Sun, Wei published the artcileChemodivergent transformations of amides using gem-diborylalkanes as pro-nucleophiles, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is amide diborylalkane chemoselective addition elimination reaction.
A chemodivergent transformation of primary, secondary and tertiary amides by using 1,1-diborylalkanes as pro-nucleophiles was disclosed. In general, selective B-O elimination occurred for primary, secondary amides and tertiary lactams to generated enamine intermediate, while tertiary amides undergo B-N elimination to generated enolate intermediate. Various in-situ electrophilic trapping of those intermediates allowed the chemoselective synthesis of α-functionalized ketones, β-aminoketones, enamides, β-ketoamides, γ-aminoketones and cyclic amines from primary, secondary, tertiary amides and lactams. The key for these transformations was the enolization effect after the addition of α-boryl carbanion to amides.
Nature Communications published new progress about Addition reaction. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem