Guo, Jing published the artcileAn efficient approach to access 1,1,2-triarylethanes enabled by the organo-photoredox-catalyzed decarboxylative addition reaction, Application In Synthesis of 104-01-8, the main research area is triarylethane diarylethylamine preparation green chem; carboxylic acid para quinone methide decarboxylative conjugate addition; photoredox organocatalyst.
An efficient protocol for the synthesis of 1,1,2-triarylethanes I (R1 is 4-OH-3,5-(t-Bu)2 and 4-OH-3,5-(i-Pr)2; R2 is H, 2-OMe, 4-CN, etc.; R3 is 2-Me, 3,4-(OMe)2, 4-Br, etc.) and 2,2-diarylethylamines II (R4 is NH(Boc); R5 is H, i-Pr, Bn, etc; R4R5 is (CH2)2N(Boc)(CH2)2 and (CH2)2O(CH2)2) with biol. and pharmacol. potential via organo-photoredox-catalyzed decarboxylative 1,6-conjugate addition of carboxylic acids to para-quinone methides has been developed. Different from the traditional transition-metal catalyzed multi-step synthetic strategy, this process involves a photoredox-promoted free radical pathway. A variety of structurally diverse products can be easily obtained under metal-free conditions in good to excellent yields (38 examples, up to 98% yield) in one step.
Organic Chemistry Frontiers published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem