Month: November 2022

Yang, Jie published the artcileSynthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer’s disease agents, Safety of 4-Methoxyphenylacetic acid, the main research area is synthesis arylcoumarin Alzheimer disease agent; 3-Arylcoumarin; Alzheimer’s disease; antioxidant activity; cholinesterase inhibitors; monoamine oxidase inhibitors.

Alzheimer’s disease, a neurodegenerative illness, has the extremely complex pathogenesis. Accumulating evidence indicates there is a close relationship between several enzymes and Alzheimer’s disease. Various substituted 3-arylcoumarin derivatives were synthesized, and their in vitro activity, including cholinesterase inhibitory activity, monoamine oxidase inhibitory activity, and antioxidant activity were investigated. Most of the compounds exhibited high activity; therefore 3-arylcoumarin compounds have the potential as drug candidates for the treatment of Alzheimer’s disease.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Alzheimer disease. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Safety of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Javed, Muhammad Aamir published the artcileStructural Modification, In Vitro, In Vivo, Ex Vivo, and In Silico Exploration of Pyrimidine and Pyrrolidine Cores for Targeting Enzymes Associated with Neuroinflammation and Cholinergic Deficit in Alzheimer’s Disease, Application In Synthesis of 598-50-5, the main research area is pyrimidine pyrrolidine tacrine derivative enzyme targets antiinflammatory Alzheimer disease; MTDL; in vivo anti-inflammatory; pyrimidine; pyrrolidine; tacrine derivative.

To obtain a multi-potent framework that can target simultaneously COX-2, 5-LOX, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation, a series of derivatives containing pyrimidine and pyrrolidine cores were rationally synthesized and evaluated. Pyrazoline-pyrimidine hybrid (23g), (3-acetylcoumarin derivative of pyrrolidin-1-yl)benzenesulfonamide (27), and tacrine derivatives of (pyrrolidin-1-yl)benzenesulfonamide (31, 38) displayed excellent in vitro COX-2 inhibition having IC50 value in the nanomolar range. Tacrine-pyrrolidine hybrids 36 and 38, and tacrine-pyrimidine hybrid (46) emerged as the most potent eeAChE inhibitors with IC50 values of 23, 16, and 2 nM, resp. However, compounds 27, 31, and 38 possessed excellent simultaneous and balanced inhibitory activity against all of the four tested targets and thus emerged as optimal multi-potent hybrid compounds among all of the synthesized series of the compounds In the ex vivo, transgenic animal models treated with compounds 36 and 46 displayed a significant decline in both AChE and BChE potentials in the hippocampus and cortical tissues. In anti-inflammatory activities, animals treated with compounds 36 and 46 displayed a significant % inhibition of edema induced by carrageenan and arachidonic acid. Biochem. anal. and histopathol. examination of mice liver indicate that tacrine derivatives are devoid of hepatotoxicity and neurotoxicity against SH-SY5Y neuroblastoma cell lines. In vivo acute toxicity study showed the safety of synthesized compounds up to 1000 mg/kg dose. The inhibitory manner of interaction of these potent drugs on all of the studied in vitro targets was confirmed by mol. docking investigations.

ACS Chemical Neuroscience published new progress about Alzheimer disease. 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, Application In Synthesis of 598-50-5.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Mingjun published the artcileMarine Natural Product for Pesticide Candidate: Pulmonarin Alkaloids as Novel Antiviral and Anti-Phytopathogenic-Fungus Agents, HPLC of Formula: 104-01-8, the main research area is antiviral biofungicide pulmonarin analog preparation antiviral phytopathogenic fungus; antiviral activity; fungicidal activity; marine natural product; mode of action; pulmonarins A and B; structure optimization.

Plant diseases are seriously endangering agricultural production The emergence of drug resistance has brought great challenges to the prevention and control of plant diseases. There is an urgent need for the emergence of new drug candidates. In this work, we achieved the efficient synthesis of pulmonarins A and B in 64% and 59% overall yield, resp. Pulmonarins A and B were found to have good antiviral activities against tobacco mosaic virus (TMV) for the first time. A series of pulmonarin derivatives were designed, synthesized, and evaluated for their antiviral and fungicidal activities systematically. Most compounds displayed higher anti-TMV activities than com. ribavirin. Compounds Pulmonarin B, -Benzyl-2-((3,5-dibromo-4-methoxybenzoyl)oxy)-N,N-dimethylethan-1-aminium Bromide (I), and 2-((4-(Allyloxy)-3,5-dibromobenzoyl)oxy)-N,N,N-trimethylethan-1-aminium Iodide with better inactivation effects than ningnanmycin emerged as new antiviral candidates. We selected I for further antiviral mechanism research, which revealed that it could inhibit virus assembly by interacting with TMV coat protein (CP). The mol. docking results further confirmed that these compounds could interact with CP through hydrogen bonding. These compounds also displayed broad spectrum fungicidal activities. Especially compound 2-(2-(3,5-Dibromo-4-methoxyphenyl)acetoxy)-N,N,N-trimethylethan-1-aminium Iodide with prominent antifungal activity emerged as a new fungicidal candidate for further research. The current work provides a reference for understanding the application of pulmonarin alkaloids in plant protection.

Journal of Agricultural and Food Chemistry published new progress about Alternaria solani. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, HPLC of Formula: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Yonglong published the artcileTunable Photocatalytic Two-Electron Shuttle between Paired Redox Sites on Halide Perovskite Nanocrystals, Formula: C8H10O2, the main research area is tunable photocatalytic two electron shuttle halide perovskite nanocrystal photocatalyst.

Perovskite semiconductors as advanced solar energy-converting materials are promising catalysts for photoredox organic synthesis. Despite the high concentration of charge carriers generated on the perovskite surface, efficient utilization of these nonequilibrium and shambolic energetic carriers to trigger a chem. reaction remains a hot and challenging subject. Here, we report a photon-mediated electron shuttle between paired redox sites on perovskite nanocrystals for the reformation of highly stable carbon-halogen bonds, where both surface electrons and holes are utilized simultaneously. The photo-redox cascade can be effortlessly tailored by precise control of the surface-reducing/-oxidizing reaction rates, which unlocks the transformation for a wide range of (het)arenes. This work demonstrates colloidal perovskite photocatalysts for the direct installation of more than 10 different synthetically important functional groups onto arenes and heteroarenes.

ACS Catalysis published new progress about Adsorption energy. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Schwarz, J. Luca published the artcile1,2-Amino Alcohols via Cr/Photoredox Dual-Catalyzed Addition of α-Amino Carbanion Equivalents to Carbonyls, SDS of cas: 1205-17-0, the main research area is amino alc preparation; aminomethylsilane carbonyl compound photoredox addition chromium catalyst photocatalyst.

Herein, we report the synthesis of protected 1,2-amino alcs. starting from carbonyl compounds and α-silyl amines. The reaction is enabled by a Cr/photoredox dual catalytic system that allows the in situ generation of α-amino carbanion equivalent which act as nucleophiles. The unique nature of this reaction was demonstrated through the aminoalkylation of ketones and an acyl silane, classes of electrophiles that were previously unreactive toward addition of alkyl-Cr reagents. Overall, this reaction broadens the scope of Cr-mediated carbonyl alkylations and discloses an underexplored retrosynthetic strategy for the synthesis of 1,2-amino alcs.

Journal of the American Chemical Society published new progress about Addition reaction. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, SDS of cas: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sun, Wei published the artcileChemodivergent transformations of amides using gem-diborylalkanes as pro-nucleophiles, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is amide diborylalkane chemoselective addition elimination reaction.

A chemodivergent transformation of primary, secondary and tertiary amides by using 1,1-diborylalkanes as pro-nucleophiles was disclosed. In general, selective B-O elimination occurred for primary, secondary amides and tertiary lactams to generated enamine intermediate, while tertiary amides undergo B-N elimination to generated enolate intermediate. Various in-situ electrophilic trapping of those intermediates allowed the chemoselective synthesis of α-functionalized ketones, β-aminoketones, enamides, β-ketoamides, γ-aminoketones and cyclic amines from primary, secondary, tertiary amides and lactams. The key for these transformations was the enolization effect after the addition of α-boryl carbanion to amides.

Nature Communications published new progress about Addition reaction. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chan, Yuk-Cheung published the artcileHalogen-Bond-Catalyzed Addition of Carbon-Based Nucleophiles to N-Acylimminium Ions, Computed Properties of 151-10-0, the main research area is nucleophile hemiaminal ether addition iodoimidazolium; isoindoline preparation; iodoimidazolium addition catalyst.

N-acylimminium ions are an important class of synthetic intermediates to produce diverse products upon treatment with different nucleophiles. Most of the reported catalytic protocol involved moisture-sensitive Lewis acids or transition metal. Herein, an organocatalytic version by using halogen-bond catalyst as mild Lewis acid through anion-abstraction strategy, is reported. A preliminary result of enantioselective version by employing a chiral BINOL-phosphate anion has also been demonstrated.

Organic Letters published new progress about Addition reaction. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Subagyono, Rr dirgarini j. n. published the artcilePyrolysis of fast growing wood Macaranga gigantea: Product characterisation and kinetic study, SDS of cas: 86-51-1, the main research area is growing wood macaranga gigantea pyrolysis activation energy.

Fast-growing wood Macaranga gigantea has been pyrolyzed and its pyrolysis products have been characterized and their formation kinetics studied. Pyrolysis of M. gigantea wood was carried out by varying the temperature and time of pyrolysis to determine the effect of these two parameters on product yields and product characteristics. In general, an increase in pyrolysis temperature and time increased the yield of liquid and gas products, the concentration of cellulose, hemicellulose and lignin-derived compounds, but decreased the biochar yield. The organic phase liquid pyrolysis products mainly contained phenolic compounds and their derivatives, eugenols, furans, aldehydes and ketones. Fourier-transform IR spectroscopy and pyrolysis-gas chromatog.-mass spectrometry analyses of biochar showed that thermal decomposition of M. gigantea required temperatures higher than 300°C to optimize thermal decomposition and carbonization of lignin, cellulose and hemicellulose. The concentration of phenols and benzenediols in biochar decreased with an increase in pyrolysis temperature M. gigantea pyrolysis kinetics studies showed that wood pyrolysis occurred through four main stages with activation energy (Eα) values, based on calculations by the Friedman and Kissinger-Akahira-Sunose methods, of 28.1-99.0 kJ/mol and 35.6-104.9 kJ/mol, resp. The spectra produced by thermogravimetric analyzer coupled with a Fourier-transform IR spectroscopy showed that H2O and CO2 were produced during pyrolysis and the volatile compounds produced were predominantly phenolic compounds, in accord with characterization results of the liquid products by gas chromatog.-mass spectrometry and NMR spectroscopy.

Fuel published new progress about Activation energy. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, SDS of cas: 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yuan, Jun published the artcileA phosphaphenanthrene-based derivative as multifunctional flame retardant for epoxy resins, SDS of cas: 1455-77-2, the main research area is phosphaphenanthrene multifunctional flame retardant epoxy resin.

In this work, the transparent, mech. strengthened, flame retardant and smoke suppression epoxy resin (EP) composites was prepared by the addition of an indole/phosphaphenanthrene-based compound (IDT). The results presented that limiting oxygen index (LOI) of EP composite containing 5 weight% IDT raised to 32% and it passed a UL-94 V-0 rating. In the meantime, compared with EP, total smoke production (TSP) and the peak of heat release (PHRR) of EP/IDT5 were decreased by 51.9% and 32.1%, resp. The flame-retardant mechanism of EP/IDT was also explored by pyrolysis/gas chromatog.-mass spectrometry (Py-GC/MS), scanning electron microscope (SEM) and XPS. Besides, the bending and tensile strengths were improved thanks to the presence of π-π conjugation and hydrogen bonds between IDT and EP. This work provided a promising way to meet the increasing multifunctional requirements of EP composites.

Reactive & Functional Polymers published new progress about Activation energy. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, SDS of cas: 1455-77-2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yuan, Jun published the artcileA phosphaphenanthrene-based derivative as multifunctional flame retardant for epoxy resins, Product Details of C2H5N5, the main research area is phosphaphenanthrene multifunctional flame retardant epoxy resin.

In this work, the transparent, mech. strengthened, flame retardant and smoke suppression epoxy resin (EP) composites was prepared by the addition of an indole/phosphaphenanthrene-based compound (IDT). The results presented that limiting oxygen index (LOI) of EP composite containing 5 weight% IDT raised to 32% and it passed a UL-94 V-0 rating. In the meantime, compared with EP, total smoke production (TSP) and the peak of heat release (PHRR) of EP/IDT5 were decreased by 51.9% and 32.1%, resp. The flame-retardant mechanism of EP/IDT was also explored by pyrolysis/gas chromatog.-mass spectrometry (Py-GC/MS), scanning electron microscope (SEM) and XPS. Besides, the bending and tensile strengths were improved thanks to the presence of π-π conjugation and hydrogen bonds between IDT and EP. This work provided a promising way to meet the increasing multifunctional requirements of EP composites.

Reactive & Functional Polymers published new progress about Activation energy. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Product Details of C2H5N5.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem