Category: 104-01-8

Soni, Vineet Kumar published the artcileReactivity Tuning for Radical-Radical Cross-Coupling via Selective Photocatalytic Energy Transfer: Access to Amine Building Blocks, Computed Properties of 104-01-8, the main research area is imine green preparation iridium photocatalyst; oxime ester decarboxylative radical cross coupling.

Reductive N-O bond cleavage has been widely explored for providing either N or O radical species for various coupling processes. Despite significant advances, this photoredox pathway is less appealing due to poor atom-economy, owing to the loss of one fragment during the transformation. In this regard, homolytic N-O bond cleavage by an energy transfer pathway to provide two key radicals would be highly desirable for overcoming the limitations with the use of one fragment. An exclusive energy transfer approach for the development of radical-radical C-N cross-coupling process by reactivity-tuning of the catalytic system is reported. The homolytic N-O bond cleavage of oxime esters in the presence of an Ir complex produces acyloxy and iminyl radicals, which underwent decarboxylative cross-coupling to yield valuable imines I (R = Bn, t-Bu, heptyl, etc.; R1 = Ph, 4-F3CC6H4, 4-ClC6H4, etc.; R2 = Me, 4-F3CC6H4, 2-pyridyl, etc.). Extensive photophys. and electrochem. measurements, as well as DFT studies, were carried out to probe the mechanism and revealed the operation of a Dexter-type energy transfer pathway. The synthetic utility of this method was explored by studying highly functionalized oxime esters, including derivatives of biol. active natural products and drug mols. Furthermore, in situ transformations of the imine products into pharmaceutically important amines were also demonstrated, showcasing the utility of the imine products as valuable amine building blocks.

ACS Catalysis published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

van der Heijden, Gydo published the artcileEfficient Diastereoselective Three-Component Synthesis of Pipecolic Amides, Quality Control of 104-01-8, the main research area is pipecolic acid amide diastereoselective preparation; piperideine preparation Ugi reaction; argatroban stereoselective preparation; stereoselective Ugi reaction piperideine isocyanide carboxylic acid.

An efficient Ugi-type three-component reaction (U-3CR) of isocyanides, carboxylic acids and 4-substituted Δ1-piperideines for the synthesis of pipecolic amides such as I is reported. Hydrogenation of 4-substituted pyridines (prepared by alkylation of 4-picoline with alkyl bromides) yielded the 4-substituted piperidines or their hydrochloride salts; oxidation of the piperidines with NCS yielded the Δ1-piperideines which were used without purification The method was used to prepare the anticoagulant argatroban.

European Journal of Organic Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Quality Control of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ye, Zenghui published the artcileEnantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is functionalized hindered triazolopyridinone derivative enantioselective preparation; pyridyl hydrazide preparation electrochem oxidative rearrangement; carboxylic acid hydrazine pyridyl hydrazide preparation.

An electrochem. rearrangement for efficient synthesis of inaccessible triazolopyridinones I [R1 = H, Me, Ph, etc.; R2 = H, Me, F, etc., R3 = Et, OTBS, 2-thienyl, etc.; R1R2 = cyclpropyl, adamantan-1-yl, tetrahydrofuran-2-yl, etc.; R4 = H, 8-Cl, 6-COOEt, etc.] with diverse alkyl carboxylic acids as starting materials was reported. This enabled efficient preparation of more than 60 functionalized triazolopyridinones I under mild conditions in a sustainable manner. This method was evaluated for late stage modification of bioactive natural products, amino acids and pharmaceuticals, and it was further applied to decagram scale preparation of enantiopure triazolopyridinones. The control experiments supported a mechanism involving an oxidative cyclization and 1,2-carbon migration. This facile and scalable rearrangement demonstrated power of electrochem. synthesis to access otherwise-inaccessible triazolopyridinones and may find wide application in organic, material and medicinal chem.

Nature Communications published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Matsubara, Ryosuke published the artcileModular Synthesis of Carbon-Substituted Furoxans via Radical Addition Pathway. Useful Tool for Transformation of Aliphatic Carboxylic Acids Based on “”Build-and-Scrap”” Strategy, Application of 4-Methoxyphenylacetic acid, the main research area is furoxan regioselective preparation; silver catalyst oxidative radical substitution arylsulfonyl furoxan alkylcarboxylic acid; build and scrap strategy radical functionalization furoxan.

Bis(arylsulfonyl)furoxans such as I (R = 4-MeC6H4, 4-ClC6H4, 4-FC6H4, 3-F3CC6H4, Ph) underwent regioselective substitution reactions with alkyl radicals generated from carboxylic acids such as Ph(CH2)3CO2H with K2S2O8 in the presence of AgNO3 in aqueous MeCN, allowing regioselective functionalization of furoxans. Further isomerization and substitution reactions allowed the regioselective preparation of a variety of furoxans such as II (R1 = PhSO2, 4-MeC6H4SO2, Me(CH2)5CC, F3C, EtO, PhO, EtS). II (R = PhSO2, EtO, F3C) were converted to a variety of compounds including oximes, amines and diamines, nitro compounds, nitriles, an oxadiazole, and isoxazoles and dihydroisoxazoles; the furoxan moiety can thus be used to form a variety of functional groups by a “”build-and-scrap”” strategy. The mechanisms of the addition and elimination steps of the regioselective substitution reactions bis(arylsulfonyl)furoxans was studied to account for the observed regioselectivities.

Organic Letters published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yuan, Shiru published the artcile[2.2]Paracyclophane-Based Isothiourea-Catalyzed Highly Enantioselective α-Fluorination of Carboxylic Acids, SDS of cas: 104-01-8, the main research area is fluoroester preparation enantioselective; carboxylic acid fluorination paracyclophane isothiourea catalyst.

Planar chiral [2.2]paracyclophane-based isothiourea catalysts have been prepared over a few simple steps in high yields. In the presence of these catalysts, highly efficient catalytic enantioselective fluorination of carboxylic acids has been accomplished, providing a broad range of optically active α-fluoroesters in high yield and excellent enantioselectivity.

Organic Letters published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Han, Qiu-Yan published the artcileOrganic Photoredox-Catalyzed Decarboxylative Trifluoromethylselenolation of Aliphatic Carboxylic Acids with [Me4N][SeCF3], HPLC of Formula: 104-01-8, the main research area is trifluoromethyl selenoether preparation green chem; aliphatic carboxylic acid oxidative decarboxylative trifluoromethylselenolation photoredox catalyst.

Oxidative decarboxylation/trifluoromethylselenolation of primary, secondary, and tertiary aliphatic carboxylic acids with the nucleophilic [Me4N][SeCF3] salt and an organic photocatalyst is described. The reaction proceeds smoothly at room temperature under transition-metal-free conditions and affords the corresponding trifluoromethylselenolated products in good yields. Advantages of the method include good functional group tolerance, without preactivation of the acids, and late-stage functionalization of the complex drug mols. This protocol represents the first decarboxylative trifluoromethylselenolation of carboxylic acids to trifluoromethyl selenoethers.

Organic Letters published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, HPLC of Formula: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Guo, Yu published the artcilePhotoinduced Decarboxylative Phosphorothiolation of N-Hydroxyphthalimide Esters, Computed Properties of 104-01-8, the main research area is photoinduced decarboxylative phosphorothiolation hydroxyphthalimide ester green mechanism; phosphorothioate preparation green chem steric effect photoinduced.

A visible-light-induced protocol for the synthesis of phosphorothioates is developed by employing the Ir-catalyzed decarboxylative phosphorothiolation of N-hydroxyphthalimide esters. This novel synthesis method utilizes carboxylic acids as raw material, which is stable, cheap, and com. available. Scope studies show that this reaction has good compatibility of functional groups. Notably, both the synthesis of steric hindrance phosphorothioates and the later modification of some bioactive compounds are successfully achieved.

Organic Letters published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

M. L., Chenna Reddy published the artcileFacile synthesis of N-1,2,4-oxadiazole substituted sulfoximines from N-cyano sulfoximines, Application of 4-Methoxyphenylacetic acid, the main research area is synthesis oxadiazole sulfoximine; cyano sulfoximine carboxylic acid cyclization.

A divergent approach has been successfully developed for synthesis of N-1,2,4-oxadiazole substituted sulfoximines starting from N-cyano sulfoximines. This method has a wide degree of substrate scope that includes aryl, heteroaryl, alkyl, fluoroalkyl and saturated heterocyclic compounds Excellent functional group tolerability was also observed Extension of this methodol. to nucleosides, amino acids and dipeptides was found to be successful. A gram scale reaction was also established. The major part of this method is metal free and the utility of environmentally friendly solvents such as 2-Me THF and ionic liquids is an added advantage.

Organic & Biomolecular Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Varaprasad, Bodala published the artcileCopper-catalyzed efficient access to 2,4,6-triphenyl pyridines via oxidative decarboxylative coupling of aryl acetic acids with oxime acetates, Safety of 4-Methoxyphenylacetic acid, the main research area is triphenyl pyridine preparation; aryl acetic acid oxime acetate oxidative decarboxylative coupling copper.

An efficient and concise approach for the synthesis of 2,4,6-tri-Ph pyridines has been developed through copper-catalyzed oxidative decarboxylative coupling of C(sp3) aryl acetic acids with oxime acetates in DMF at 150° under an oxygen atm. Various functional groups were well tolerated and provided the corresponding 2,4,6-tri-Ph pyridines in good to excellent yields.

New Journal of Chemistry published new progress about Carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Safety of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Gang published the artcileCatalytic enantioselective oxidative coupling of saturated ethers with carboxylic acid derivatives, Synthetic Route of 104-01-8, the main research area is ether azolidinyl alkanone preparation regioselective enantioselective cross dehydrogenative coupling.

A formal catalytic enantioselective cross-dehydrogenative coupling of saturated ethers with diverse carboxylic acid derivatives involving an initial oxidative acetal formation, followed by nickel(II)-catalyzed asym. alkylation. The one-pot, general and modular method exhibited wide compatibility of a broad range of saturated ethers not only including prevalent THF and tetrahydropyran but also including medium- and large-sized cyclic moieties and acyclic ones with excellent enantioselectivity and functional group tolerance. The application in the rapid preparation of biol. active mols. that are difficult to access with existing methods was also demonstrated.

Nature Communications published new progress about Aliphatic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem