Category: 58-74-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58-74-2,1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline,as a common compound, the synthetic route is as follows.

Using a method previously reported by Bremner et al. [40], the free base of papaverine (1b, 0.50 g,1.5 mmol) was dissolved in CHCl3 (10 mL) and treated portion wise with MCPBA (0.35 g, 2.4 mmol)over 5 min. After completion of the addition, the solution was stirred at room temperature for 19h. The colorless precipitate that formed was filtered and the filtrate was extracted with 5% NaOH(3 25 mL). The CHCl3-soluble material was dried down then recrystallized from acetone to yieldpure papaverine N-oxide (12, 310 mg, 58%)., 58-74-2

58-74-2 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline 4680, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Article; Egbewande, Folake A.; Coster, Mark J.; Jenkins, Ian D.; Davis, Rohan A.; Molecules; vol. 24; 21; (2019);,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

58-74-2, 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE IV 6,7-Dimethoxy-1-(alpha-morpholinomethyl)-veratrylisoquinoline dihydrochloride (P3313) A mixture of 8 g (0.024 mole) of papaverine, 0.93 g (0.031 mole) of paraformaldehyde, 2.62 g (0.030 mole) of morpholine, 2.5 ml of concentrated hydrochloric acid, and 100 ml of ethyl alcohol was stirred and heated at reflux for 8 hours. The reaction mixture was cooled at -5C for 24 hours. The cooled reaction mixture was filtered to remove 1.5 g of papaverine hydrochloride. The filtrate was evaporated to a thick residue. This was dissolved in 100 ml of water and the solution made basic by the addition of 10N sodium hydroxide solution. The basic mixture was extracted with three 100 ml portions of ether. The ether extracts were combined, dried over anhydrous magnesium sulfate and filtered. The product was precipitated from the ether solution by the addition of hydrogen chloride. The precipitated solid was collected on a filter and recrystallized twice from isopropyl alcohol to yield 4.0 g of product melting at 182-184C. The infrared spectrum was consistent with the assigned structure. Analysis – Calculated for C25 H32 Cl2 N2 O5: C, 58.70; H, 6.32; Cl, 13.86; N, 5.48. Found: C, 58.91; H, 6.30; Cl, 13.37; N, 5.34.

58-74-2, The synthetic route of 58-74-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Armour Pharmaceutical Company; US3966724; (1976); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

58-74-2, 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To an 8 mL dram vial was added iodobenzene diacetate (0.6 mmol, 1.5 equiv), arene (0.4 mmol,1 eq.), dichloroethane (2 mL), then 1 M hydrochloric acid (2 mL, 5 equiv). The solution wasallowed to stir (1000 rpm) at 50 C for the indicated amount of time. After which the solution waswashed with saturated sodium bicarbonate, followed by saturated sodium thiosulfate andconcentrated. The crude mixture was then purified by column chromatography.

58-74-2, The synthetic route of 58-74-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Fosu, Stacy C.; Hambira, Chido M.; Chen, Andrew D.; Fuchs, James R.; Nagib, David A.; Chem; vol. 5; 2; (2019); p. 417 – 428;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem