Category: 104-01-8

Nguyen, Khang X. published the artcileSulfur-Mediated Decarboxylative Coupling of 2-Nitrobenzyl Alcohols and Arylacetic Acids, Safety of 4-Methoxyphenylacetic acid, the main research area is nitro benzylalc arylacetic acid sulfur mediated decarboxylative coupling; aryl quinazoline.

A new method for the synthesis of substituted quinazolines by the condensation of 2-nitrobenzyl alcs. with arylacetic acids. The transformation requires the use of urea as a nitrogen source, elemental sulfur as a promoter, DABCO as a base and DMSO as a solvent. Functionalities such as chloro, fluoro, trifluoromethyl, thienyl and indolyl groups were all compatible with the reaction conditions. Because this method uses stable simple substrates to obtain the N,N-heterocycles in the absence of transition metals, it offers a potential pathway for preparing complex structures under mild conditions.

Synlett published new progress about Aliphatic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Safety of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhong, Jun-Song published the artcileDesulfonylative Electrocarboxylation with Carbon Dioxide, HPLC of Formula: 104-01-8, the main research area is aralkyl carboxylic acid preparation; benzyl sulfone carbon dioxide desulfonylative electrocarboxylation.

Electrocarboxylation of organic halides is one of the most investigated electrochem. approaches for converting thermodynamically inert carbon dioxide (CO2) into value-added carboxylic acids. By converting organic halides into their sulfone derivatives ArC(R)(R1)S(O)2C6H5 [Ar = Ph, thiophen-3-yl, 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzen-1-yl, etc.; R = H, Me, Ph, D, but-2-yn-1-yl, etc.; R1 = H, Me, D, 2-methylprop-2-en-1-yl, etc.; RR1 = -(CH2)5-, -CH2CH=CHCH2-], a highly efficient electrochem. desulfonylative carboxylation protocol have been developed. Such a strategy takes advantage of CO2 as the abundant C1 building block for the facile preparation of multifunctionalized carboxylic acids ArC(R)(R1)C(O)OH, including the nonsteroidal anti-inflammatory drug ibuprofen, under mild reaction conditions.

Journal of Organic Chemistry published new progress about Aralkyl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, HPLC of Formula: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Guo, Jing published the artcileAn efficient approach to access 1,1,2-triarylethanes enabled by the organo-photoredox-catalyzed decarboxylative addition reaction, Application In Synthesis of 104-01-8, the main research area is triarylethane diarylethylamine preparation green chem; carboxylic acid para quinone methide decarboxylative conjugate addition; photoredox organocatalyst.

An efficient protocol for the synthesis of 1,1,2-triarylethanes I (R1 is 4-OH-3,5-(t-Bu)2 and 4-OH-3,5-(i-Pr)2; R2 is H, 2-OMe, 4-CN, etc.; R3 is 2-Me, 3,4-(OMe)2, 4-Br, etc.) and 2,2-diarylethylamines II (R4 is NH(Boc); R5 is H, i-Pr, Bn, etc; R4R5 is (CH2)2N(Boc)(CH2)2 and (CH2)2O(CH2)2) with biol. and pharmacol. potential via organo-photoredox-catalyzed decarboxylative 1,6-conjugate addition of carboxylic acids to para-quinone methides has been developed. Different from the traditional transition-metal catalyzed multi-step synthetic strategy, this process involves a photoredox-promoted free radical pathway. A variety of structurally diverse products can be easily obtained under metal-free conditions in good to excellent yields (38 examples, up to 98% yield) in one step.

Organic Chemistry Frontiers published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mancinelli, Joseph P. published the artcileTris(pentafluorophenyl)borane-Catalyzed Cyclopropanation of Styrenes with Aryldiazoacetates, Application of 4-Methoxyphenylacetic acid, the main research area is phenyldiazoacetate aryl alkene preparation pentafluorophenyl borane catalyst diastereoselective cyclopropanation; aryl phenylcyclopropane carboxylate preparation.

The strong sterically encumbered Lewis acid tris(pentafluorophenyl)borane as a catalyst for the cyclopropanation of unactivated alkenes using aryldiazoacetates was reported. The cyclopropane products were synthesized using 10 mol % of the catalyst under mild conditions in up to 90% yield (8:1 to >20:1 dr). The reaction proceeded via a Lewis acid-activated carbene.

ACS Catalysis published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

To, Tuong A. published the artcileA new pathway to pyrrolo[1,2-a]quinoxalines via solvent-free one-pot strategy utilizing FeMoSe nanosheets as efficient recyclable synergistic catalyst, SDS of cas: 104-01-8, the main research area is pyrroloquinoxaline preparation; nitroaniline aryl acetic acid dimethoxy THF tandem FeMoSe catalyst.

FeMoSe nanocatalyst was synthesized using solvothermal approach from readily available precursors, namely Mo(CO)6, FeSO4 and Se, and characterized by spectroscopic and microscopic anal. The FeMoSe material offered high catalytic activity in the synthesis of pyrrolo[1,2-a]quinoxalines I [R = H, Me, OMe, etc.; Ar = Ph, 2-thiophenyl, 4-BrC6H4, etc.] via solvent-free one-pot strategy starting from 2-nitroanilines. The FeMoSe material offered high catalytic activity in the synthesis of pyrrolo[1,2-a]quinoxalines I via solvent-free one-pot strategy starting from 2-nitroanilines. The synthesis of pyrrolo[1,2-a]quinoxalines I using such a synergistic bimetallic system was not previously reported.

Journal of Catalysis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (nitro). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hussain, Farhaz Liaquat published the artcileA mild aerobic oxidation of benzyl alcohols and oxidative decarboxylation of phenylacetic acids by cellulose-supported Ag-Ag2S nanoparticles, Name: 4-Methoxyphenylacetic acid, the main research area is aldehyde preparation green chem; benzyl alc aerobic oxidation phenylacetic acid oxidative decarboxylation; cellulose supported silver sulfide nanoparticle preparation catalyst.

Synthesis, characterization and catalytic activity of Ag-Ag2S nanoparticles supported on environmentally benign cellulose matrix has been discussed. The nanoparticles carry out controlled oxidation of benzylic alcs. to aldehydes at room temperature Same nanoparticles also carry out oxidative decarboxylation of phenylacetic acid and decarboxylation of mandelic acid derivatives to corresponding aldehydes under comparatively milder conditions. Stability and recyclability of the catalyst has been studied. The advantages of the catalyst developed in this work over other previous reports include room temperature or comparatively low temperature reaction, shorter reaction times, no requirement of stoichiometric oxidant or ligands, use of green solvents, functional group tolerance, and recyclability.

Catalysis Communications published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Do, Nhan T. published the artcileFunctionalization of activated methylene C-H bonds with nitroarenes and sulfur for the synthesis of thioamides, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is nitroarene aryacetic acid sulfur DABCO three component coupling reaction; benzyl alc nitroarene sulfur DABCO three component coupling reaction; aryl benzothioamide preparation green chem.

A method to obtain arylthioamides by the functionalization of sp3 C-H bonds in arylacetic acids and benzyl alcs. was reported. Reactions proceeded without the use of any solvents and were compatible with many functionalities and heterocycles. These conditions allowed for a rapid synthesis of thioamides from simple, com. substrates.

Organic & Biomolecular Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ran, Chuan-Kun published the artcileVisible-Light Photoredox-Catalyzed Carboxylation of Activated C(sp3)-O Bonds with CO2, Related Products of isoquinoline, the main research area is carboxylic acid preparation green chem; benzyl alc carbon dioxide photochem carboxylation tetrakis diphenylaminoisophthalonitrile catalyst; benzylic carbonate carbon dioxide photochem carboxylation tris diphenylaminodifluorobenzonitrile catalyst.

A visible-light photoredox-catalyzed carboxylation of activated C(sp3)-O bonds with CO2 under mild and transition-metal-free conditions was reported. A variety of benzyl alcs. and derivatives, RCH(R1)OR2 (R = 4-phenylphenyl, 6-methoxynaphthalen-2-yl, 1-benzofuran-2-yl, etc.; R1 = H, Me, cyclohexyl, propan-2-yl, etc.; R2 = H, Piv, Ac) bearing primary, secondary, and more challenging tertiary C(sp3)-O bonds, undergo carboxylation with CO2, generating valuable aryl acetic acids RCH(R1)COOH, such as ibuprofen, naproxen, fenoprofen, and flurbiprofen, with broad substrate scope and good functional group tolerance. Moreover, this strategy is also applicable to other carboxylates of α-hydroxyl amides, esters, and nitriles, as well as allyl alcs., representing a practical method for aliphatic carboxylic acid synthesis.

ACS Catalysis published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wakuluk-Machado, Anne-Marie published the artcilePd(OH)2/C, a Practical and Efficient Catalyst for the Carboxylation of Benzylic Bromides with Carbon Monoxide, Application of 4-Methoxyphenylacetic acid, the main research area is benzylic bromide carbon monoxide palladium carboxylation catalyst; arylacetic acid preparation.

A simple, efficient, cheap, and broadly applicable system for the carboxylation of benzylic bromides with carbon monoxide and water is reported. Upon simple reaction with only 2.5 wt % of Pearlman’s catalyst and 10 mol % of tetrabutylammonium bromide in THF at 110°C for 4 h, a range of benzylic bromides can be smoothly converted to the corresponding arylacetic acids in good to excellent yields after simple extraction and acid-base wash. The reaction was found to be broadly applicable, scalable, and could be successfully extended to the use of ex situ-generated carbon monoxide and applied to the synthesis of the nonsteroidal anti-inflammatory drug diclofenac.

Organic Process Research & Development published new progress about Aralkyl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hu, Sha published the artcileTfOH-Catalyzed Cascade C-H Activation/Lactonization of Phenols with α-Aryl-α-diazoesters: Rapid Access to α-Aryl Benzofuranones, Name: 4-Methoxyphenylacetic acid, the main research area is arylbenzofuranone synthesis triflic acid catalyzed cascade phenol aryldiazoacetate.

Aryl benzofuranones are privileged structural units present in natural products and pharmaceutically relevant compounds with high bioactivity and therapeutic value; synthetic access to these scaffolds remains an area of intensive interest. A new and efficient TfOH-catalyzed cascade ortho C-H activation/lactonization of phenols with α-aryl-α-diazoacetates is reported. This metal-free protocol provides an operationally simple and rapid method for the one-pot assembly of diverse α-aryl benzofuranones in high yields with broad substrate scope, a readily starting material, good chemo-regioselectivity, and excellent functional group compatibility.

Journal of Organic Chemistry published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem