Acids, Name: 4-Methoxyphenylacetic acid, the main research area is aldehyde alc preparation; carboxylic acid decarboxylative oxygenation cerium carboxylate photocatalyst.

We found that in situ generated cerium(IV) carboxylate generated by mixing the precursor Ce(OtBu)4 with the corresponding carboxylic acids served as efficient photocatalysts for the direct formation of carboxyl radicals from carboxylic acids under blue light-emitting diodes (blue LEDs) irradiation and air, resulting in catalytic decarboxylative oxygenation of aliphatic carboxylic acids to give C-O bond-forming products such as aldehydes and ketones. Control experiments revealed that hexanuclear Ce(IV) carboxylate clusters initially formed in the reaction mixture and the ligand-to-metal charge transfer nature of the Ce(IV) carboxylate clusters was responsible for the high catalytic performance to transform the carboxylate ligands to the carboxyl radical. In addition, the Ce(IV) carboxylate cluster catalyzed direct lactonization of 2-isopropylbenzoic acid to produce the corresponding peroxy lactone and γ-lactone via intramol. 1,5-hydrogen atom transfer (1,5-HAT).

Journal of the American Chemical Society published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pedersen, Samuel K. published the artcileMain element chemistry enables gas-cylinder-free hydroformylations, Application In Synthesis of 1205-17-0, the main research area is alkene syngas hydroformylation main element chem.

Industrially, aldehydes are produced annually on a multimillion-tonne scale via the hydroformylation of olefins with syngas (CO/H2 mixture). Nonetheless, this transformation has not found frequent use in the laboratory Here, a simple strategy for the concerted generation of syngas from two accessible and crystalline main element compounds with just water as the primary activator for syngas release is reported. By decoupling the syngas formation and consumption via a two-chamber reactor, this low-pressure, low-temperature and near-stoichiometric hydroformylation operates efficiently on a diverse array of terminal olefins without the need for expensive equipment. This approach provides unique opportunities to access aldehydes in a safe and reliable manner with further adaptation to the synthesis of a range of pharmaceuticals and relevant mols. thereof. This strategy is adaptable to carbon isotope labeling as demonstrated by the use of a 13CO releasing mol. It’s anticipated that this hydroformylation approach will provide a complementary toolbox for drug discovery and development.

Nature Catalysis published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Glatz, Mathias published the artcileChemoselective Hydrogenation of Aldehydes under Mild, Base-Free Conditions: Manganese Outperforms Rhenium, Application In Synthesis of 1205-17-0, the main research area is hydride manganese rhenium pincer complex catalyst chemoselective hydrogenation aldehyde; alc preparation.

Several hydride Mn(I) and Re(I) PNP pincer complexes were applied as catalysts for the homogeneous chemoselective hydrogenation of aldehydes. Among these, [Mn(PNP-iPr)(CO)2(H)] was found to be one of the most efficient base metal catalysts for this process and represents a rare example which permits the selective hydrogenation of aldehydes in the presence of ketones and other reducible functionalities, such as C=C double bonds, esters or nitriles. The reaction proceeds at room temperature under base-free conditions with catalyst loadings between 0.1 and 0.05 mol% and a hydrogen pressure of 50 bar (reaching TONs of up to 2000). A mechanism which involves an outer-sphere hydride transfer and reversible PNP ligand deprotonation/protonation is proposed. Analogous isoelectronic and isostructural Re(I) complexes were only poorly active.

ACS Catalysis published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bruenig, Julian published the artcileChemoselective Supported Ionic-Liquid-Phase (SILP) Aldehyde Hydrogenation Catalyzed by an Fe(II) PNP Pincer Complex, Computed Properties of 1205-17-0, the main research area is alc preparation; aldehyde hydrogenation iron catalyst supported ionic liquid.

A base-tolerant supported ionic-liquid-phase (SILP) system containing a well-defined hydride Fe(II) PNP pincer complex has been prepared, structurally characterized, and used as catalyst in the hydrogenation of aldehydes to alcs. The new SILP catalyst, with the optimum pore filling, was highly active exhibiting TONs and TOFs of up to 1000 and 4000 h-1, resp., under mild conditions (25 °C, 10-50 bar H2 pressure) without significant leaching of both the complex and the IL.

ACS Catalysis published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Computed Properties of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Weber, Stefan published the artcileSelective Hydrogenation of Aldehydes Using a Well-Defined Fe(II) PNP Pincer Complex in Biphasic Medium, Related Products of isoquinoline, the main research area is aldehyde selective hydrogenation iron pincer complex catalyst ionic liquid; Hydrogenation; aldehydes iron; biphasic catalysis; ionic liquids; pincer complexes.

A biphasic process for the hydrogenation of aldehydes was developed using a well-defined iron (II) PNP pincer complex as model system to investigate the performance of various ionic liquids A number of suitable hydrophobic ionic liquids based on the N(Tf)2- anion were identified, allowing to immobilize the iron (II) catalyst in the ionic liquid layer and to facilitate the separation of the desired alcs. Further studies showed that targeted Bronsted basic ionic liquids can eliminate the need of an external base to activate the catalyst.

ChemCatChem published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ribeiro Gouveia, Liana published the artcileWell-Defined ENENES Re and Mn Complexes and Their Application in Catalysis: The Role of Potassium tert-Butoxide, Application In Synthesis of 86-51-1, the main research area is rhenium complex bidentate thienyldiamine ligand preparation catalyst aldehyde hydrogenation; manganese complex bidentate thienyldiamine ligand preparation catalyst aldehyde hydrogenation; crystal structure rhenium carbonyl complex bidentate thienyldiamine ligand; mol structure rhenium carbonyl complex bidentate thienyldiamine ligand.

A new family of air-stable Re and Mn complexes bearing bidentate NNS (ENENES) ligands E(CH2)2NH(CH)2SR (E = -NC4H8O or -NC5H10, R = Ph or thiophenyl) is introduced. All Re and Mn complexes were catalysts for the hydrogenation of aldehydes. The Mn catalysts were active at milder conditions. A Re-hydride complex, featuring cis Re-H and N-H moieties, was isolated to provide an insight into the mechanism for this reaction. DFT (B3PW91-D3) and probably there are two pathways for this system, with and without the presence of the base (t-BuOK). The pathway that included t-BuOK was lower in energy, providing a greater driving force for the overall reaction.

Organometallics published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application In Synthesis of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Harenberg, Johannes H. published the artcilePreparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow, Name: 1,3-Dimethoxybenzene, the main research area is metalation continuous flow generation organopotassium aromatic hetaryl nucleophile; electrophile addition coupling organopotassium aromatic heterocyclic compound; alc ketone thioether silane preparation organopotassium nucleophile addition coupling; arenes; flow chemistry; heteroarenes; lateral metalation; potassium.

Heterocyclic and aromatic compounds were metalated by lithium-free potassium diisopropylamide serving as nucleophiles in carbonyl group addition and coupling reactions, providing access to versatile substituted benzothiazoles, benzothiophenes, benzofurans and functionalized aromatic compounds We report the preparation of lithium-salt-free KDA (potassium diisopropylamide; 0.6 M in hexane) complexed with TMEDA (N,N,N’,N’-tetramethylethylenediamine) and its use for the flow-metalation of (hetero)arenes between -78° and 25° with reaction times between 0.2 s and 24 s and a combined flow rate of 10 mL min-1 using a com. flow setup. The resulting potassium organometallics react instantaneously with various electrophiles, such as ketones, aldehydes, alkyl and allylic halides, disulfides, Weinreb amides, and Me3SiCl, affording functionalized (hetero)arenes in high yields. This flow procedure is successfully extended to the lateral metalation of methyl-substituted arenes and heteroaromatics, resulting in the formation of various benzylic potassium organometallics. A metalation scale-up was possible without further optimization.

Angewandte Chemie, International Edition published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Salgin-Goksen, Umut published the artcileNew 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is benzoxazolinoneyl acetyl pyrazoline preparation monoamine oxidase ADMET human SAR; phenylallylidene benzoxazolinoneyl acetohydrazide preparation mol docking ADME antitumor.

Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3,5-disubstitutedphenyl-2-pyrazolines I [R1 = H, Me, Cl; R2 = H, 4-Me, 4-OMe, 2-OMe, 3-OMe; R3= H, 4-Me, 3-OMe, etc.] structure and nine compounds N’-(1,3-disubstitutedphenylallylidene)-2-(5-substituted-2-benzoxazolinone-3-yl)acetohydrazides II [R1 = H, Me, Cl; R2 = H, 2-OMe, 4-OMe, 2-OMe; R3 = H, 2-OMe, 3-OMe, 2-Cl, 2,3-di-OMe] were synthesized and evaluated as monoamine oxidase (MAO) inhibitors. All of the compounds I and II exhibited selective MAO-A inhibitor activity in the nanomolar or low micromolar range. The results of the mol. docking for hydranone derivatives II supported the in vitro results. Compounds, I [R1 = R2 = H, R3 = 4-Me] (0.008μM, selectivity index (SI): 9.70 x 10-4), I [R1 = R2 =H, R3 = 3,4-di-OMe] (0.009μM, SI: 4.55 x 10-5), I [R1 = H, R2 = 4-OMe, R3 = 2-Cl] (0.001μM, SI: 8.00 x 10-4), I [R1 = Me, R2 = 4-OMe, R3 = 2,3-di-OMe] (0.009μM, SI: 1.37 x 10-5) and II [R1= Cl, R2 = 4-OMe, R3 = 2,3-di-OMe] (0.010μM, SI: 5.40 x 10-6), exhibiting the highest inhibition and selectivity toward hMAO-A and nontoxic to hepatocytes were assessed for antidepressant activity as acute and subchronic in mice. All of these five compounds showed significant antidepressant activity with subchronic administration consistent with the increase in the brain serotonin levels and the compounds crossed the blood-brain barrier according to parallel artificial membrane permeation assay. Compounds I [R1 = H, Me, Cl; R2 = 4-OMe, R3 = 2-Cl, 2,3-di-OMe] exhibited an ex vivo MAO-A profile, which was highly consistent with the in vitro data.

Journal of Medicinal Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tank, Manishkumar J. published the artcileSynthesis and biological activities of Chalcone and Pyrimidine derivatives of imidazothiadiazole moiety, Application In Synthesis of 104-01-8, the main research area is imidazothiadiazolyl phenylpropenyl chromenone preparation antibacterial antifungal antitubercular antimalarial activity; pyrimidinyl imidazothiadiazolyl chromenone preparation antibacterial antifungal antitubercular antimalarial activity.

Target mols. based on imidazothiazole-chalcone derivatives I (R1 = H, OH, NO2, MeO; R2 = H, OH, NO2, MeO, Br, Cl, Me) and imidazothiazole-pyrimidine derivatives II were synthesized. Chalcone series of compounds I was synthesized by reaction between 2-(4-methoxybenzyl)-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde and various substituted acetophenones 4-R2-3-R1C6H3C(O)Me and these chalcones I were converted into pyrimidine series II. These derivatives of chalcones and pyrimidine were examined in vitro for antimicrobial and antifungal activities against clin. isolated strains and their characterization was confirmed by FTIR, 1H-NMR, 13C and LCMS.

Chemistry & Biology Interface published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bayrak, Cetin published the artcileMonodisperse NiPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride as a catalyst for the highly efficient chemoselective reduction of α,β-unsaturated ketone compounds, Category: isoquinoline, the main research area is diphenyl propanone preparation chemoselective; chalcone transfer hydrogenation nickel palladium alloy nanoparticle catalyst preparation.

The study of extraordinary chemoselective reduction with selectivity (>99%) by the catalytic transfer hydrogenation of various α,β-unsaturated ketones RC(O)CH=CHR1 (R = 4-methylphenyl, 4-methoxyphenyl, 2,4-dimethoxyphenyl; R1 = 2,3-dimethoxyphenyl, 4-methylphenyl, 4-methoxyphenyl, 2,4-dimethoxyphenyl, 3,4,5-trimethoxyphenyl) with a catalyst of NiPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride (NiPd/mpg-C3N4) under mild conditions in a water/methanol medium was reported. NiPd alloy NPs were synthesized by the reduction of metal salts in oleylamine (OAm) solution with the help of borane-tert-butylamine and then decorated on mpg-C3N4 via a liquid phase self-assembly method. The NiPd/mpg-C3N4 nanocatalyst is a highly active catalyst for the chemoselective reduction of α,β-unsaturated ketones and all organic compounds were converted with high yield and 99% selectivity. In addition, the catalyst can be reused five times without an important loss in reaction yield.

New Journal of Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem