Shen, Jia-Huan published the artcileSynergistic Copper and Chiral Lewis Base Catalysis for the Asymmetric Synthesis of Pyrrolo[1,2-a]indoles, Formula: C9H10O3, the main research area is synergism copper Lewis base catalyst decarboxylative cycloaddition; pyrroloindole enantioselective diastereoselective preparation; ethynyl indoloxazolidone carboxylic acid decarboxylative cycloaddition copper Lewis base.
The first asym. decarboxylative [3+2]-cycloaddition of ethynyl indoloxazolidones I (R1 = H, 6-Cl, 7-MeO, 9-Me, etc.) with carboxylic acids R2CH2CO2H (R2 = Ph, 4-FC6H4, 3-thienyl, 2-naphthyl, etc.) has been developed under synergistic catalysis of copper and chiral Lewis base. This protocol provides a direct and modular approach to biol. important pyrrolo[1,2-a]indoles II bearing two vicinal stereogenic centers with excellent diastereo- and enantioselectivities (up to >20:1 dr and >99% ee). In addition, utility of this methodol. was demonstrated by a scaled-up reaction and several synthetic transformations of the cycloadduct.
Chinese Journal of Chemistry published new progress about [3+2] Cycloaddition reaction, stereoselective (decarboxylative). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem