Lu, Chunlei published the artcileScalable direct N-methylation of drug-like amines using 12CO2/13CO2 by simple inorganic base catalysis, Safety of 4-Methoxy-N-methylaniline, the main research area is methyl amine preparation; amine carbon dioxide methylation tripotassium phosphate catalyst.
A general protocol for scalable direct N-methylation of wide-scope drug-like amines such as duloxetine, sertraline, tetrahydropapaverine, rasagiline, etc. using CO2 and polymethylhydrosiloxane-a nontoxic, aerobically-stable hydrosilane considered as an industrial waste-via simple inorganic base catalysis has been developed. A rare application of the Sabatier principle in organic chem. led to the discovery of cheap, nontoxic K3PO4 as an efficient catalyst. Preparations of a wide-scope drug-like amines with carbon-isotope label, e.g., I were also successfully achieved, enabling direct use of CO2 in studies of drug absorption, distribution, metabolism and excretion.
Science Bulletin published new progress about Methylation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem