With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.58-74-2,1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline,as a common compound, the synthetic route is as follows.
Using a method previously reported by Bremner et al. [40], the free base of papaverine (1b, 0.50 g,1.5 mmol) was dissolved in CHCl3 (10 mL) and treated portion wise with MCPBA (0.35 g, 2.4 mmol)over 5 min. After completion of the addition, the solution was stirred at room temperature for 19h. The colorless precipitate that formed was filtered and the filtrate was extracted with 5% NaOH(3 25 mL). The CHCl3-soluble material was dried down then recrystallized from acetone to yieldpure papaverine N-oxide (12, 310 mg, 58%)., 58-74-2
58-74-2 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxyisoquinoline 4680, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Article; Egbewande, Folake A.; Coster, Mark J.; Jenkins, Ian D.; Davis, Rohan A.; Molecules; vol. 24; 21; (2019);,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem