Category: 5961-59-1

Jiang, Lei published the artcileN-Monomethylation of Amines with Methanol by Syndiotactic Poly(aminostyrene)-supported Palladium Nanoparticle Catalyst, Product Details of C8H11NO, the main research area is methyl amine preparation green chem; primary amine methanol monomethylation syndiotactic polyaminostyrene support palladium nanocatalyst.

Palladium nanocatalyst supported on dimethylamino-functionalized syndiotactic polystyrene (Pd@sPSNMe2) showed high activity and selectivity for the N-monomethylation of various primary amines RNH2 (R = Ph, cyclohexyl, 3-(morpholin-4-yl)propyl, 2-(1H-indol-3-yl)ethyl, etc.) using methanol as methylation reagent under air to prepare monomethylated amines RNH(CH3), 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole and N-methyl-1H-benzo[d]imidazole. The excellent catalytic performance could be associated with the ultrafine palladium nanoparticles and high amine-adsorbing capacity of the catalyst. The Pd@sPS-NMe2 catalyst was highly robust, and could be easily recovered by filtration and reused more than ten times without decrease in activity and selectivity.

Asian Journal of Organic Chemistry published new progress about Green chemistry. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Zhaofei published the artcileSemiconductor photocatalysis to engineering deuterated N-alkyl pharmaceuticals enabled by synergistic activation of water and alkanols, Formula: C8H11NO, the main research area is deuterated Nalkyl pharmaceutical green preparation; amine semiconductor photocatalysis water alkanol synergistic activation.

Herein rationally design photocatalytic water-splitting to furnished [H] or [D] and isotope alkanol-oxidation by photoexcited electron-hole pairs on a polymeric semiconductor was reported. The controlled installation of N-CH3, -CDH2, -CD2H, -CD3, and -13CH3 groups into pharmaceutical amines thus was demonstrated by tuning isotopic water and methanol. More than 50 examples with a wide range of functionalities were presented, demonstrating the universal applicability and mildness of this strategy. Gram-scale production was realized, paving the way for the practical photosynthesis of pharmaceuticals.

Nature Communications published new progress about Green chemistry. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Mingyue published the artcileFacile Synthesis of a Novel Heterogeneous Rh/COF Catalyst and Its Application in Tandem Selective Transfer Hydrogenation and Monomethylation of Nitro Compounds with Methanol, Safety of 4-Methoxy-N-methylaniline, the main research area is heterogeneous rhodium catalyst preparation; nitro compound methanol monomethylation.

The development of transition-metal heterogeneous catalysts for economical and effective synthesis of N-methylamine, especially for the monomethylation of amines, is still challenging. Herein, two Rh-supported covalent organic framework (COF) heterogeneous catalysts Rh/MelCOF were facile-synthesized by a Schiff base reaction using melamine as a precursor, and, for the first time, it was successfully applied to the effective and high selective tandem reaction of transfer hydrogenation and monomethylation of nitroarom. hydrocarbons, with methanol as a C1 and hydrogenation source. A series of nitroarom. hydrocarbons, including heterocyclic or sterically hindered derivatives, can be well tolerated, and the catalyst could also be reused four times without losing significant reactivity. At the same time, the study of the Rh/MelCOF mechanism supports the hydrogen-borrowing mechanism and puts forward the reaction pathway of azobenzene as an intermediate, which is better than the hydrogen-transfer pathway from N-phenylhydroxylamine to aniline directly. This work expands the application of COF catalysts and provides an effective way to obtain mono-N-methylated amines from nitroarom. hydrocarbons, as well as the detailed mechanism of Rh/COF-catalyzed tandem transfer hydrogenation and monomethylation of amines.

Industrial & Engineering Chemistry Research published new progress about Heterogeneous catalysts. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Genre, Caroline published the artcileAdditive-free selective methylation of secondary amines with formic acid over a Pd/In2O3 catalyst, Safety of 4-Methoxy-N-methylaniline, the main research area is methylamine preparation; secondary amine formic acid methylation palladium catalyst.

Formic acid is used as the sole carbon and hydrogen source in the methylation of aromatic and aliphatic amines R1NHR2 (R1 = Ph, Bn, cyclohexyl, propan-2-yl, etc.; R2 = H, Me, cyclohexyl, Ph, propan-2-yl; R1R2 = -CH2CH2OCH2CH2-) to methylamines R1N(CH3)R2. The reaction proceeds via a formylation/transfer hydrogenation pathway over a solid Pd/In2O3 catalyst without the need for any additive.

Catalysis Science & Technology published new progress about Methylation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Jinhui published the artcileUnveiling Extreme Photoreduction Potentials of Donor-Acceptor Cyanoarenes to Access Aryl Radicals from Aryl Chlorides, Formula: C8H11NO, the main research area is aryl chloride boronate light cyanoarene photoreductive borylation catalyst; arylboronate preparation; phosphine aryl chloride light cyanoarene phosphorylation catalyst; arylphosphonium salt preparation.

Since the seminal work of Zhang in 2016, donor-acceptor cyanoarene-based fluorophores, such as 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN), have been widely applied in photoredox catalysis and used as excellent metal-free alternatives to noble metal Ir- and Ru-based photocatalysts. However, all the reported photoredox reactions involving this chromophore family are based on harnessing the energy from a single visible light photon, with a limited range of redox potentials from -1.92 to +1.79 V vs SCE. Here, we document the unprecedented discovery that this family of fluorophores can undergo consecutive photoinduced electron transfer (ConPET) to achieve very high reduction potentials. One of the newly synthesized catalysts, 2,4,5-tri(9H-carbazol-9-yl)-6-(ethyl(phenyl)amino)isophthalonitrile (3CzEPAIPN), possesses a long-lived (12.95 ns) excited radical anion form, 3CzEPAIPN�*, which can be used to activate reductively recalcitrant aryl chlorides (Ered �-1.9 to -2.9 V vs SCE) under mild conditions. The resultant aryl radicals can be engaged in synthetically valuable aromatic C-B, C-P, and C-C bond formation to furnish arylboronates, arylphosphonium salts, arylphosphonates, and spirocyclic cyclohexadienes.

Journal of the American Chemical Society published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Murata, Takumi published the artcileDeoxygenative CO2 conversions with triphenylborane and phenylsilane in the presence of secondary amines or nitrogen-containing aromatics, Application of 4-Methoxy-N-methylaniline, the main research area is secondary amine indole deoxygenative methylation triphenylborane catalyst.

BPh3 catalyzed the N-methylation of secondary amines and the C-methylenation (methylene-bridge formation between aromatic rings) of N,N-dimethylanilines or 1-methylindoles in the presence of CO2 (1 atm) and PhSiH3 without solvent at 30-40 °C. A cascade reaction from 1-methyl-2-oxindole to 3,3â€?methylenebis(1-methylindole) via 1-methylindole also proceeded.

Green Chemistry published new progress about Methylation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Katayama, Shintaro published the artcileManganese(III)-Based Oxidative Cyclization of N -Aryl-2-oxocycloalkane-1-carboxamides: Synthesis of Spiroindolinones, SDS of cas: 5961-59-1, the main research area is aryl oxocycloalkane carboxamide oxidative cyclization; spiro cycloalkane indoline dione preparation.

The Mn(III)-based oxidative cyclization of twenty-five N-aryl-2-oxocycloalkane-1-carboxamides was investigated. The reactions progressed efficiently to give the desired spiro[cycloalkane-1,3′-indoline]-2,2′-diones in high to quant. yields. The easy conversion of the carbonyl functional group of one of the indoline products, 1′-methylspiro[cyclohexane-1,3′-indoline]-2,2′-dione, was also demonstrated.

Synthesis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, SDS of cas: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yuan, Jingwen published the artcilePIFA/TEMPO-Mediated Oxidative Cascade Cyclization of α-[(β-Amino)propenoyl]-Alkylamides: Access to Polysubstituted 3,7-Dihydrooxazolo[4,5-c]pyridine-2,4,6(5H)-triones, Formula: C8H11NO, the main research area is methylamino oxo phenylpentenamide PIFA TEMPO oxidative tandem heterocyclization; phenyl oxazolopyridinetrione regioselective chemoselective preparation green chem.

A novel oxidative cascade cyclization of α-[(β-amino)propenoyl]-alkylamides mediated by Ph iodine (III) bis(trifluoroacetate) (PIFA) and 2,2,6,6-tetra-Me piperidin-1-oxyl (TEMPO) was described. This unprecedented transformation features mild reaction conditions, simple execution, high chemo- and regio-selectivity and thereby provided a facile and efficient protocol for the synthesis of polysubstituted 3,7-dihydro-oxazolo[4,5-c]pyridine-2,4,6-(5 H)-triones.

Advanced Synthesis & Catalysis published new progress about Chemoselectivity. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Feng, Fang-Fang published the artcileTungsten-Catalyzed Transamidation of Tertiary Alkyl Amides, Product Details of C8H11NO, the main research area is tertiary alkyl amide transamidation tungsten catalyst.

Transamidation has recently emerged as a straightforward and convenient means to diversify amides. However, the kinetically and thermodynamically demanding transamidation of notoriously robust, fully alkyl-substituted tertiary amides still remains a longstanding challenge. Here, a method for the activation of tertiary alkyl amides to streamline transamidation using simple tungsten(VI) chloride as a catalyst and chlorotrimethylsilane as an additive is described. The highly electrophilic and oxophilic tungsten catalyst enables the selective scission of a C-N bond of tertiary alkyl amides to effect transamidation of a myriad of structurally and electronically diverse tertiary alkyl amides and amines. Mechanistic study implies that the synergistic effect of the catalyst and the additive could pronouncedly induce the nucleophilic acyl substitution of tertiary alkyl amide with amine to realize transamidation.

ACS Catalysis published new progress about Transamidation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ke, Zhengang published the artcileAlcohol promoted N-methylation of anilines with CO2/H2 over a cobalt catalyst under mild conditions, Application of 4-Methoxy-N-methylaniline, the main research area is amine methylation carbon dioxide hydrogen cobalt catalyst ethanol promoter.

Herein, an alc. (e.g., ethanol) promoted strategy for the N-methylation of anilines with CO2/H2 with high efficiency under mild conditions (e.g., 125°), which is achieved over a cobalt catalytic system composed of Co(OAc)2·4H2O, triphos and Sn(OTf)2 was presented. This catalytic system has a broad substrate scope and is tolerant toward a wide range of anilines and N-Me anilines, and a series of N,N-di-Me anilines were obtained in high yields. Mechanism investigation indicates that the alc. solvent shifts the equilibrium of CO2 hydrogenation by forming an alkyl formate, which further reacts with the amine to produce N-formamide, and Sn(OTf)2 promotes the deoxygenative hydrogenation of N-formamides to afford N-methylamines. This is the first example of the N-methylation of amines with CO2/H2 over a cobalt catalytic system, which shows comparable performance to the reported Ru catalysts and may have promising applications.

Green Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem