Category: 104-01-8

Barysevich, Maryia V. published the artcilePalladium-Catalyzed 2-(Neopentylsulfinyl)aniline Directed C-H Acetoxylation and Alkenylation of Arylacetamides, Formula: C9H10O3, the main research area is aryl acetamide regioselective acetoxylation diacetoxyiodobenzene palladium catalyst; acetoxy arylacetamide preparation; cyclopropanol stereoselective regioselective alkenylation arylacetamide palladium catalyst; alkenyl arylacetamide preparation.

The 2-(neopentylsulfinyl)aniline directing group that promotes rapid palladium-catalyzed C-H acetoxylation and alkenylation of arylacetamides has been developed. The acetoxylation reached completion within only 40 min at 100°C and led to the bis-functionalized products. Alternatively, the reaction can be carried out at room temperature, which is beneficial for sensitive substrates. For the alkenylation, a protocol has been developed where easily available 1-substituted cyclopropanols were employed as equivalent of vinyl ketones.

European Journal of Organic Chemistry published new progress about Acetates Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Doan, Son H. published the artcileA New Synthetic Pathway to Triphenylpyridines via Cascade Reactions Utilizing a New Iron-Organic Framework as a Recyclable Heterogeneous Catalyst, SDS of cas: 104-01-8, the main research area is benzenetricarboxylic acid biphenyldicarboxylic iron complex preparation thermal stability crystallinity; phenylacetic acid acetophenone ammonium acetate iron tandem aldol cyclocondensation; triphenyl pyridine preparation.

A new iron-organic framework, VNU-22 ̅{[Fe3(BTC)(BPDC)2].11.97H2O}, constructed from BTC3-, BPDC2-pillars and infinite [Fe3(CO2)7]∞rod SBU, was obtained. The VNU-22 was utilized as a heterogeneous catalyst in the synthesis of 2,4,6-triphenylpyridines via cascade reactions from acetophenones and phenylacetic acids with ammonium acetate as a nitrogen source. The VNU-22 was more active in the cascade reactions than many homogeneous and heterogeneous catalysts. The framework catalyst was recovered and reutilized without an appreciable decline in its performance. To our best knowledge, this synthetic pathway to 2,4,6-triphenylpyridines was not previously reported and would attract interests from the chem. industry.

European Journal of Organic Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tank, Manishkumar J. published the artcileSynthesis and biological activities of Chalcone and Pyrimidine derivatives of imidazothiadiazole moiety, Application In Synthesis of 104-01-8, the main research area is imidazothiadiazolyl phenylpropenyl chromenone preparation antibacterial antifungal antitubercular antimalarial activity; pyrimidinyl imidazothiadiazolyl chromenone preparation antibacterial antifungal antitubercular antimalarial activity.

Target mols. based on imidazothiazole-chalcone derivatives I (R1 = H, OH, NO2, MeO; R2 = H, OH, NO2, MeO, Br, Cl, Me) and imidazothiazole-pyrimidine derivatives II were synthesized. Chalcone series of compounds I was synthesized by reaction between 2-(4-methoxybenzyl)-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde and various substituted acetophenones 4-R2-3-R1C6H3C(O)Me and these chalcones I were converted into pyrimidine series II. These derivatives of chalcones and pyrimidine were examined in vitro for antimicrobial and antifungal activities against clin. isolated strains and their characterization was confirmed by FTIR, 1H-NMR, 13C and LCMS.

Chemistry & Biology Interface published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shirase, Satoru published the artcileCerium(IV) Carboxylate Photocatalyst for Catalytic Radical Formation from Carboxylic Acids: Decarboxylative Oxygenation of Aliphatic Carboxylic Acids and Lactonization of Aromatic Carboxylic Acids, Name: 4-Methoxyphenylacetic acid, the main research area is aldehyde alc preparation; carboxylic acid decarboxylative oxygenation cerium carboxylate photocatalyst.

We found that in situ generated cerium(IV) carboxylate generated by mixing the precursor Ce(OtBu)4 with the corresponding carboxylic acids served as efficient photocatalysts for the direct formation of carboxyl radicals from carboxylic acids under blue light-emitting diodes (blue LEDs) irradiation and air, resulting in catalytic decarboxylative oxygenation of aliphatic carboxylic acids to give C-O bond-forming products such as aldehydes and ketones. Control experiments revealed that hexanuclear Ce(IV) carboxylate clusters initially formed in the reaction mixture and the ligand-to-metal charge transfer nature of the Ce(IV) carboxylate clusters was responsible for the high catalytic performance to transform the carboxylate ligands to the carboxyl radical. In addition, the Ce(IV) carboxylate cluster catalyzed direct lactonization of 2-isopropylbenzoic acid to produce the corresponding peroxy lactone and γ-lactone via intramol. 1,5-hydrogen atom transfer (1,5-HAT).

Journal of the American Chemical Society published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Abhilash, Vishwanathan published the artcileChemoselective hydrosilylation of carboxylic acids using a phosphine-free ruthenium complex and phenylsilane, COA of Formula: C9H10O3, the main research area is alc preparation chemoselective; carboxylic acid phenylsilane agent hydrosilylation tandem ruthenium complex catalyst.

A highly chemoselective hydrosilylation of carboxylic acids RC(O)OH [R = 4-methoxyphenylmethyl, benzo[1,3]dioxol-5-yl, benzofuran-6-yl, etc.] was achieved using a bench-stable, phosphine-free Ru-complex tethered with hemi-labile thiophene ligands as the catalyst, employing phenylsilane as the reducing agent. The methodol. was further elaborated towards the one-pot synthesis of 1H-indole and 3,4-dihydro-2H-benzo[1,4]oxazine via tandem reduction/cyclization of acid and nitro group.

Journal of Organometallic Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jing, Ke published the artcileVisible-light photoredox-catalyzed carboxylation of benzyl halides with CO2: Mild and transition-metal-free, COA of Formula: C9H10O3, the main research area is aryl acetic acid preparation visible light; benzyl chloride bromide carbon dioxide carboxylation photoredox catalyst.

The visible-light photoredox-catalyzed carboxylation of benzyl chlorides and bromides with CO2 has been reported. With inexpensive organic dyes as photocatalysts and amines as electron donors, this carboxylation proceeds well in the absence of sensitive organometallic reagents, transition metal catalysts, or metallic reductants. A wide range of com. available and inexpensive benzyl halides undergo such carboxylation to give valuable aryl acetic acids, including several pharmaceutical mols. and drug precursors, in moderate to high yields. Moreover, this reaction features mild reaction conditions (one atm. pressure of CO2 and room temperature), broad substrate scope, good functional group tolerance, easy scalability, and low catalyst loading, thus providing an efficient approach for the assembly of aryl acetic acids.

Chinese Journal of Catalysis published new progress about Benzyl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bazyar, Zahra published the artcileOn/Off O2 Switchable Photocatalytic Oxidative and Protodecarboxylation of Carboxylic Acids, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is photocatalytic oxidative protodecarboxylation carboxylic acid.

Photoredox catalysis in recent years has manifested a powerful branch of science in organic synthesis. Although merging photoredox and metal catalysts has been a widely used method, switchable heterogeneous photoredox catalysis has rarely been considered. Herein, we open a new window to use a switchable heterogeneous photoredox catalyst which could be turned on/off by changing a simple stimulus (O2) for two opponent reactions, namely, oxidative and protodecarboxylation. Using this strategy, we demonstrate that Au@ZnO core-shell nanoparticles could be used as a switchable photocatalyst which has good catalytic activity to absorb visible light due to the localized surface plasmon resonance effect of gold, can decarboxylate a wide range of aromatic and aliphatic carboxylic acids, have multiple reusability, and are a reasonable candidate for synthesizing both aldehydes/ketones and alkane/arenes in a large-scale set up. Some biol. active mols. are also shown via examples of the direct oxidative and protodecarboxylation which widely provided pharmaceutical agents.

Journal of Organic Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Campano, Teresa E. published the artcileEnantioselective Addition of Alkynyl Ketones to Nitroolefins Assisted by Bronsted Base/H-Bonding Catalysis, Application of 4-Methoxyphenylacetic acid, the main research area is nitro alkynone preparation diastereoselective enantioselective; alkynyl ketone nitroolefin conjugate addition bifunctional bronsted base catalyst; Brønsted bases; Michael reaction; alkynyl ketones; asymmetric catalysis; organocatalysis.

Various sets of enolizable alkynyl ketones (including Me ynones with α-aryl, α-alkenyl and α-alkoxy groups) were able to react smoothly with nitroolefins with the assistance of bifunctional Bronsted base/H-bond catalysts to provide nitro alkynones with two consecutive tertiary stereocenters I [R1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.; R2 = n-Pr, Ph, 2-furyl, etc.; R3 = MeC=CH2, HC=CHPh, Ph, OBn, etc.] in a highly diastereo- and enantioselective fashion. Further transformation of the obtained adducts into optically active acyclic and polycyclic mols., including some with intricate carbon skeletons, was also demonstrated.

Chemistry – A European Journal published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chang, Meng-Yang published the artcileTrifluoroacetic Anhydride Mediated One-Pot Synthesis of 1-Aryl Isochroman-3-ones via the Carboxy-Pictet-Spengler Reaction, Quality Control of 104-01-8, the main research area is arylacetic acid arylaldehyde ketone trifluoroacetic anhydride Pictet Spengler annulation; aryl isochromanone green one pot preparation.

In this paper, a novel and open-vessel route for the facile-operational synthesis of 1-aryl isochroman-3-ones is described via (CF3CO)2O (trifluoroacetic anhydride, TFAA)-mediated intermol. (4 + 2) annulation of oxygenated arylacetic acids with arylaldehydes or ketones under mild reaction conditions. A plausible mechanism is proposed and discussed herein. Various reaction conditions are investigated for efficient transformation under an environmentally friendly one-pot carboxy-Pictet-Spengler reaction.

Journal of Organic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Quality Control of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shen, Jia-Huan published the artcileSynergistic Copper and Chiral Lewis Base Catalysis for the Asymmetric Synthesis of Pyrrolo[1,2-a]indoles, Formula: C9H10O3, the main research area is synergism copper Lewis base catalyst decarboxylative cycloaddition; pyrroloindole enantioselective diastereoselective preparation; ethynyl indoloxazolidone carboxylic acid decarboxylative cycloaddition copper Lewis base.

The first asym. decarboxylative [3+2]-cycloaddition of ethynyl indoloxazolidones I (R1 = H, 6-Cl, 7-MeO, 9-Me, etc.) with carboxylic acids R2CH2CO2H (R2 = Ph, 4-FC6H4, 3-thienyl, 2-naphthyl, etc.) has been developed under synergistic catalysis of copper and chiral Lewis base. This protocol provides a direct and modular approach to biol. important pyrrolo[1,2-a]indoles II bearing two vicinal stereogenic centers with excellent diastereo- and enantioselectivities (up to >20:1 dr and >99% ee). In addition, utility of this methodol. was demonstrated by a scaled-up reaction and several synthetic transformations of the cycloadduct.

Chinese Journal of Chemistry published new progress about [3+2] Cycloaddition reaction, stereoselective (decarboxylative). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem