Category: 104-01-8

Nguyen, Thanh Binh published the artcileSulfur-Promoted Decarboxylative Sulfurative Hexamerization of Phenylacetic Acids: Direct Approach to Hexabenzylidyne Tetrasulfides, Product Details of C9H10O3, the main research area is sulfur promoted decarboxylative sulfurative hexamerization phenylacetic acid; preparation hexabenzylidyne tetrasulfide.

During our experiments aimed at understanding the reaction pathways by which arylacetic acids were oxidatively decarboxylated and condensed with different nucleophiles in the presence of elemental sulfur, these acids have been treated with sulfur powder in DMSO (DMSO) and N-methylpiperidine in the absence of nucleophiles, producing a remarkable sym. sulfurated hexamer consisting of six benzylidyne moieties and four sulfur atoms.

Organic Letters published new progress about Condensation reaction (decarboxylative sulfurative hexamerization). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Product Details of C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Mao-Lin published the artcileHighly enantioselective carbene insertion into N-H bonds of aliphatic amines, HPLC of Formula: 104-01-8, the main research area is diazo ester amine aliphatic copper aminothiourea chiral carbene insertion; amino acid ester stereoselective preparation.

Aliphatic amines strongly coordinate, and therefore easily inhibit, the activity of transition-metal catalysts, posing a marked challenge to nitrogen-hydrogen (N-H) insertion reactions. We report highly enantioselective carbene insertion into N-H bonds of aliphatic amines using two catalysts in tandem: an achiral copper complex and chiral amino-thiourea. Coordination by a homoscorpionate ligand protects the copper center that activates the carbene precursor. The chiral amino-thiourea catalyst then promotes enantioselective proton transfer to generate the stereocenter of the insertion product. This reaction couples a wide variety of diazo esters and amines to produce chiral a-alkyl a-amino acid derivatives

Science (Washington, DC, United States) published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, HPLC of Formula: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pearson, Colin M. published the artcileA Regio- and Stereodivergent Synthesis of Homoallylic Amines by a One-Pot Cooperative-Catalysis-Based Allylic Alkylation/Hofmann Rearrangement Strategy, Category: isoquinoline, the main research area is perfluorophenyl alkanoate allyl electrophile alkanol tandem alkylation Hofmann rearrangement; methyl alkenyl carbamate diastereoselective enantioselective regioselective preparation; alkylation; amines; ammonium enolates; palladium; rearrangement.

A modular synthetic route to linear and branched homoallylic amines that operates through a sequential one-pot Lewis base/transition-metal catalyzed allylic alkylation/Hofmann rearrangement strategy. This protocol was operationally trivial, proceeded from simple and easily prepared substrates and catalysts and enabled all aspects of regio- and stereoselectivity to be controlled through a conserved exptl. protocol. Overall, the high levels of enantio-, regio- and diastereoselectivity obtained, in concert with the ability to access orthogonally protected or free amines, render this a straightforward and effective approach for the preparation of useful enantioenriched homoallylic amines. The utility of the products in the context of pharmaceutical synthesis were also demonstrated.

Angewandte Chemie, International Edition published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Chuangchuang published the artcileBF3·OEt2-promoted tandem Meinwald rearrangement and nucleophilic substitution of oxiranecarbonitriles, Synthetic Route of 104-01-8, the main research area is cyano aryloxirane nucleophile acid tandem Meinwald rearrangement nucleophilic substitution; benzeneacetamide preparation regioselective microwave irradiation green chem; aryl acetic acid preparation regioselective microwave irradiation green chem; phenylacetate preparation regioselective microwave irradiation green chem.

Tandem Meinwald rearrangement and nucleophilic substitution of oxiranenitriles was realized. Arylacetic acid derivatives were readily synthesized from 3-aryloxirane-2-carbonitriles with amines, alcs., or water in the presence of boron trifluoride under microwave irradiation, and the designed synthetic strategy includes introducing a cyano leaving group into arylepoxides and capturing the in-situ generated toxic cyanide with boron trifluoride, making the reaction efficient, safe and environmentally benign. The reaction occurred through an acid-promoted Meinwald rearrangement, producing arylacetyl cyanides, followed by an addition-elimination process with nitrogen or oxygen-containing nucleophilic amines, alcs. or water. The current method provided a new application of the tandem Meinwald rearrangement.

Organic & Biomolecular Chemistry published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Dabholkar, Vijay V. published the artcileSynthesis and biological evaluation of novel isoindoline 1,3-dione derivatives, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is benzyl thiadiazolyl isoindoline dione preparation antibacterial antifungal.

A new series of 2-(5-(substituted-benzyl)-1,3,4-thiadiazol-2-yl)-substituted-isoindoline-1,3-dione I [R = H, 2-Me, 4-Cl, 4-OMe, 2,4-di-Cl; R1 = H, 4-Me, 3-NO2] was synthesized by the reaction of 2-amino-5-(substituted)-benzyl-1,3,4-thiadiazole with substituted phthalic anhydride under solvent free conditions and the structures of the compounds were confirmed by IR and NMR. Representative compounds were screened for their anti-microbial activity against Gram-neg. bacteria, E. coli and P. aeruginosa and Gram-pos. bacteria, S. aureus, and C. diphtheriae using disk diffusion method. Some of these compounds were found to exhibit excellent antibacterial activity.

Heterocyclic Letters published new progress about Anhydrides, cyclic Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Yukang published the artcileElectrophotochemical Decarboxylative Azidation of Aliphatic Carboxylic Acids, HPLC of Formula: 104-01-8, the main research area is alkyl azide preparation green chem electrophotochem; aliphatic carboxylic acid decarboxylative azidation.

An electrophotochem. metal-catalyzed strategy that harnesses the power of light and electricity for radical decarboxylative functionalization of aliphatic carboxylic acids has been reported. This environmentally friendly protocol smoothly converts a diverse array of aliphatic carboxylic acids into the corresponding alkyl azides without using chem. oxidants or azido-group transfer reagents. The visible light energy and elec. energy can be applied in a spatially separated fashion with a modular electro-flow-cell for large-scale synthesis.

ACS Catalysis published new progress about Alkyl azides Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, HPLC of Formula: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Guan, Renpeng published the artcileDecarboxylative oxygenation of carboxylic acids with O2via a non-heme manganese catalyst, Category: isoquinoline, the main research area is manganese photocatalyst preparation; aryl carboxylic acid manganese photocatalyst oxygenation; arylaldehyde preparation; arylketone preparation.

Decarboxylative oxygenation of carboxylic acids using a non-heme manganese catalyst under blue light irradiation with O2 as the sole oxidant. Featuring mild reaction conditions, the protocol allowed readily available carboxylic acids to be converted into a wide variety of valuable aldehydes, ketones and amides. Mechanistic studies indicated that the decarboxylation and oxygenation involved the formation of active Mn-oxygen species.

Green Chemistry published new progress about Aromatic amides Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yadykov, Anton V. published the artcileCyclization of Polarized Divinyl Ketones under Aqueous and Ambient Conditions, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is combretastatin A4 analog preparation Nazarov cyclization polarized divinyl ketone.

An ‘on-water’ protocol has been developed for the synthesis of combretastatin A-4 (CA-4) analogs by cyclization of polarized triaryldivinyl ketones using hydrochloric acid as a promoter in 45-95% yields. The reaction time was reduced by about 30 times due to ultrasonic irradiation at ambient temperature The other advantages of this new method are operational simplicity, easy workup, no column purification, and applicability on a gram-scale. It was shown that the amphiphilicity of the substrate and a low energy barrier of the reaction are a prerequisite for electrophilic and concerted reactions under aqueous and ambient conditions.

Advanced Synthesis & Catalysis published new progress about Combretastatins Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Gangadurai, Chinnakuzhanthai published the artcileFeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: preparation of selected API impurities, Application In Synthesis of 104-01-8, the main research area is aryl heteroaryl aldehyde ketone preparation green chem; oxidative decarboxylation aryl heteroaryl acetic acid iron catalyst; ketorolac impurity B preparation.

Herein, the FeCl3-catalyzed oxidative decarboxylation of aryl- and heteroaryl acetic acids to the corresponding carbonyl compounds has been reported. A variety of useful aldehydes and ketones were prepared in a simple one-pot transformation by employing an environmentally benign, low-cost, and readily available iron salt. The utility of this method has been demonstrated by preparing five valuable API impurities including a multi-gram-scale synthesis of ketorolac impurity B for the first time.

Organic & Biomolecular Chemistry published new progress about Aryl aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Nadeem, Qaisar published the artcileTo Sandwich Technetium: Highly Functionalized Bis-Arene Complexes [99mTc(η6-arene)2]+ Directly from Water and [99mTcO4]-, Computed Properties of 104-01-8, the main research area is technetium sandwich compound preparation; crystal structure bisarene rhenium sandwich compound; mol structure bisarene rhenium sandwich compound; rhenium oxide reaction aromatic compound aqueous solution; aromatic compound reaction technetium oxide aqueous solution; molecular imaging; rhenium; sandwich complexes; screening; technetium.

The labeling of (bio)mols. with metallic radionuclides such as 99mTc demands conjugated, multidentate chelators. However, this is not always necessary since Ph rings can directly serve as integrated, organometallic ligands. Bis-arene sandwich complexes are generally prepared by the Fischer-Hafner reaction. In extension of this, [99mTc(η6-C6R6)2]+-type complexes are directly accessible from H2O and [99mTcO4]-, even using arenes incompatible with Fischer-Hafner conditions. To unambiguously confirm the nature of these unprecedented 99mTc complexes, their Re homologous were prepared by substituting naphthalene ligands in [Re(η6-C10H8)2]+ with the corresponding Ph groups. The ease with which highly stable [99mTc(η6-C6R6)2]+ complexes are formed under standard labeling conditions enables a multitude of new potential imaging agents based on com. pharmaceuticals or lead structures.

Angewandte Chemie, International Edition published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem