Yadykov, Anton V. published the artcileCyclization of Polarized Divinyl Ketones under Aqueous and Ambient Conditions, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is combretastatin A4 analog preparation Nazarov cyclization polarized divinyl ketone.
An ‘on-water’ protocol has been developed for the synthesis of combretastatin A-4 (CA-4) analogs by cyclization of polarized triaryldivinyl ketones using hydrochloric acid as a promoter in 45-95% yields. The reaction time was reduced by about 30 times due to ultrasonic irradiation at ambient temperature The other advantages of this new method are operational simplicity, easy workup, no column purification, and applicability on a gram-scale. It was shown that the amphiphilicity of the substrate and a low energy barrier of the reaction are a prerequisite for electrophilic and concerted reactions under aqueous and ambient conditions.
Advanced Synthesis & Catalysis published new progress about Combretastatins Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem