Month: December 2022

Zhou, Lei published the artcileInvestigations of diatrizoate degradation by photo-activated persulfate, Related Products of isoquinoline, the main research area is diatrizoate UV photodegradation persulfate hydroxyl.

The widespread occurrence of iodinated X-ray contrast media (ICMs) in aquatic systems poses potential risks to ecol. system and human health. The present study investigated the degradation kinetics and mechanisms of a typical ICMs, diatrizoate (DTZ), by using simulated sunlight (from a solar simulator Suntest CPS+) activated persulfate (PS) oxidation process. The influence of key kinetic factors, such as PS concentrations, pH, dissolved organic matter (DOM), bicarbonate and chloride ions was evaluated. The reaction pathways and mechanisms were proposed based on photoproducts identification using HPLC-MS. UV/PS was found to be more efficient than UV/H2O2. Sulfate radicals (SO·-4) was the dominant reactive species in the oxidation process, and the second-order rate constant of sulfate radical with DTZ was calculated as 1.90 × 109 M-1s-1 based on laser flash photolysis (LFP) experiments The results indicated that increasing initial PS concentration favored the decomposition of DTZ; whereas, degradation of DTZ was not affected by pH change ranging from 4.5 to 8.5. DOM inhibited DTZ removal rate, while, bicarbonate enhanced it, and chloride ions induced a neg. effect above 500 mM. Major oxidation pathways including deiodination-hydroxylation, decarboxylation- hydroxylation and side chain cleavage were proposed, and detailed underlying mechanisms were also discussed. We suggest a direct photodegradation of primary intermediates generated by SO·-4 attack. These findings demonstrate that halogenated pollutants can readily react with SO·-4 to form light-absorbing intermediates (ranging from 350 to 500 nm). Thus, this activation method could be a promising approach in the removal of ICMs.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Deiodination. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Andreucci, Michele published the artcileReversal of radiocontrast medium toxicity in human renal proximal tubular cells by white grape juice extract, Formula: C11H9I3N2O4, the main research area is radiocontrast medium nephrotoxicity radiotoxicity Vitis juice extract radioprotectant; Cell injury; Kinase; Renal cell; Signaling; Vitis spp..

Radiocontrast media (RCM)-induced nephrotoxicity (CIN) is a major clin. problem accounting for 12% of all hospital-acquired cases of acute kidney injury. The pathophysiol. of CIN is not well understood, but direct toxic effects on renal cells have been postulated as contributing to CIN. We have investigated the effect of a white grape (Vitis vinifera) juice extract (WGJe) on human renal proximal tubular (HK-2) cells treated with the radiocontrast medium (RCM) sodium diatrizoate. WGJe caused an increase in phosphorylation of the prosurvival kinases Akt and ERK1/2 in HK-2 cells. Treatment of HK-2 cells with 75 mg I/mL sodium diatrizoate for 2.5 h and then further incubation (for 27.5 h) after removal of the RCM caused a drastic decrease in cell viability. However, pre-treatment with WGJe, prior to incubation with diatrizoate, dramatically improved cell viability. Anal. of key signaling mols. by Western blotting showed that diatrizoate caused a drastic decrease in phosphorylation of Akt (Ser473), FOXO1 (Thr24) and FOXO3a (Thr32) during the initial 2.5 h incubation period, and WGJe pre-treatment caused a reversal of these effects. Further anal. by Western blotting of samples from HK-2 cells cultured for longer periods of time (for up to 27.5 h after an initial 2.5 h exposure to diatrizoate with or without WGJe pre-treatment) showed that WGJe pre-treatment caused a neg. effect on phosphorylation of p38, NF-κB (Ser276) and pERK1/2 while having a pos. effect on the phosphorylation of Akt, FOXO1/FOXO3a and maintained levels of Pim-1 kinase. WGJe may alleviate RCM toxicity through modulation of signaling mols. that are known to be involved in cell death and cell survival and its possible beneficial effects should be further investigated.

Chemico-Biological Interactions published new progress about Cytotoxicity. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Formula: C11H9I3N2O4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ray, Parijat published the artcileDevelopment of bio-acrylic polymers from Cyrene: transforming a green solvent to a green polymer, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is cyrene bioacrylic polymer polymerization.

In this work, Cyrene, a bio-based green solvent, has been transformed into its methacrylic derivative (m-Cyrene) for the first time. Polymerization of the newly-synthesized monomer was studied using different polymerization techniques such as bulk, solution and emulsion polymerization Compared to solution polymerization, emulsion polymerization was found to produce higher yields and mol. weights Cyrene, along with other green solvents, was used as a polymerization solvent and was found to be the most effective (as a solvent) with the highest yield and mol. weight The new Cyrene monomer was found to undergo rapid polymerization compared to isobornyl methacrylate (IBMA), another bio-derived monomer with a close structural similarity, and the highest polymerization rate was obtained in Cyrene as the polymerization solvent media. A reactivity ratio calculation also showed m-Cyrene to be more reactive than IBMA. The homopolymer derived from emulsion polymerization showed high glass transition temperature (192°C) and thermal stability (up to ca. 266°C). Cytotoxicity testing confirmed the non-toxic nature of the bio-derived monomer, making it a green bio-derived methacrylic monomer for synthesizing polymers, where high thermal stability and mech. properties are required.

Polymer Chemistry published new progress about Cytotoxicity. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Eva-Maria, Prantl published the artcileComparison of in vitro test systems using bacterial and mammalian cells for genotoxicity assessment within the “”health-related indication value (HRIV) concept, Synthetic Route of 117-96-4, the main research area is bacterial mammalian cell genotoxicity health related indication value concept; Drinking water; Genotoxicity; Germany; HRIV concept; Risk assessment; Test battery; Tox-Box.

In numerous cases, the German health-related indication value (HRIV) concept has proved its practicability for the assessment of drinking water relevant trace substances (Umweltbundesamt 2003). The HRIV is based on the toxicol. profile of a substance. An open point of the HRIV concept has been the assignment of standardized test procedures to be used for the assessment. The level of the HRIV is at its lowest as soon as the genotoxicity of the substance is detected. As a single test on its own, it is not sufficient enough to assess the human toxicol. relevance of a genotoxic effect or exclude it in the case of a neg. result; a reasonable test battery was required, tech. oriented towards the already harmonized international, hierarchical evaluation for toxicol. assessment of chems. Therefore, an important aim of this project was to define a strategy for the genotoxicol. assessment of anthropogenic trace substances. The basic test battery for genotoxicity of micropollutants in drinking water needs to fulfill several requirements. Although quick test results are needed for the determination of HRIV, a high degree of transferability to human genotoxicity should be ensured. Therefore, an in vitro genotoxicity test battery consisting of the Ames fluctuation test with two tester strains (ISO 11350), the umu test and the micronucleus test, or from the Ames test with five tester strains (OECD 471) and the micronucleus test is proposed. On the basis of selected test substances, it could be shown that the test battery leads to pos., indifferent, and neg. results. Given indifferent results, the health authority and the water supplier must assume that it is a genotoxic substance. Genetically modified tester strains are being sensitive to different chem. classes by expression of selected mammalian key enzymes for example nitroreductase, acetyltransferase, and glutathione-S-transferase. These strains may provide valuable addnl. information and may give a first indication of the mechanism of action. To check this hypothesis, various addnl. strains expressing specific human-relevant enzymes were investigated. It could be shown that the addnl. use of genetically modified tester strains can enhance the detectable substance spectrum with the bacterial genotoxicol. standard procedures or increase the sensitivity. The addnl. use provides orienting information at this level as a lot of data can be obtained quite quickly and with little effort. These indications of the mechanism of action should be however verified with a test system that uses mammalian cells, better human cells, to check their actual relevance. The selection of appropriate addnl. tester strains has to be defined from case to case depending on the mol. structure and also still requires some major expertise.

Environmental Science and Pollution Research published new progress about Cytotoxicity. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Synthetic Route of 117-96-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Spitta, Luis F. published the artcileAn in-vitro approach for water quality determination: activation of NF-κB as marker for cancer-related stress responses induced by anthropogenic pollutants of drinking water, Recommanded Product: Diatrizoic Acid, the main research area is NF kappaB cancer stress response anthropogenic pollutant drinking water; Cytotoxicity; Environmental toxicology; Fluorescence based reporter assay; Genotoxicity; NF-kappaB; TOX-Box.

Epidemiol. studies show that there is a link between urban water pollution and increase in human morbidity and mortality. With the increase in number of new substances arising from the chem., pharmaceutical, and agricultural industries, there is an urgent need to develop biol. test systems for fast evaluation of potential risks to humans and the environmental ecosystems. Here, a combined cellular reporter assay based on the cellular survival and the stress-induced activation of the survival-promoting factor nuclear factor κB (NF-κB) and its use for the detection of cytotoxicity and cancer-related stress responses is presented. A total of 14 chems. that may be found in trace-amounts in ground water levels are applied and tested with the presented assay. The project is embedded within the joint research project TOX-BOX which aims to develop a harmonized testing strategy for risk management of anthropogenic trace substances in potable water. The assay identified carbendazim as a NF-κB-activating agent in mammalian cells.

Environmental Science and Pollution Research published new progress about Cytotoxicity. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Recommanded Product: Diatrizoic Acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Fucke, Katharina published the artcileOvercoming the solvation shell during the crystallisation of diatrizoic acid from dimethyl sulfoxide, Formula: C11H9I3N2O4, the main research area is diatrizoic acid crystallization dimethyl sulfoxide desolvation.

We present three crystal structures of diatrizoic acid (DTA) DMSO solvates illustrating progressive desolvation of the DTA mol. and concomitant increasing degree of DTA self-association Using these structures, plausible pathways for overcoming the solvation shell of DTA during its crystallization from solution are discussed.

Chemical Communications (Cambridge, United Kingdom) published new progress about Conformation. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Formula: C11H9I3N2O4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Merzlikine, Alexei published the artcileDevelopment of machine learning models of β-cyclodextrin and sulfobutylether-β-cyclodextrin complexation free energies, Formula: C11H9I3N2O4, the main research area is machine learning modeling beta cyclodextrin sulfobutylether complexation energy.

A new set of 142 exptl. determined complexation constants between sulfobutylether-β-cyclodextrin and diverse organic guest mols., and 78 observations reported in literature, were used for the development of the QSPR models by the two machine learning regression methods – Cubist and Random Forest. Similar models were built for β-cyclodextrin using the 233-compound dataset available in the literature. These results demonstrate that the machine learning regression methods can successfully describe the complex formation between organic mols. and β-cyclodextrin or sulfobutylether-β-cyclodextrin. In particular, the root mean square errors for the test sets predictions by the best models are low, 1.9 and 2.7 kJ/mol, resp. The developed QSPR models can be used to predict the solubilizing effect of cyclodextrins and to help prioritizing exptl. work in drug discovery.

International Journal of Pharmaceutics published new progress about Complexation. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Formula: C11H9I3N2O4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Rosenberg, Martin published the artcileExtended Triangulenium Ions: Syntheses and Characterization of Benzo-Bridged Dioxa- and Diazatriangulenium Dyes, Name: 1,3-Dimethoxybenzene, the main research area is benzo bridged dioxatriangulenium diazatriangulenium dye synthesis fluorescence electrochem property.

The very limited class of fluorophores with long fluorescence lifetime (> 10 ns) and fluorescence beyond 550 nm, has been expanded with two benzo-fused triangulenium derivatives and two cationic [5]-helicene salts. The syntheses of the benzo-bridged dioxa- and diazatriangulenium derivatives (BDOTA+ and BDATA+, resp.) required two different synthetic approaches, which reflect the structural and physiochem. impact on the reactivity of [5]-helicenium precursors. Spectroscopic investigations show that introduction of the benzo-bridge into the triangulenium chromophore significantly red shifts the absorption and emission while maintaining fluorescence lifetimes above 10 ns. The combination of high quantum yield, long fluorescence lifetime, and emission above 600 nm is possible only if the structural aspects of the triangulenium framework are perfectly harmonized to secure a low rate of non-radiative deactivation. The new benzo-bridge may be a general motif to obtain red shifted derivatives of other dye classes.

Journal of Organic Chemistry published new progress about Chromophores. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yang, Minfeng published the artcileDesign and synthesis of Phenylaminothiophene donor-based chromophore with enhanced electro-optic activity, SDS of cas: 5961-59-1, the main research area is phenylaminothiophene chromophore preparation electro optical property.

Three novel chromophores B-D have been synthesized based on thiophene derivatived donors, including 5-(methyl(phenyl)amino)thiophene 5-(bis(4-methoxyphenyl)amino)thiophene 5-((4-methoxyphenyl)(methyl)amino)thiophene groups resp., with the same isophorone-derived bridge and tricyanovinyldihydrofuran (TCF) acceptors. A new strategy was proposed to improve the electron donating ability of the chromophore, thienyl groups were explored as a replacement for the Ph unit in the donor part of the chromophore. D. functional theory calculations suggested that the first hyperpolarizability of (arylamino) thiophene donor-containing chromophore B-D is about 20% higher than that of 4-(dialkylamino) Ph counterpart chromophore A. At least 50% enhancement in bulk nonlinearity (r33) is realized as the donor subunits were changed from alkylaniline to (arylamino) thiophene donors. Polymeric thin films doped with 25 wt% chromophore B-D have been poled to afford large r33 values of 131, 143 and 138 p.m./V at 1.31μm, resp., which is much higher than the EO activity of chromophore A (88 pm/V).

Dyes and Pigments published new progress about Chromophores. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, SDS of cas: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lopez-Prieto, Israel J. published the artcileFormation and control of disinfection by-products from iodinated contrast media attenuation through sequential treatment processes of ozone-low pressure ultraviolet light followed by chlorination, Name: Diatrizoic Acid, the main research area is ozone disinfection UV light wastewater treatment chlorination; Chlorine disinfection; Iodinated-disinfection by-products; Iopamidol attenuation; Pre-ozonation; UV photolysis.

Different groups of disinfection byproducts (DBPs) were studied through the degradation of iopamidol by the sequential oxidation process of ozone-low pressure UV light (O3-LPUV) followed by chlorination. This paper investigates the attenuation of iopamidol under this sequential treatment and the effect of chlorine contact time (30 min vs. 3 days) to control the formation potential of DBPs: trihalomethanes (THMs), haloacetonitriles (HANs) and haloacetamides (HAMs). Thirty target DBPs among the 9 iodinated-DBPs (I-DBPs), were monitored throughout the sequential treatment. Results showed that O3-LPUV removed up to 99% of iopamidol, while ozone and LPUV alone removed only 90% and 76% resp. After chlorine addition, O3-LPUV yielded 56% lower I-DBPs than LPUV. Increasing chlorine contact time resulted in higher concentrations of all DBP groups (THMs, HANs, and HAMs), with the exception of I-DBPs. One new iodinated-haloacetamide, namely chloroiodoacetamide (CIACM) and one iodoacetonitrile (IACN) were detected. These results suggest the iodine incorporated in iopamidol may be a precursor for iodinated-nitrogenous-DBPs, which are currently not well studied.

Chemosphere published new progress about Chlorination. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Name: Diatrizoic Acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem