Category: 5961-59-1

Lu, Chunlei published the artcileDirect N-Alkylation/Fluoroalkylation of Amines Using Carboxylic Acids via Transition-Metal-Free Catalysis, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is amine carboxylic acid metal free fluoroalkylation; fluoroalkylamine preparation; carboxylic acid amine metal free alkylation; alkylamine preparation.

A scalable protocol of direct N-mono/di-alkyl/fluoroalkylation of primary/secondary amines was constructed with various carboxylic acids as coupling agents under the catalysis of a simple air-tolerant inorganic salt, K3PO4. Advantageous features include 100 examples, 10 drugs and drug-like amines, fluorinated complex tertiary amines, gram-scale synthesis and isotope-labeling amine, thus demonstrating the potential applicability in industry of this methodol. The involvement of relatively less reactive silicon-hydride compared with the traditional reactive metal-hydride or boron-hydride species required to reduce the amide intermediates presumably contributes to the remarkable functional group compatibility.

Advanced Synthesis & Catalysis published new progress about Alkylation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Das, Kanu published the artcileN-Alkylation of Amines Catalyzed by a Ruthenium-Pincer Complex in the Presence of in situ Generated Sodium Alkoxide, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is secondary amine preparation density functional theory; alc primary amine alkylation ruthenium catalyst.

The use of ruthenium-NNN-pincer complexes of the type (R2NNN)RuCl2(PPh3) (R = tBu, iPr, Cy and Ph) for the catalytic N-alkylation of primary amines R-NH2 (R = Ph, propan-2-yl, thiophen-2-ylmethyl, etc.) under solvent-free conditions were reported. For the first time, the base that is required to promote these reactions is generated in situ from the alcs. R1-OH (R1 = Bu, (4-fluorophenyl)methyl, furan-2-ylmethyl, etc.) by the use of sodium. The resulting sodium alkoxide regenerates the alcs. substrate while acting as the water scavenger thus mitigating the need of an addnl. base. Among the catalysts screened, (tBu2NNN)RuCl2(PPh3) (0.02 mol-%) gives very high turnovers and good yields at 140 °C. The (tBu2NNN)RuCl2(PPh3) catalyzed N-alkylation tolerates a variety of amine and alc. substrates. While excellent turnover (29000) was obtained for the (tBu2NNN)RuCl2(PPh3) (0.002 mol-%) catalyzed alkylation of aniline with cyclohexyl methanol, the turnovers obtained in the corresponding catalytic methylation of p-anisidine was also very high (12000). The (tBu2NNN)RuCl2(PPh3) catalyzed reactions have also been accomplished under open-vessel conditions resulting in a net dehydrogenative coupling reaction. This protocol has been used to transform benzene-1,2-diamine to benzimidazoles I (R2 = H, F, OMe) with high productivity (12000 turnovers). DFT studies indicate that while β-hydride elimination is rate-determining (RDTS: 24.31 kcal/mol) for the alc. dehydrogenation segment which is endothermic, insertion of the imine is rate-determining (RDTS: 11.26 kcal/mol) for its hydrogenation that is exothermic.

European Journal of Organic Chemistry published new progress about Alkylation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bouoidina, A. published the artcileAnisole derivatives as sustainable-green inhibitors for mild steel corrosion in 1 M HCl: DFT and molecular dynamic simulations approach, Related Products of isoquinoline, the main research area is anisole hydrochloric acid steel corrosion DFT mol dynamic simulation.

The search for new corrosion inhibitors, inexpensive and environmentally friendly as alternatives to various harmful synthetic compounds is one of the main challenges facing the chem. industry today. Hence, this work focused on the inhibition of corrosion of steel in 1 M HCl acid medium by three anisole derivatives, simples, economics, effectiveness, effectives and they have rarely been studied. The study of this series based on coupling theor. (DFT / Mol. Dynamic simulations) and electrochem. techniques revealed a very high inhibitory efficiency which exceeds 80% at an optimal concentration of 103 M for all inhibitors, with the compound P1 is the most effective. All these inhibitors obey the Langmuir isotherm and exhibit a mixed character by blocking, on the one hand, the reaction of the dissolution of anodic steel, and on the other hand, the reaction of cathodic reduction of hydrogen. Their adsorption takes place according to a charge transfer process by forming a protective film on the metal surface. A theor. calculation of the global and local quantum descriptors and mol. dynamic simulations has been undertaken to explain the mechanism of inhibition.

Journal of Molecular Liquids published new progress about Adsorption. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lin, Xiao-Tao published the artcileImmobilized Zn(OAc)2 on bipyridine-based periodic mesoporous organosilica for N-formylation of amines with CO2 and hydrosilanes, Computed Properties of 5961-59-1, the main research area is amide preparation; amine carbon dioxide phenylsilane formylation; zinc acetate bipyridine periodic mesoporous organosilica preparation catalyst.

Zinc acetate (Zn(OAc)2) was successfully immobilized on a bipyridine-based periodic mesoporous organosilica (BPy-PMO-TMS), as confirmed by solid-state NMR and energy-dispersive X-ray spectroscopies, X-ray diffractometry, and nitrogen adsorption/desorption isotherm analyses. The immobilized Zn complex, Zn(OAc)2(BPy-PMO-TMS), exhibited good catalytic activity during the N-formylations of amines and amides with CO2 and PhSiH3 to produce the corresponding formamides. Zn(OAc)2(BPy-PMO-TMS) with a lower Zn loading was found to exhibit higher catalytic activity.

New Journal of Chemistry published new progress about Adsorption. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lu, Chunlei published the artcileScalable direct N-methylation of drug-like amines using 12CO2/13CO2 by simple inorganic base catalysis, Safety of 4-Methoxy-N-methylaniline, the main research area is methyl amine preparation; amine carbon dioxide methylation tripotassium phosphate catalyst.

A general protocol for scalable direct N-methylation of wide-scope drug-like amines such as duloxetine, sertraline, tetrahydropapaverine, rasagiline, etc. using CO2 and polymethylhydrosiloxane-a nontoxic, aerobically-stable hydrosilane considered as an industrial waste-via simple inorganic base catalysis has been developed. A rare application of the Sabatier principle in organic chem. led to the discovery of cheap, nontoxic K3PO4 as an efficient catalyst. Preparations of a wide-scope drug-like amines with carbon-isotope label, e.g., I were also successfully achieved, enabling direct use of CO2 in studies of drug absorption, distribution, metabolism and excretion.

Science Bulletin published new progress about Methylation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mallo, Neil published the artcileHydrogen-Bonding Donor-Acceptor Stenhouse Adducts, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is donor acceptor Stenhouse adduct hydrogen bonding.

The binding of donor-acceptor Stenhouse adducts (DASAs) bearing hydrogen-bond recognition groups by Hamilton-type receptors significantly influenced their photoswitching properties by altering thermal barriers to isomerization. The thermal barrier between the most stable linear isomer and the photogenerated isomer is lowered on binding to a receptor, and this barrier is crucial for switching properties. The thermal isomerization was shown to proceed via a stepwise linear-enol-keto mechanism in DMSO where the tautomerization barrier is within 2 kJ · mol-1 of that of the rate-determining step, which may be important for analyzing switching properties.

ChemPhotoChem published new progress about Absorption. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lei, Lin-Sheng published the artcileThe synthesis of cyanoformamides via a CsF-promoted decyanation/oxidation cascade of 2-dialkylamino-malononitriles, Formula: C8H11NO, the main research area is cyanoformamide preparation; amino malononitrile cascade decyanation oxidation cesium fluoride promoted.

A mild and efficient method for the synthesis of cyanoformamides RR1NC(O)CN [R = R1 = Me, Et, n-Pr, n-Bu; R = Ph, 2-MeC6H4, Me, etc., R1 = Me, Et, n-Bu, Bn, etc.; RR1 = (CH2)5, (CH2)2O(CH2)2, (CH2)2CH(CH3)(CH2)2, etc.] was developed via CsF-promoted cascade decyanation/oxidation reactions of N,N-disubstituted amino-malononitriles. This method featured a wide substrate scope and high reaction efficiency and will facilitate the corresponding cyanoformamide-based biol. studies and synthetic methodol. development.

Organic & Biomolecular Chemistry published new progress about Decyanation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xin, Zhuo published the artcileRu-Catalyzed Switchable N-Hydroxyethylation and N-Acetonylation with Crude Glycerol, Category: isoquinoline, the main research area is beta amino alc regioselective preparation; amine polyol hydroxyethylation ruthenium catalyst; ketone beta amino regioselective preparation; polyol amine acetonylation ruthenium catalyst; acetonylation; hydrogen borrowing; hydroxyethylation; polyalcohol; switchable selectivity.

Highly efficient Ru-catalyzed selective C-C or C-O bond cleavage of polyols (e.g., crude glycerol) for N-hydroxyethylation or N-acetonylation of amines to give β-amino alcs. RR1N(CH2)2OH [R = Ph, 2-MeC6H4, 4-ClC6H4, etc.; R1 = Me, Et, Bn, etc.] and β-amino ketones ArNR2CH2C(O)Me [Ar = Ph, 2-MeC6H4, 4-BrC6H4, etc.; R2 = Me, Bn, etc.] in moderate-to-excellent yields was achieved through the hydrogen-borrowing approach. The use of new redox-active catalysts containing bisphosphine/thienylmethylamine ligands allowed this hydrogen-borrowing system to be operated selectively under both basic and acidic conditions.

ChemSusChem published new progress about Acetylation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Niansheng published the artcileHelical polycycle molecular semiconductor for durable and efficient perovskite solar cells, Application of 4-Methoxy-N-methylaniline, the main research area is polycycle mol semiconductor perovskite solar cell perovskite layer.

Despite the efficiency comparable to crystalline silicon photovoltaics, it is still a severe concern on the long-term stability under the stress of heat, light, and bias potential for perovskite solar cell (PSC). Here, we report a triple aza[6]helicene-based mol. semiconductor (TBTA[6]H) characteristic of a fully fused conjugated backbone. TBTA[6]H presents superior solubility and glass-transition temperature (Tg). An air-doped composite of TBTA[6]H with a high elec. conductivity of 353μS cm-1 is still featured by a Tg of 112°C, enabling the fabrication of 22% efficiency, 85°C durable PSCs. The TBTA[6]H composite not only exhibits an excellent morphol. stability at 85°C in PSCs, but also remarkably attenuates the thermal degradation of photoactive perovskite layer. The cell with TBTA[6]H also displays an excellent operation stability under the continuous full sunlight soaking at 55°C.

ACS Materials Letters published new progress about Doping (air). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wu, Xingxing published the artcileStereoselective synthesis of atropisomeric acridinium salts by the catalyst-controlled cyclization of ortho-quinone methide iminiums, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is atropisomeric acridinium salt stereoselective preparation intramol Friedel Crafts electrocyclization; Acridiniums; Atropisomers; Brønsted Acid Catalysis; Ion-Paring Catalysis; Ortho-Quinone Methide Iminiums.

Quinone methides are fundamental intermediates for a wide range of reactions in which catalyst stereocontrol is often achieved by hydrogen bonding. Herein, we describe the feasibility of an intramol. Friedel-Crafts 6π electrocyclization through ortho-quinone methide iminiums stereocontrolled by a contact ion pair. A disulfonimide catalyst activates racemic trichloroacetimidate substrates and imparts stereocontrol in the cyclization step, providing a new avenue for selective ortho-quinone methide iminium functionalization. A highly stereospecific oxidation readily transforms the enantioenriched acridanes into rotationally restricted acridiniums. Upon ion exchange, the method selectively affords atropisomeric acridinium tetrafluoroborate salts in high yields and an enantio-enrichment of up to 93 : 7 e.r. We envision that ion-pairing catalysis over ortho-quinone methide iminiums enables the selective synthesis of a diversity of heterocycles and aniline derivatives with distinct stereogenic units.

Angewandte Chemie, International Edition published new progress about Atropisomers. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem